Lifelong stable human insulin expression in transgenic tilapia expressing a humanized tilapia insulin gene

Transgenic Research

Volumn 20, Issue 6, 2011, Pages 1397-1398

  Hrytsenko, Olga ^a   Rayat, Gina R ^b   Xu, Bao You ^c   Krause, Richard ^c,d   Pohajdak, Bill ^a   Rajotte, Ray V ^b   Wright Jr , James R ^c,d  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

^d CALGARY LABORATORY SERVICES   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ANIMAL; BLOOD; GENE EXPRESSION; GENETICS; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; LETTER; METABOLISM; TILAPIA; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOOD GLUCOSE; GENE EXPRESSION; GENOTYPE; HUMANS; INSULIN; TILAPIA;

TILAPIA;

EID: 80855143782     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-011-9500-3     Document Type: Letter

References (5)

1. Hrytsenko O, Pohajdak B, Wright JR Jr (2010) Production of transgenic tilapia homozygous for a humanized insulin gene. Transgenic Res 19(2): 305-306.
2. Pohajdak B, Mansour M, Hrytsenko O, Conlon JM, Dymond C, Wright JR Jr (2004) Production of transgenic tilapia with Brockmann bodies secreting [desThrB30] human insulin. Transgenic Res 13(4): 313-323.
3. Wright JR Jr, Hrytsenko O, Pohajdak B (2011) Transgenic tilapia for islet xenotransplantation. In: Fletcher G, Rise M (ed), Aquaculture Biotechnology, Wiley-Blackwell Publications, Hoboken, NJ (in press).
4. Wright JR Jr, Bonen A, Conlon JM, Pohajdak B (2000) Glucose homeostasis in the teleost fish tilapia: insights from Brockmann body xenotransplantation studies. Am Zool 40: 234-245.
5. Wright JR Jr, Snowden J, Hrytsenko O, Morrison CM, Pohajdak B (2008) Immunohistochemical staining for tilapia and human insulin demonstrates that a tilapia transgenic for humanized insulin is a mosaic. Transgenic Res 17(5): 991-992.