Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: A meta-analysis

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Zhao, Mengmeng ^a,b   Ren, Yangwu ^a,b   Shen, Li ^a,b   Zhang, Yue ^a,b   Zhou, Baosen ^a,b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b University of Liaoning Province   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; ASIAN; CASE CONTROL STUDY; CENTRAL ASIAN; CHILD HEALTH; CLEFT LIP; CLEFT LIP PALATE; EASTERN ASIAN; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GEOGRAPHIC ORIGIN; HUMAN; MOTHER; MTHFR GENE; NONSYNDROMIC CLEFT LIP PALATE; PATHOGENESIS; RISK ASSESSMENT; SYSTEMATIC REVIEW; WESTERN ASIAN; ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN; CHILD; CLEFT PALATE; FEMALE; GENETICS; META ANALYSIS;

METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN; CASE-CONTROL STUDIES; CHILD; CLEFT LIP; CLEFT PALATE; FEMALE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC;

EID: 84899099724     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088242     Document Type: Article

References (26)

1. World Health O (2003) Global registry and database on craniofacial anomalies: Report of a WHO registry meeting on craniofacial anomalies. Geneva: World Health Organization Report nr ISBN 651656510.
2. Mossey PA, Modell B (2012) Epidemiology of oral clefts 2012: an international perspective. Front Oral Biol 16: 1-18.
3. Schutte BC, Murray JC (1999) The many faces and factors of orofacial clefts. Hum Mol Genet 8: 1853-1859. (Pubitemid 29458662)
4. Tolarova M (1982) Periconceptional supplementation with vitamins and folic acid to prevent recurrence of cleft lip. Lancet 2: 217.
5. Hernández-Díaz S, Werler MM, Walker AM, Mitchell AA (2000) Folic acid antagonists during pregnancy and the risk of birth defects. New England journal of medicine 343: 1608-1614. (Pubitemid 32162984)
6. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, et al. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genetics 10: 111-113.
7. Bailey LB, Gregory JF 3rd (1999) Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. The Journal of nutrition 129: 919-922. (Pubitemid 29214439)
8. Van der Put NM, Gabreëls F, Stevens EM, Smeitink JA, Trijbels FJ, et al. (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? American journal of human genetics 62: 1044.
9. Mills JL, Molloy AM, Parle-McDermott A, Troendle JF, Brody LC, et al. (2008) Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate. Birth Defects Research Part A: Clinical and Molecular Teratology 82: 636-643.
10. Brandalize AP, Bandinelli E, Borba JB, Félix TM, Roisenberg I, et al. (2007) Polymorphisms in genes MTHFR, MTR and MTRR are not risk factors for cleft lip/palate in South Brazil. Brazilian Journal of Medical and Biological Research 40: 787-791. (Pubitemid 47009454)
11. van Rooij IA, Vermeij-Keers C, Kluijtmans LA, Ocké MC, Zielhuis GA, et al. (2003) Goorhuis-Brouwer SM, van der Biezen JJ, Kuijpers-Jagtman AM, RP ST: Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate? American journal of epidemiology 157: 583-591. (Pubitemid 36368528)
12. Boyles AL, Wilcox A, Taylor JA, Meyer K, Fredriksen A, et al. (2008) Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts. Am J Med Genet A 146A: 440-449. (Pubitemid 351206814)
13. Tolarova M, Van Rooij IALM, Pastor M, Van der Put NM, Goldberg AC, et al. (1998) A common mutation in the MTHFR gene is a risk factor for nonsyndromic cleft lip and palate anomalies. Am J Hum Genet 63: A27.
14. Shotelersuk V, Ittiwut C, Siriwan P, Angspatt A (2003) Maternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip. J Med Genet 40: e64.
15. Gaspar DA, Matioli SR, de Cássia Pavanello R, Araújo BC, Alonso N, et al. (2004) Maternal MTHFR interacts with the offspring's BCL3 genotypes, but not with TGFA, in increasing risk to nonsyndromic cleft lip with or without cleft palate. Eur J Hum Genet 12: 521-526. (Pubitemid 39077159)
16. Ali A, Singh SK, Raman R (2009) MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population. Genet Test Mol Biomarkers 13: 355-360.
17. Luo YL, Cheng YL, Ye P, Wang W, Gao XH, et al. (2012) Association between MTHFR polymorphisms and orofacial clefts risk: a meta-analysis. Birth Defects Res A Clin Mol Teratol 94:237-244.
18. Pan Y, Zhang W, Ma J, Du Y, Li D, et al. (2012) Infants' MTHFR polymorphisms and nonsyndromic orofacial clefts susceptibility: a meta-analysis based on 17 case-control studies. Am J Med Genet A 158A: 2162-2169.
19. Verkleij-Hagoort A, Bliek J, Sayed-Tabatabaei F, Ursem N, Steegers E, et al. (2007) Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis. Am J Med Genet A 143A: 952-960. (Pubitemid 46700901)
20. Johnson CY, Little J (2008) Folate intake, markers of folate status and oral clefts: is the evidence converging? Int J Epidemiol 37: 1041-1058.
21. Semiç-Jusufagiç A, Bircan R, Çelebiler Ö, Erdim M, Akarsu N, et al. (2012) Association between C677T and A1298C MTHFR Gene Polymorphism and Nonsyndromic Orofacial Clefts in the Turkish Population: A Case-Parent Study. Turk J Pediatr 54: 617-625.
22. Wang SM, Wang JH, Yu JC, Wei B, Wang KH, et al. (2012) Association between parental MTHFR gene polymorphism 677C/T and nonsyndromic cleft lip and palate in offspring. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29: 464-467.
23. Kumari P, Ali A, Sukla KK, Singh SK, Raman R (2013) Lower incidence of nonsyndromic cleft lip with or without cleft palate in females: is homocysteine a factor? J Biosci 38: 21-26.
24. Han Y, Pan Y, Du Y, Tong N, Wang M, et al. (2011) Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and nonsyndromic orofacial clefts susceptibility in a southern Chinese population. DNA and Cell Biology 30: 1063-1068.
25. Guo JZ, Song XM, Wang Y, Zhu WL, Li SQ, et al. (2009) Relationship between genetic polymorphisms of MTHFR C677T and nonsyndromic cleft lip with or without palate. Beijing Da Xue Xue Bao 41: 432-436.
26. Wan WD, Wang LJ, Zhou XP, Zhou DL, Zhang QG, et al. (2006) Relationship between nonsyndromic cleft lip with or without cleft palate (NSCL/P) and genetic polymorphisms of MTHFR C677T and A1298C. Zhonghua Zheng Xing Wai Ke Za Zhi 22: 8-11.