Differential expression and effect of the porcine ANGPTL4 gene on intramuscular fat

Genetics and Molecular Research

Volumn 13, Issue 2, 2014, Pages 2949-2958

  Ren, Z Q ^a   Wu, W J ^a,b   Liu, W H ^a   Zheng, R ^a   Li, J L ^a   Zuo, B ^a   Xu, D Q ^a   Li, F E ^a   Lei, M G ^a   Ni, D B ^a   Xiong, Y Z ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

ANGPTL4; Association analysis; Differential expression; Intramuscular fat; Pigs

Indexed keywords

ADENINE; GUANINE; MESSENGER RNA; WATER; ANGIOPOIETIN; ANGPTL4 PROTEIN, HUMAN;

ADIPOSE TISSUE; ANGPTL4 GENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FAT MASS; FEMALE; GENE; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; HEART; INTRAMUSCULAR FAT; INTRON; LARGE WHITE PIG; LONGISSIMUS DORSI; MALE; MEAT; MEAT MARBLING; MEISHAN PIG; MOISTURE; NONHUMAN; PH; PHASE TRANSITION; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SKELETAL MUSCLE; TISSUE DISTRIBUTION; UPREGULATION; ANIMAL; BODY FAT DISTRIBUTION; EXPRESSED SEQUENCE TAG; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETICS; HUMAN; METABOLISM; SWINE;

ANGIOPOIETINS; ANIMALS; BODY FAT DISTRIBUTION; EXPRESSED SEQUENCE TAGS; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION STUDIES; HUMANS; MEAT; MUSCLE, SKELETAL; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SUS SCROFA; SWINE;

EID: 84899148995     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2014.April.16.3     Document Type: Article

References (25)

1. Bäckhed F, Ding H, Wang T, Hooper LV, et al. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U. S. A. 101: 15718-15723.
2. Breathnach R, Benoist C, O'Hare K, Gannon F, et al. (1978). Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc. Natl. Acad. Sci. U. S. A. 75: 4853-4857.
3. Caserta F, Tchkonia T, Civelek VN, Prentki M, et al. (2001). Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am. J. Physiol. Endocrinol. Metab. 280: E238-E247.
4. Hato T, Tabata M and Oike Y (2008). The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc. Med. 18: 6-14.
5. Hocquette JF, Gondret F, Baéza E, Médale F, et al. (2010). Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers. Animal 4: 303-319.
6. Hovenier R, Kanis E and Verhoeven JA (1993). Repeatability of taste panel tenderness scores and their relationships to objective pig meat quality traits. J. Anim. Sci. 71: 2018-2025.
7. Kersten S (2005). Regulation of lipid metabolism via angiopoietin-like proteins. Biochem. Soc. Trans. 33: 1059-1062.
8. Kersten S, Mandard S, Tan NS, Escher P, et al. (2000). Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J. Biol. Chem. 275: 28488-28493.
9. Kim I, Kim HG, Kim H, Kim HH, et al. (2000). Hepatic expression, synthesis and secretion of a novel fibrinogen/ angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem. J. 346 (Pt 3): 603-610.
10. Koishi R, Ando Y, Ono M, Shimamura M, et al. (2002). Angptl3 regulates lipid metabolism in mice. Nat. Genet. 30: 151-157.
11. Koliwad SK, Kuo T, Shipp LE, Gray NE, et al. (2009). Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. J. Biol. Chem. 284: 25593-25601.
12. △△Ct method. Methods 25: 402-408.
13. Mandard S, Zandbergen F, van Straten E, Wahli W, et al. (2006). The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J. Biol. Chem. 281: 934-944.
14. Mead JR, Irvine SA and Ramji DP (2002). Lipoprotein lipase: structure, function, regulation, and role in disease. J. Mol. Med. 80: 753-769.
15. Merkel M, Eckel RH and Goldberg IJ (2002). Lipoprotein lipase: genetics, lipid uptake, and regulation. J. Lipid Res. 43: 1997-2006.
16. Oike Y, Akao M, Kubota Y and Suda T (2005). Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy. Trends Mol. Med. 11: 473-479.
17. Pethick DW, Harper GS and Oddy VH (2004). Growth, development and nutritional manipulation of marbling in cattle: A review. Aust. J. Exp. Agric. 44: 705-715.
18. Ren ZQ, Xiong YZ, Deng CY, Zuo B, et al. (2005). Age-dependent changes of differential gene expression profile in backfat tissue between hybrids and parents in pigs. Asian-Aust. J. Anim. Sci. 18: 682-685.
19. Romeo S, Pennacchio LA, Fu Y, Boerwinkle E, et al. (2007). Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat. Genet. 39: 513-516.
20. Shimizugawa T, Ono M, Shimamura M, Yoshida K, et al. (2002). ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. J. Biol. Chem. 277: 33742-33748.
21. Sukonina V, Lookene A, Olivecrona T and Olivecrona G (2006). Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc. Natl. Acad. Sci. U. S. A. 103: 17450-17455.
22. Wiesner G, Morash BA, Ur E and Wilkinson M (2004). Food restriction regulates adipose-specific cytokines in pituitary gland but not in hypothalamus. J. Endocrinol. 180: R1-R6.
23. Wood JD, Enser M, Fisher AV, Nute GR, et al. (2008). Fat deposition, fatty acid composition and meat quality: A review. Meat Sci. 78: 343-358.
24. Yoon JC, Chickering TW, Rosen ED, Dussault B, et al. (2000). Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol. Cell. Biol. 20: 5343-5349.
25. Yoshida K, Shimizugawa T, Ono M and Furukawa H (2002). Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J. Lipid Res. 43: 1770-1772.