Near-infrared fluorescence imaging of murine atherosclerosis using an oxidized low density lipoprotein-targeted fluorochrome

International Journal of Cardiovascular Imaging

Volumn 30, Issue 1, 2014, Pages 221-231

  Lu, Tong ^a   Wen, Song ^a,b   Cui, Ying ^a   Ju, Sheng Hong ^a   Li, King C ^c   Teng, Gao Jun ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Inflammation; Near infrared fluorescence imaging; oxLDL

Indexed keywords

APOLIPOPROTEIN E; ATORVASTATIN; CHOLESTEROL; FLUOROCHROME; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; NIR 797; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN ANTIBODY; PHOSPHATE BUFFERED SALINE; POLYCLONAL ANTIBODY; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; AORTA ARCH; AORTA ATHEROSCLEROSIS; AORTA BIFURCATION; AORTA ROOT; ARTICLE; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORRELATION ANALYSIS; EX VIVO STUDY; FEASIBILITY STUDY; FLUORESCENCE IMAGING; FLUORESCENCE MICROSCOPE; IMMUNOFLUORESCENCE; IN VITRO STUDY; MACROPHAGE; MALE; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NEAR INFRARED FLUORESCENCE IMAGING; NEAR INFRARED IMAGING SYSTEM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SHORT COURSE THERAPY; SIGNAL NOISE RATIO; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTIBODIES; AORTA; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL LINE; CHOLESTEROL, DIETARY; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEASIBILITY STUDIES; FLUORESCENT DYES; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; ISOTHIOCYANATES; LIPOPROTEINS, LDL; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OPTICAL IMAGING; PLAQUE, ATHEROSCLEROTIC; PYRROLES; TIME FACTORS;

EID: 84899120500     PISSN: 15695794     EISSN: 15730743     Source Type: Journal    
DOI: 10.1007/s10554-013-0320-9     Document Type: Article

References (34)

1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD et al (2013) Heart disease and stroke statistics - 2013 update: a report from the American heart association. Circulation 127:e6-e245
2. Rekhter MD (2002) How to evaluate plaque vulnerability in animal models of atherosclerosis? Cardiovasc Res 54:36-41
3. Virmani R, Burke AP, Farb A, Kolodgie FD (2006) Pathology of the vulnerable plaque. J Am Coll Cardiol 47:C13-C18
4. Fuster V, Moreno PR, Fayad ZA, Corti R, Badimon JJ (2005) Atherothrombosis and high-risk plaque: Part I: evolving concepts. J Am Coll Cardiol 46:937-954 (Pubitemid 41316498)
5. Staub D, Partovi S, Schinkel AF, Coll B, Uthoff H (2011) Correlation of carotid artery atherosclerotic lesion echogenicity and severity at standard US with intraplaque neovascularization detected at contrast-enhanced US. Radiology 258:618-626
6. Partovi S, Loebe M, Aschwanden M, Baldi T, Jäger KA et al (2012) Contrast-enhanced ultrasound for assessing carotid atherosclerotic plaque lesions. AJR Am J Roentgenol 198:W13-W19
7. Lou X, Ma N, Ma L, Jiang WJ (2013) Contrast-enhanced 3T high-resolution MR imaging in symptomatic atherosclerotic basilar artery stenosis. AJNR Am J Neuroradiol 34:513-517
8. Starmans LW, van Duijnhoven SM, Rossin R, Aime S, Daemen MJ et al (2013) SPECT imaging of fibrin using fibrin-binding peptides. Contrast Media Mol Imaging 8:229-237
9. Nahrendorf M, Sosnovik DE, Weissleder R (2008) MR-optical imaging of cardiovascular molecular targets. Basic Res Cardiol 103:87-94 (Pubitemid 351356751)
10. Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK et al (2008) Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation 118:1802-1809
11. Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y et al (2011) Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques. Sci Transl Med 3:84ra45
12. Jaffer FA, Libby P, Weissleder R (2009) Optical and multimodality molecular imaging: insights into atherosclerosis. Arterioscler Thromb Vasc Biol 29:1017-1024
13. Steinberg D (2009) The ldl modification hypothesis of atherogenesis: an update. J Lipid Res 50:S376-S381
14. Matsuura E, Hughes GRV, Khamashta MA (2008) Oxidation of ldl and its clinical implication. Autoimmun Rev 7:558-566
15. Tsimikas S, Shortal BP, Witztum JL, Palinski W (2000) In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression. Arterioscler Thromb Vasc Biol 20:689-697 (Pubitemid 30151682)
16. Peluso I, Morabito G, Urban L, Ioannone F, Serafini M (2012) Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst. Endocr Metab Immune Disord Drug Targets 12:351-360
17. Wen S, Liu DF, Liu Z, Harris S, Yao YY et al (2012) Oxldl-targeted iron oxide nanoparticles for in vivo mri detection of perivascular carotid collar induced atherosclerotic lesions in apoe-deficient mice. J Lipid Res 53:829-838
18. Chuang KH, Wang HE, Chen FM, Tzou SC, Cheng CM et al (2010) Endocytosis of PEGylated agents enhances cancer imaging and anticancer efficacy. Mol Cancer Ther 9:1903-1912
19. Briley-Saebo KC, Shaw PX, Mulder WJM, Choi SH, Vucic E et al (2008) Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation 117:3206-3215
20. Dietrich T, Perlitz C, Licha K, Stawowy P, Atrott K et al (2007) Ed-b fibronectin (ed-b) can be targeted using a novel single chain antibody conjugate and is associated with macrophage accumulation in atherosclerotic lesions. Basic Res Cardiol 102:298-307 (Pubitemid 46909708)
21. Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ et al (2004) Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol 24:2307-2312 (Pubitemid 39658034)
22. Briley-Saebo KC, Cho YS, Shaw PX, Ryu SK, Mani V et al (2011) Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes. J Am Coll Cardiol 57:337-347
23. Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM et al (2011) Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med 365:2078-2087
24. Vaklavas C, Chatzizisis YS, Ziakas A, Zamboulis C, Giannoglou GD (2009) Molecular basis of statin-associated myopathy. Atherosclerosis 202:18-28
25. Shoenfeld Y, Wu R, Dearing LD, Matsuura E (2004) Are anti-oxidized low-density lipoprotein antibodies pathogenic or protective? Circulation 110:2552-2558 (Pubitemid 39453000)
26. Zhou X, Caligiuri G, Hamsten A, Lefvert AK, Hansson GK (2001) Ldl immunization induces t-cell - dependent antibody formation and protection against atherosclerosis. Arterioscler Thromb Vasc Biol 21:108-114 (Pubitemid 32061934)
27. Laczik R, Szodoray P, Veres K, Szomják E, CsÍpo{combining double acute accent} I et al (2011) Assessment of igg antibodies to oxidized ldl in patients with acute coronary syndrome. Lupus 20:730-735
28. Wu R, Nityanand S, Berglund L, Lithell H, Holm G (1997) Antibodies against cardiolipin and oxidatively modified ldl in 50-year-old men predict myocardial infarction. Arterioscler Thromb Vasc Biol 17:3159-3163 (Pubitemid 28016072)
29. Nagarajan S (2007) Anti-OxLDL IgG blocks OxLDL interaction with CD36, but promotes FcgammaR, CD32A-dependent inflammatory cell adhesion. Immunol Lett 108:52-61
30. Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R et al (2002) In vivo imaging of proteolytic activity in atherosclerosis. Circulation 105:2766-2771 (Pubitemid 34615149)
31. Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF et al (2010) Hybrid pet-optical imaging using targeted probes. Proc Natl Acad Sci 107:7910-7915
32. Jaffer FA, Calfon MA, Rosenthal A, Mallas G, Razansky RN et al (2011) Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury. J Am Coll Cardiol 57:2516-2526
33. Prati F, Regar E, Mintz GS, Arbustini E, Di Mario C et al (2010) Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. Eur Heart J 31:401-415
34. Jang IK, Tearney GJ, MacNeill B, Takano M, Moselewski F et al (2005) In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation 111:1551-1555 (Pubitemid 40470652)