Comparative analysis of the effects of packaging signal, transgene orientation, promoters, polyadenylation signals, and E3 region on growth properties of first-generation adenoviruses

Human Gene Therapy

Volumn 14, Issue 10, 2003, Pages 1017-1034

  Youil, Rima ^a   Tang, Aimin ^a   Chen, Michelle ^a   Emini, Emilio A ^a   Kaslow, David C ^a,c   Aunins, John G ^a   Altaras, Nedim E ^a   Toner, Timothy J ^a   Su, Qin ^a   Casimiro, Danilo ^a   Shiver, John W ^a   Chen, Ling ^a,b   Bett, Andrew J ^a   Rogers, Bethany M ^a   Burden, Eric C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b LEXICON PHARMACEUTICALS INC   (United States)

^c Vical   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GAG PROTEIN; PLASMID DNA; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA PACKAGING; DRUG EFFECT; DRUG EFFICACY; FEMALE; GENE AMPLIFICATION; GENE CONSTRUCT; GENE DELETION; GENETIC STABILITY; MOUSE; NONHUMAN; PLASMID; POLYADENYLATION; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSGENE; VIROGENESIS;

ADENOVIRIDAE; ADENOVIRUS E1A PROTEINS; ADENOVIRUS E3 PROTEINS; ANIMALS; CAPSID PROTEINS; CYTOMEGALOVIRUS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION, VIRAL; GENES, GAG; GENETIC VECTORS; GENOME, VIRAL; IMMEDIATE-EARLY PROTEINS; MEMBRANE PROTEINS; MICE; PLASMIDS; PROMOTER REGIONS (GENETICS); RNA 3' POLYADENYLATION SIGNALS; TRANSGENES; VIRUS ASSEMBLY;

ADENOVIRIDAE; ANIMALIA;

EID: 0038235693     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303403766682278     Document Type: Article

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