Dabigatran etexilate for secondary stroke prevention: The first year experience from a multicenter short-term registry

Therapeutic Advances in Neurological Disorders

Volumn 7, Issue 3, 2014, Pages 155-161

  Tsivgoulis, Georgios ^a   Krogias, Christos ^b   Sands, Kara A ^c   Sharma, Vijay K ^d   Katsanos, Aristeidis H ^e   Vadikolias, Konstantinos ^f   Heliopoulos, Ioannis ^f   Mitsoglou, Athina ^f   Giannopoulos, Sotirios ^f   Piperidou, Charitomeni ^f   Voumvourakis, Konstantinos ^f   Alexandrov, Andrei V ^f   Papageorgiou, Sokratis G ^a   Shiue, Harn ^c   Athanasiadis, Dimitrios ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b ST JOSEF HOSPITAL   (Germany)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^e UNIVERSITY OF IOANNINA   (Greece)

^f DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

atrial fibrillation; dabigatran etexilate; secondary prevention; stroke; transient ischemic attack

Indexed keywords

DABIGATRAN ETEXILATE; WARFARIN;

AGED; ANTICOAGULANT THERAPY; ARTICLE; BLOATING; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CHADS2 SCORE; DRUG COST; DRUG EFFICACY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPEPSIA; EMBOLISM; EMBOLISM PREVENTION; FEMALE; FLATULENCE; FOLLOW UP; GASTROINTESTINAL HEMORRHAGE; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEMATURIA; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL SOCIETY; MEDICATION COMPLIANCE; MULTICENTER STUDY; PATIENT COMPLIANCE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECTUM HEMORRHAGE; SECONDARY PREVENTION; SYSTEMIC EMBOLISM; TERTIARY HEALTH CARE; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME;

EID: 84899432097     PISSN: 17562856     EISSN: 17562864     Source Type: Journal    
DOI: 10.1177/1756285614528064     Document Type: Article

References (25)

1. Alberts M. Bernstein R. Naccarelli G. Garcia D. (2012) Using dabigatran in patients with stroke: a practical guide for clinicians. Stroke 43: 271–279.
2. Banerjee A. Marin F. Lip G. (2011) A new landscape for stroke prevention in atrial fibrillation: focus on new anticoagulants, antiarrhythmic drugs, and devices. Stroke 42: 3316–3322.
3. Bene J. Said W. Rannou M. Deheul S. Coupe P. Gautier S. (2012) rectal bleeding and hemostatic disorders induced by dabigatran etexilate in 2 elderly patients. Ann Pharmacother 46: e14.
4. Connolly S. Ezekowitz M. Yusuf S. Eikelboom J. Oldgren J. Parekh A. et al. (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361: 1139–1151.
5. Diener H. Connolly S. Ezekowitz M. Wallentin L. Reilly P. Yang S. et al. (2010) Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY Trial. Lancet Neurol 9: 1157–1163.
6. Ezekowitz M. Connolly S. Parekh A. Reilly P. Varrone J. Wang S. et al. (2009) Rationale and design of RE-LY: randomized evaluation of long-term anticoagulant therapy, warfarin, compared with dabigatran. Am Heart J 157: 805–810, 810 e801–802.
7. Freeman J. Zhu R. Owens D. Garber A. Hutton D. Go A. et al. (2011) Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation. Ann Intern Med 154: 1–11.
8. Gage B. van Walraven C. Pearce L. Hart R. Koudstaal P. Boode B. et al. (2004) Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirin. Circulation 110: 2287–2292.
9. Glund S. Stangier J. Schmohl M. de Smet M. Gansser D. Lang B. et al. (2013) A specific antidote for dabigatran: immediate, complete and sustained reversal of dabigatran induced anticoagulation in healthy male volunteers. Circulation 128: A17765
10. Harper P. Young L. Merriman E. (2012) bleeding risk with dabigatran in the frail elderly. N Engl J Med 366: 864–866.
11. Holster I. Valkhoff V. Kuipers E. Tjwa E. (2013) New oral anticoagulants increase risk for gastrointestinal bleeding: a systematic review and meta-analysis. Gastroenterology 145:105–112.e15
12. Husari A. Beydoun A. Sheik Ammar A. Maakaron J. Taher A. (2013) the untold story of dabigatran etexilate: alveolar hemorrhage in an elderly patient with interstitial pulmonary fibrosis. J Thromb Thrombolysis 35: 81–82.
13. Jacobs J. Stessman J. (2011) New anticoagulant drugs among elderly patients. Is caution necessary? Comment on ‘the use of dabigatran in elderly patients’. Arch Intern Med 171: 1287–1288.
14. Larsen T. Rasmussen L. Skjoth F. Due K. Callreus T. Rosenzweig M. et al. (2013) Efficacy and safety of dabigatran etexilate and warfarin in ‘real-world’ patients with atrial fibrillation: a prospective nationwide cohort study. J Am Coll Cardiol 61: 2264–2273.
15. Legrand M. Mateo J. Aribaud A. Ginisty S. Eftekhari P. Huy P. et al. (2011) The use of dabigatran in elderly patients. Arch Intern Med 171: 1285–1286.
16. Southworth M. Reichman M. Unger E. (2013) Dabigatran and postmarketing reports of bleeding. N Engl J Med 368: 1272–1274.
17. Stollberger C. Finsterer J. (2012 a) Concerns about studies investigating new anticoagulant drugs for stroke prevention in atrial fibrillation. J Neurol 259: 168–169.
18. Stollberger C. Finsterer J. (2012 b) Concerns regarding the use of dabigatran for stroke prevention in atrial fibrillation. Pharmaceuticals 5: 155–168.
19. Tsivgoulis G. Kerasnoudis A. Krogias C. Vadikolias K. Meves S. Heliopoulos I. et al. (2012) Clopidogrel load for emboli reduction in patients with symptomatic carotid stenosis undergoing urgent carotid endarterectomy. Stroke 43: 1957–1960.
20. Tsivgoulis G. Stamboulis E. Sharma V. Heliopoulos I. Voumvourakis K. Teoh H. et al. (2010) Multicenter external validation of the ABCD2 score in triaging TIA patients. Neurology 74: 1351–1357.
21. Tsivgoulis G. Stamboulis E. Sharma V. Heliopoulos I. Voumvourakis K. Teoh H. et al. (2011) Safety of transcranial doppler ‘bubble study’ for identification of right to left shunts: an international multicentre study. J Neurol Neurosurg Psychiatry 82: 1206–1208.
22. Wann L. Curtis A. January C. Ellenbogen K. Lowe J. Estes N. III et al. (2011) 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (updating the 2006 guideline): a report of the American College of Cardiology Foundation / American Heart Association Task Force on Practice Guidelines. Circulation 123: 104–123.
23. Weimar C. Hohnloser S. Eikelboom J. Diener H. (2012) Preventing cardioembolic stroke in atrial fibrillation with dabigatran. Curr Neurol Neurosci Rep 12: 17–23.
24. Wychowski M. Kouides P. (2012) Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment. Ann Pharmacother 46: e10.
25. Zhao L. Barlinn K. Sharma V. Tsivgoulis G. Cava L. Vasdekis S. et al. (2011) Velocity criteria for intracranial stenosis revisited: an international multicenter study of transcranial doppler and digital subtraction angiography. Stroke 42: 3429–3434.