Encapsulated piscine (tilapia) islets for diabetes therapy: Studies in diabetic NOD and NOD-SCID mice

Xenotransplantation

Volumn 21, Issue 2, 2014, Pages 127-139

  Safley, Susan A ^a   Cui, Hong ^a   Cauffiel, Sean M D ^a   Xu, Bao You ^b   Wright, James R ^c   Weber, Collin J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Diabetic NOD mice; islets; microencapsulation; tilapia; xenotransplantation

Indexed keywords

ABATACEPT; ALGINIC ACID; BARIUM; CD4 ANTIBODY; CD40 LIGAND MONOCLONAL ANTIBODY; CD80 MONOCLONAL ANTIBODY; CD86 MONOCLONAL ANTIBODY; GLUCOSE; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; STREPTOZOCIN; UNCLASSIFIED DRUG; IMMUNOSUPPRESSIVE AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; EOSINOPHIL; FEMALE; GLUCOSE BLOOD LEVEL; GRAFT REJECTION; GRAFT SURVIVAL; HOST CELL; INSULIN DEPENDENT DIABETES MELLITUS; INTRAVENOUS GLUCOSE TOLERANCE TEST; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MICROCAPSULE; MICROENCAPSULATION; MOUSE; NEUTROPHIL CHEMOTAXIS; NOD SCID MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET TRANSPLANTATION; PERITONEUM CELL; PRIORITY JOURNAL; T CELL DEPLETION; TILAPIA; XENOGRAFT; ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; IMMUNOLOGY; PANCREAS ISLET; PIG; PROCEDURES; SCID MOUSE;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED NOD; MICE, SCID; SWINE; TILAPIA; TRANSPLANTATION, HETEROLOGOUS;

EID: 84899442413     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12086     Document Type: Article

References (38)

1. Shapiro J, Lakey J, Ryan E, et al. Islet transplantation in seven patients with Type I diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Eng J Med 2000; 343: 230-290.
2. Ryan EA, Lakey JR, Paty BW, et al. Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes 2002; 51: 2148-2157.
3. Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54: 2060-2069.
4. Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006; 355: 1318-1330.
5. Bellin MD, Barton FB, Heitman A, et al. Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in Type 1 diabetes. Am J Transp 2012; 12: 1576-1583.
6. Weber C, Yres-Price J, Costanzo M, Becker A, Stall A,. NOD mouse peritoneal cellular response to poly-L-lysine-alginate microencapsulated rat islets. Transp Proc 1994; 26: 1116-1119.
7. Weber CJ, Zabinski S, Koschitzky T, et al. Microencapsulated dog and rat islet xenografts into streptozotocin-diabetic and NOD mice. Horm Metab Res 1990; 25: 219-226.
8. Weber CJ, Hagler MK, Chryssochoos JT, et al. CTLA4-Ig prolongs survival of microencapsulated rabbit islet xenografts in spontaneously diabetic NOD mice. Transp Proc 1996; 28: 821-823.
9. Safley SA, Kapp JA, Weber CJ,. Proliferative and cytokine responses in CTLA4-Ig-treated diabetic NOD mice transplanted with microencapsulated neonatal porcine ICCs. Cell Transplant 2002; 11: 695-705.
10. Safley SA, Kapp LM, Tucker-Burden C, et al. Inhibition of cellular immune responses to encapsulated porcine islet xenografts by simultaneous blockade of two different costimulatory pathways. Transplantation 2005; 79: 409-418.
11. Safley SA, Kapp L, Tucker-Burden C, et al. Chronic treatment with CTLA4-Ig and MR1 prolongs the survival of encapsulated porcine islet xenografts in diabetic NOD mice. FASEB J 2004; 18: A1180.
12. Safley SA, Kapp L, Tucker-Burden C, et al. Chronic dual costimulatory blockade causes long-term survival of encapsulated porcine islet xenografts, but not tolerance, in NOD mice. FASEB J 2005; 19: A333.
13. Weber CJ, Zabinski S, Koschitzky T, et al. The role of CD4+ helper T cells in the destruction of microencapsulated islet xenografts in NOD mice. Transplantation 1990; 49: 396-404.
14. Yang H, Wright JR Jr,. A method for mass harvesting islets (Brockmann bodies) from teleost fish. Cell Transplant 1995; 4: 621-628.
15. Wright JR Jr, Bonen A, Conlon JM, Pohajdak B,. Glucose homeostasis in the teleost fish tilapia: insights from Brockmann body xenotransplantation studies. Am Zool 2000; 40: 234-245.
16. Wright JR Jr, Yang H, Dooley KC,. Tilapia-a source of hypoxia-resistant islet cells for encapsulation. Cell Transplant 1998; 7: 299-307.
17. Goh F, Sambanis A,. In vivo noninvasive monitoring of dissolved oxygen concentration within an implanted tissue-engineered pancreatic construct. Tissue Eng Part C Methods 2011; 17: 887-894.
18. Wright JR Jr, Pohajdak B,. Cell therapy for diabetes using piscine islet tissue. Cell Transplant 2001; 10: 125-143.
19. Wright JR Jr, Pohajdak B, Xu BY, Leventhal JR,. Piscine islet xenotransplantation. ILAR J 2004; 45: 314-323.
20. Weber C, Weil R, McIntosh R, et al. Xenotransplantation of piscine islets into hyperglycemic rats. Surgery 1975; 77: 208-215.
21. Schrezenmeir J, Laue C, Boddin J, et al. Frontiers in Diabetes Research Lessons from animal diabetes II. London: John Libbey, 1988.
22. Schrezenmeir J, Faust P, Laue C, et al. Immunoprotection by biocompatible membranes permits transplantation of piscine islets into rats. Transp Proc 1989; 21: 2730-2735.
23. Wright JR Jr, Polvi S, Maclean H,. Experimental transplantation with principal islets of teleost fish (Brockmann bodies): long-term function of tilapia islet tissue in diabetic nude mice. Diabetes 1992; 41: 1528-1533.
24. Xu BY, Yang H, Serreze DV, et al. Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles. Transplantation 2005; 80: 402-409.
25. Cui H, Tucker-Burden C, Cauffiel SMD, et al. Long-term metabolic control of autoimmune diabetes in spontaneously diabetic NOD mice by non-vascularized microencapsulated adult porcine islets. Transplantation 2009; 88: 160-169.
26. Yang H, Hali W, Kearns H, Wright JR Jr,. Long-term function of fish islet xenografts in mice by alginate encapsulation. Transplantation 1997; 64: 28-32.
27. Kulseng B, Thu B, Espevik T,. SKJAK-BR†EK G. Alginate polylysine microcapsules as immune barrier: permeability of cytokines and immunoglobulines over the capsule membrane. Cell Transplant 1997; 6: 387-394.
28. Linsley P, Brady W, Urnes M, Grosmaire L, Damle N,. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 1991; 174: 561-569.
29. Jenkins MK, Taylor PS, Norton SD, Urdahl KB,. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. J Immunol 1991; 147: 2461-2466.
30. de Vos P, de Haan BJ, Wolters GHJ, Strubbe JH, van Schilfgaarde R,. Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets. Diabetologia 1997; 40: 262-270.
31. de Haan BJ, Faas MM, de Vos P,. Factors influencing insulin secretion from encapsulated islets. Cell Transplant 2003; 12: 617-625.
32. Hrytsenko O, Wright JR Jr, Pohajdak B,. Regulation of insulin gene expression and insulin production in Nile tilapia (Oreochromis niloticus). Gen Comp Endocrinol 2008; 155: 328-340.
33. Nguyen T, Wright JR Jr, Nielsen PF, Conlon JM,. Characterization of the pancreatic hormones from the Borckmann body of the tilapia: implications to the islet xenograft studies. Comp Biochem Physiol 1995; 111C: 33-44.
34. Mansour M, Wright JR Jr, Pohajdak B,. Cloning, sequencing, and characterization of the tilapia insulin gene. Comp Biochem Physiol B 1998; 121: 291-297.
35. Pohajdak B, Mansour M, Hrytsenko O, et al. Production of transgenic tilapia with Brockman bodies secreting [desThrB30] human insulin. Transgenic Res 2004; 13: 313-323.
36. Wright JR Jr, Snowdon J, Hrytsenko O, Morrison CM, Pohajdak B,. Immunohistochemical staining for tilapia and human insulin demonstrates that a tilapia transgenic for humanized insulin is a mosaic. Transgenic Res 2008; 17: 992.
37. Hrytsenko O, Pohajdak B, Wright JR Jr,. Production of transgenic tiilapia homozygous for a humanized insulin gene. Transgenic Res 2010; 19: 305-306.
38. Hrytsenko O, Rayat GR, Xu BY, et al. Lifelong stable human insulin expression in transgenic tilapia expressing a humanized tilapia insulin gene. Transgenic Res 2011; 20: 1397-1398.