Human chorionic gonadotropin, angiogenic factors, and preeclampsia risk: A nested case-control study

Acta Obstetricia et Gynecologica Scandinavica

Volumn 93, Issue 5, 2014, Pages 454-462

  Åsvold, Bjørn O ^a,b   Eskild, Anne ^c,d   Vatten, Lars J ^a,e  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

angiogenesis; Human chorionic gonadotropin; hypertension in pregnancy; placental growth factor; preeclampsia; soluble fms like tyrosine kinase 1

Indexed keywords

CHORIONIC GONADOTROPIN; PLACENTAL GROWTH FACTOR; SOLUBLE FMS LIKE TYROSINE KINASE 1; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ADULT; ANGIOGENESIS; ARTICLE; BLOOD SAMPLING; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MATERNAL AGE; MATERNAL HYPERTENSION; MATERNAL SERUM; NULLIPARA; PREECLAMPSIA; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; RISK; RISK ASSESSMENT;

ANGIOGENESIS; HUMAN CHORIONIC GONADOTROPIN; HYPERTENSION IN PREGNANCY; PLACENTAL GROWTH FACTOR; PREECLAMPSIA; SOLUBLE FMS-LIKE TYROSINE KINASE 1;

ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHORIONIC GONADOTROPIN; FEMALE; GESTATIONAL AGE; HUMANS; NORWAY; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY PROTEINS; PREGNANCY TRIMESTERS; PREMATURE BIRTH; RISK FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; YOUNG ADULT;

EID: 84899423008     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1111/aogs.12363     Document Type: Article

References (30)

1. Chandra S, Scott H, Dodds L, Watts C, Blight C, Van Den Hof M,. Unexplained elevated maternal serum alpha-fetoprotein and/or human chorionic gonadotropin and the risk of adverse outcomes. Am J Obstet Gynecol. 2003; 189: 775-81.
2. Dugoff L, Hobbins JC, Malone FD, Vidaver J, Sullivan L, Canick JA, et al. Quad screen as a predictor of adverse pregnancy outcome. Obstet Gynecol. 2005; 106: 260-7.
3. Morris RK, Cnossen JS, Langejans M, Robson SC, Kleijnen J, Ter Riet G, et al. Serum screening with Down's syndrome markers to predict pre-eclampsia and small for gestational age: systematic review and meta-analysis. BMC Pregnancy Childbirth. 2008; 8: 33.
4. Olsen RN, Woelkers D, Dunsmoor-Su R, Lacoursiere DY,. Abnormal second-trimester serum analytes are more predictive of preterm preeclampsia. Am J Obstet Gynecol. 2012; 207:228. e1-7.
5. Said ME, Campbell DM, Azzam ME, MacGillivray I,. Beta-human chorionic gonadotrophin levels before and after the development of pre-eclampsia. Br J Obstet Gynaecol. 1984; 91: 772-5.
6. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006; 355: 992-1005.
7. Romero R, Nien JK, Espinoza J, Todem D, Fu W, Chung H, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med. 2008; 21: 9-23.
8. Vatten LJ, Eskild A, Nilsen TI, Jeansson S, Jenum PA, Staff AC,. Changes in circulating level of angiogenic factors from the first to second trimester as predictors of preeclampsia. Am J Obstet Gynecol. 2007; 196:239. e1-6.
9. Zygmunt M, Herr F, Munstedt K, Lang U, Liang OD,. Angiogenesis and vasculogenesis in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2003; 110 (Suppl 1): S10-8.
10. Berndt S, Perrier d'Hauterive S, Blacher S, Pequeux C, Lorquet S, Munaut C, et al. Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium. FASEB J. 2006; 20: 2630-2.
11. Brouillet S, Hoffmann P, Chauvet S, Salomon A, Chamboredon S, Sergent F, et al. Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors. Cell Mol Life Sci. 2012; 69: 1537-50.
12. Neulen J, Yan Z, Raczek S, Weindel K, Keck C, Weich HA, et al. Human chorionic gonadotropin-dependent expression of vascular endothelial growth factor/vascular permeability factor in human granulosa cells: importance in ovarian hyperstimulation syndrome. J Clin Endocrinol Metab. 1995; 80: 1967-71.
13. Jenum PA, Stray-Pedersen B, Melby KK, Kapperud G, Whitelaw A, Eskild A, et al. Incidence of Toxoplasma gondii infection in 35,940 pregnant women in Norway and pregnancy outcome for infected women. J Clin Microbiol. 1998; 36: 2900-6.
14. Vatten LJ, Asvold BO, Eskild A,. Angiogenic factors in maternal circulation and preeclampsia with or without fetal growth restriction. Acta Obstet Gynecol Scand. 2012; 91: 1388-94.
15. Heikkila A, Makkonen N, Heinonen S, Kirkinen P,. Elevated maternal serum hCG in the second trimester increases prematurity rate and need for neonatal intensive care in primiparous preeclamptic pregnancies. Hypertens Pregnancy. 2001; 20: 99-106.
16. Hsu CD, Chan DW, Iriye B, Johnson TR, Hong SF, Repke JT,. Elevated serum human chorionic gonadotropin as evidence of secretory response in severe preeclampsia. Am J Obstet Gynecol. 1994; 170: 1135-8.
17. Lee LC, Sheu BC, Shau WY, Liu DM, Lai TJ, Lee YH, et al. Mid-trimester beta-hCG levels incorporated in a multifactorial model for the prediction of severe pre-eclampsia. Prenat Diagn. 2000; 20: 738-43.
18. Towner D, Gandhi S, El Kady D,. Obstetric outcomes in women with elevated maternal serum human chorionic gonadotropin. Am J Obstet Gynecol. 2006; 194: 1676-81; discussion 81-2.
19. Canini S, Prefumo F, Pastorino D, Crocetti L, Afflitto CG, Venturini PL, et al. Association between birth weight and first-trimester free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A. Fertil Steril. 2008; 89: 174-8.
20. Keikkala E, Vuorela P, Laivuori H, Romppanen J, Heinonen S, Stenman UH,. First trimester hyperglycosylated human chorionic gonadotrophin in serum-a marker of early-onset preeclampsia. Placenta. 2013; 34: 1059-65.
21. Ong CY, Liao AW, Spencer K, Munim S, Nicolaides KH,. First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. BJOG. 2000; 107: 1265-70.
22. Smith GC, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor JM,. Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metab. 2002; 87: 1762-7.
23. Spencer K, Cowans NJ, Nicolaides KH,. Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia. Prenat Diagn. 2008; 28: 7-10.
24. Wortelboer EJ, Koster MP, Cuckle HS, Stoutenbeek PH, Schielen PC, Visser GH,. First-trimester placental protein 13 and placental growth factor: markers for identification of women destined to develop early-onset pre-eclampsia. BJOG. 2010; 117: 1384-9.
25. Berndt S, Blacher S, Perrier d'Hauterive S, Thiry M, Tsampalas M, Cruz A, et al. Chorionic gonadotropin stimulation of angiogenesis and pericyte recruitment. J Clin Endocrinol Metab. 2009; 94: 4567-74.
26. Cole LA,. Biological functions of hCG and hCG-related molecules. Reprod Biol Endocrinol. 2010; 8: 102.
27. Thadhani R, Mutter WP, Wolf M, Levine RJ, Taylor RN, Sukhatme VP, et al. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab. 2004; 89: 770-5.
28. Gomez R, Soares SR, Busso C, Garcia-Velasco JA, Simon C, Pellicer A,. Physiology and pathology of ovarian hyperstimulation syndrome. Semin Reprod Med. 2010; 28: 448-57.
29. Molskness TA, Stouffer RL, Burry KA, Gorrill MJ, Lee DM, Patton PE,. Circulating levels of free and total vascular endothelial growth factor (VEGF)-A, soluble VEGF receptors-1 and -2, and angiogenin during ovarian stimulation in non-human primates and women. Hum Reprod. 2004; 19: 822-30.
30. Crosignani PG, Trojsi L, Attanasio AE, Finzi GC,. Value of HCG and HCS measurement in clinical practice. Obstet Gynecol. 1974; 44: 673-81.