Does long-term aspirin use increase the risk of neovascular age-related macular degeneration?

Expert Opinion on Drug Safety

Volumn 13, Issue 4, 2014, Pages 421-429

  Christen, William G ^a   Chew, Emily Y ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

Age related macular degeneration; Aspirin; Observational studies; Randomized trials

Indexed keywords

ACETYLSALICYLIC ACID;

ADVERSE OUTCOME; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CLINICAL PRACTICE; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DRUG SAFETY; DRUG USE; FOLLOW UP; HEART INFARCTION; HUMAN; LONG TERM EXPOSURE; MEDICAL RECORD REVIEW; OBSERVATIONAL STUDY; PAIN; PHYSICIAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETINA MACULA AGE RELATED DEGENERATION; REVIEW; RISK; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RISK REDUCTION; TREATMENT DURATION; TREATMENT OUTCOME; WOMEN'S HEALTH;

ASPIRIN; HUMANS; MACULAR DEGENERATION; OBSERVATIONAL STUDY AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK; RISK FACTORS;

EID: 84899110112     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2014.889680     Document Type: Review

References (44)

1. Friedman DS, O'Colmain BJ, Munoz B, et al. Prevalence of age-related macular degeneration in the united states. Arch Ophthalmol 2004;122(4):564-72
2. Ambati J, Fowler BJ. Mechanisms of age-related macular degeneration. Neuron 2012;75(1):26-39
3. Ramulu PY, West SK, Munoz B, et al. Driving cessation and driving limitation in glaucoma: the salisbury eye evaluation project. Ophthalmology 2009;116(10):1846-53
4. Popescu ML, Boisjoly H, Schmaltz H, et al. Age-related eye disease and mobility limitations in older adults. Invest Ophthalmol Vis Sci 2011;52(10):7168-74
5. West SK, Rubin GS, Broman AT, et al. How does visual impairment affect performance on tasks of everyday life? The SEE project. Salisbury eye evaluation. Arch Ophthalmol 2002;120(6):774-80
6. Bullimore MA, Bailey IL, Wacker RT. Face recognition in age-related maculopathy. Invest Ophthalmol Vis Sci 1991;32(7):2020-9
7. Klein BE, Moss SE, Klein R, et al. Associations of visual function with physical outcomes and limitations 5 years later in an older population: the beaver dam eye study. Ophthalmology 2003;110(4):644-50
8. Willis JR, Jefferys JL, Vitale S, Ramulu PY. Visual impairment, uncorrected refractive error, and accelerometer-defined physical activity in the united states. Arch Ophthalmol 2012;130(3):329-35
9. Ajani UA, Ford ES, Greenland KJ, et al. Aspirin use among U.S. adults: behavioral risk factor surveillance system. Am J Prev Med 2006;30(1):74-7
10. Pignone M, Anderson GK, Binns K, et al. Aspirin use among adults aged 40 and older in the united states: results of a national survey. Am J Prev Med 2007;32(5):403-7
11. US FOOD and Drug Administration (FDA). Aspirin: questions and answers. FDA website. Available from: http://www.fda.gov/drugs/resourcesforyou/consumers/ questionsanswers/ucm071879. htm [Last accessed 10 June]
12. Rothwell PM, Price JF, Fowkes FG, et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet 2012;379(9826):1602-12
13. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324(7329):71-86
14. Hennekens CH, Dalen JE. Aspirin in the treatment and prevention of cardiovascular disease: past and current perspectives and future directions. Am J Med 2013;126(5):373-8
15. Feman SS, Bartlett RE, Roth AM, Foos RY. Intraocular hemorrhage and blindness associated with systemic anticoagulation. JAMA 1972;220(10):1354-5
16. Bloome MA, Ruiz RS. Massive spontaneous subretinal hemorrhage. Am J Ophthalmol 1978;86(5):630-7
17. el Baba F, Jarrett WH II, Harbin TS Jr, et al. Massive hemorrhage complicating age-related macular degeneration. Clinicopathologic correlation and role of anticoagulants. Ophthalmology 1986;93(12):1581-92
18. Lewis H, Sloan SH, Foos RY. Massive intraocular hemorrhage associated with anticoagulation and age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 1988;226(1):59-64
19. Kingham JD, Chen MC, Levy MH. Macular hemorrhage in the aging eye: the effects of anticoagulants. N Engl J Med 1988;318(17):1126-7
20. Kinshuck D, Stevenson L. Complications of NSAID therapy in patients with macular disease. Surv Ophthalmol 1992;37(2):149-50
21. Kiernan DF, Hariprasad SM, Rusu IM, et al. Epidemiology of the association between anticoagulants and intraocular hemorrhage in patients with neovascular age-related macular degeneration. Retina 2010;30(10):1573-8
22. Hirvela H, Luukinen H, Laara E, et al. Risk factors of age-related maculopathy in a population 70 years of age or older. Ophthalmology 1996;103(6):871-7
23. Rudnicka AR, MacCallum PK, Whitelocke R, Meade TW. Circulating markers of arterial thrombosis and late-stage age-related macular degeneration: a case-control study. Eye (Lond) 2010;24(7):1199-206
24. Tilanus MA, Vaandrager W, Cuypers MH, et al. Relationship between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2000;238(6):482-5
25. Age-Related Eye Disease Study Research Group. Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: age-related eye disease study report number 3. Ophthalmology 2000; 107(12): 2224-32
26. Klein ML. Macular degeneration: is aspirin a risk for progressive disease? JAMA 1991;266(16):2279
27. Rcurrent choroidal neovascularization after argon laser photocoagulation for neovascular maculopathy. Macular photocoagulation study group. Arch Ophthalmol 1986;104(4):503-12
28. Persistent and recurrent neovascularization after krypton laser photocoagulation for neovascular lesions of age-related macular degeneration. Macular photocoagulation study group. Arch Ophthalmol 1990;108(6):825-31
29. Klein R, Klein BE, Jensen SC, et al. Medication use and the 5-year incidence of early age-related maculopathy: the beaver dam eye study. Arch Ophthalmol 2001;119(9):1354-9
30. de Jong PT, Chakravarthy U, Rahu M, et al. Associations between aspirin use and aging macula disorder: the european eye study. Ophthalmology 2012;119(1):112-18
31. Klein BE, Howard KP, Gangnon RE, et al. Long-term use of aspirin and age-related macular degeneration. JAMA 2012;308(23):2469-78
32. Liew G, Mitchell P, Wong TY, et al. The association of aspirin use with age-related macular degeneration. JAMA Intern Med 2013;173(4):258-64
33. Christen WG, Glynn RJ, Ajani UA, et al. Age-related maculopathy in a randomized trial of low-dose aspirin among US physicians. Arch Ophthalmol 2001;119(8):1143-9
34. Christen WG, Glynn RJ, Chew EY, Buring JE. Low-dose aspirin and medical record-confirmed age-related macular degeneration in a randomized trial of women. Ophthalmology 2009;116(12):2386-92
35. Snow KK, Seddon JM. Do age-related macular degeneration and cardiovascular disease share common antecedents? Ophthalmic Epidemiol 1999;6(2):125-43
36. Wong TY, Klein R, Sun C, et al. Age-related macular degeneration and risk for stroke. Ann Intern Med 2006;145(2):98-106
37. Duan Y, Mo J, Klein R, et al. Age-related macular degeneration is associated with incident myocardial infarction among elderly americans. Ophthalmology 2007;114(4):732-7
38. Wong TY, Tikellis G, Sun C, et al. Age-related macular degeneration and risk of coronary heart disease: the atherosclerosis risk in communities study. Ophthalmology 2007;114(1):86-91
39. Tan JS, Wang JJ, Liew G, et al. Age-related macular degeneration and mortality from cardiovascular disease or stroke. Br J Ophthalmol 2008;92(4):509-12
40. Sun C, Klein R, Wong TY. Age-related macular degeneration and risk of coronary heart disease and stroke: the cardiovascular health study. Ophthalmology 2009;116(10):1913-19
41. Hu CC, Ho JD, Lin HC. Neovascular age-related macular degeneration and the risk of stroke: a 5-year population-based follow-up study. Stroke 2010;41(4):613-17
42. Fernandez AB, Wong TY, Klein R, et al. Age-related macular degeneration and incident cardiovascular disease: the multi-ethnic study of atherosclerosis. Ophthalmology 2012;119(4):765-70
43. Ikram MK, Mitchell P, Klein R, et al. Age-related macular degeneration and long-term risk of stroke subtypes. Stroke 2012;43(6):1681-3
44. Rothman KJ. Modern epidemiology. Little, Brown, Boston; 1986