메뉴 건너뛰기




Volumn 2, Issue 3, 2014, Pages 421-427

Low INSL3 in Klinefelter syndrome is related to osteocalcin, testosterone treatment and body composition, as well as measures of the hypothalamic-pituitary-gonadal axis

Author keywords

Body composition; Hypogonadism; Hypothalamus pituitary testicular bone axis; Leydig cell function; Metabolic syndrome

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; ESTRADIOL; FOLLITROPIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INSULIN LIKE FACTOR 3; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; MESTEROLONE; OSTEOCALCIN; PARATHYROID HORMONE; PEPTIDE HORMONE; SEX HORMONE BINDING PROTEIN; TESTOSTERONE; TESTOSTERONE UNDECANOATE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VITAMIN D; CELL SURFACE RECEPTOR; GLUCOSE BLOOD LEVEL; LEYDIG INSULIN-LIKE PROTEIN; LIPID; PROTEIN; SEX HORMONE-BINDING GLOBULIN RECEPTOR;

EID: 84899093763     PISSN: 20472919     EISSN: 20472927     Source Type: Journal    
DOI: 10.1111/j.2047-2927.2014.00204.x     Document Type: Article
Times cited : (35)

References (33)
  • 1
    • 21244461989 scopus 로고    scopus 로고
    • Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis
    • Bay K, Hartung S, Ivell R, Schumacher M, Jürgensen D, Jorgensen N et al. (2005) Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis. J Clin Endocrinol Metab 90, 3410-3418.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3410-3418
    • Bay, K.1    Hartung, S.2    Ivell, R.3    Schumacher, M.4    Jürgensen, D.5    Jorgensen, N.6
  • 2
    • 33644826521 scopus 로고    scopus 로고
    • The effects of gonadotropin suppression and selective replacement on insulin-like factor 3 secretion in normal adult men
    • Bay K, Matthiesson KL, McLachlan RI & Andersson AM. (2006) The effects of gonadotropin suppression and selective replacement on insulin-like factor 3 secretion in normal adult men. J Clin Endocrinol Metab 91, 1108-1111.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1108-1111
    • Bay, K.1    Matthiesson, K.L.2    McLachlan, R.I.3    Andersson, A.M.4
  • 3
    • 0037326103 scopus 로고    scopus 로고
    • Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study
    • Bojesen A, Juul S & Gravholt CH. (2003) Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. J Clin Endocrinol Metab 88, 622-626.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 622-626
    • Bojesen, A.1    Juul, S.2    Gravholt, C.H.3
  • 4
    • 33746449629 scopus 로고    scopus 로고
    • The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism
    • Bojesen A, Kristensen K, Birkebaek NH, Fedder J, Mosekilde L, Bennett P et al. (2006) The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism. Diabetes Care 29, 1591-1598.
    • (2006) Diabetes Care , vol.29 , pp. 1591-1598
    • Bojesen, A.1    Kristensen, K.2    Birkebaek, N.H.3    Fedder, J.4    Mosekilde, L.5    Bennett, P.6
  • 5
    • 79955472500 scopus 로고    scopus 로고
    • Bone mineral density in Klinefelter syndrome is reduced and primarily determined by muscle strength and resorptive markers, but not directly by testosterone
    • Bojesen A, Birkebæk N, Kristensen K, Heickendorff L, Mosekilde L, Christiansen JS et al. (2011a) Bone mineral density in Klinefelter syndrome is reduced and primarily determined by muscle strength and resorptive markers, but not directly by testosterone. Osteoporos Int 22, 1441-1450.
    • (2011) Osteoporos Int , vol.22 , pp. 1441-1450
    • Bojesen, A.1    Birkebæk, N.2    Kristensen, K.3    Heickendorff, L.4    Mosekilde, L.5    Christiansen, J.S.6
  • 6
    • 81455139505 scopus 로고    scopus 로고
    • Genotype and phenotype in Klinefelter syndrome - impact of androgen receptor polymorphism and skewed X inactivation
    • Bojesen A, Hertz JM & Gravholt CH. (2011b) Genotype and phenotype in Klinefelter syndrome - impact of androgen receptor polymorphism and skewed X inactivation. Int J Androl 34, e642-e648.
    • (2011) Int J Androl , vol.34
    • Bojesen, A.1    Hertz, J.M.2    Gravholt, C.H.3
  • 7
    • 79953837868 scopus 로고    scopus 로고
    • Assessment of Leydig and Sertoli cell functions in infants with nonmosaic Klinefelter syndrome: insulin-like peptide 3 levels are normal and positively correlated with LH levels
    • Cabrol S, Ross JL, Fennoy I, Bouvattier C, Roger M & Lahlou N. (2011) Assessment of Leydig and Sertoli cell functions in infants with nonmosaic Klinefelter syndrome: insulin-like peptide 3 levels are normal and positively correlated with LH levels. J Clin Endocrinol Metab 96, E746-E753.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Cabrol, S.1    Ross, J.L.2    Fennoy, I.3    Bouvattier, C.4    Roger, M.5    Lahlou, N.6
  • 8
    • 79958753138 scopus 로고    scopus 로고
    • Bone: from a reservoir of minerals to a regulator of energy metabolism
    • Confavreux CB. (2011) Bone: from a reservoir of minerals to a regulator of energy metabolism. Kidney Int 79 (Suppl. 121), S14-S19.
    • (2011) Kidney Int , vol.79 , Issue.121 SUPPL.
    • Confavreux, C.B.1
  • 9
    • 72949086887 scopus 로고    scopus 로고
    • Peripheral insulin-like factor 3 concentrations are reduced in men with type 2 diabetes mellitus: effect of glycemic control and visceral adiposity on Leydig cell function
    • Ermetici F, Donadio F, Iorio L, Malavazos AE, Dolci A, Peverelli E et al. (2009) Peripheral insulin-like factor 3 concentrations are reduced in men with type 2 diabetes mellitus: effect of glycemic control and visceral adiposity on Leydig cell function. Eur J Endocrinol 161, 853-859.
    • (2009) Eur J Endocrinol , vol.161 , pp. 853-859
    • Ermetici, F.1    Donadio, F.2    Iorio, L.3    Malavazos, A.E.4    Dolci, A.5    Peverelli, E.6
  • 10
    • 42449137005 scopus 로고    scopus 로고
    • Mutations in the insulin-like factor 3 receptor are associated with osteoporosis
    • Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Giannini S et al. (2008) Mutations in the insulin-like factor 3 receptor are associated with osteoporosis. J Bone Miner Res 23, 683-693.
    • (2008) J Bone Miner Res , vol.23 , pp. 683-693
    • Ferlin, A.1    Pepe, A.2    Gianesello, L.3    Garolla, A.4    Feng, S.5    Giannini, S.6
  • 12
    • 79953866977 scopus 로고    scopus 로고
    • Bone mass in subjects with Klinefelter syndrome: role of testosterone levels and androgen receptor gene CAG polymorphism
    • Ferlin A, Schipilliti M, Vinanzi C, Garolla A, Di Mambro A, Selice R et al. (2011b) Bone mass in subjects with Klinefelter syndrome: role of testosterone levels and androgen receptor gene CAG polymorphism. J Clin Endocrinol Metab 96, E739-E745.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Ferlin, A.1    Schipilliti, M.2    Vinanzi, C.3    Garolla, A.4    Di Mambro, A.5    Selice, R.6
  • 13
    • 79955506265 scopus 로고    scopus 로고
    • Bone density and risk of osteoporosis in Klinefelter syndrome
    • Ferlin A, Schipilliti M & Foresta C. (2011c) Bone density and risk of osteoporosis in Klinefelter syndrome. Acta Paediatr 100, 878-884.
    • (2011) Acta Paediatr , vol.100 , pp. 878-884
    • Ferlin, A.1    Schipilliti, M.2    Foresta, C.3
  • 14
    • 84882621780 scopus 로고    scopus 로고
    • Testicular function and bone metabolism-beyond testosterone
    • Ferlin A, Selice R, Carraro U & Foresta C. (2013) Testicular function and bone metabolism-beyond testosterone. Nat Rev Endocrinol 9, 548-554.
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 548-554
    • Ferlin, A.1    Selice, R.2    Carraro, U.3    Foresta, C.4
  • 17
    • 84876510688 scopus 로고    scopus 로고
    • Influence of selected exercise on serum immunoglobulin, testosterone and cortisol in semi-endurance elite runners
    • Hejazi K & Hosseini SR. (2012) Influence of selected exercise on serum immunoglobulin, testosterone and cortisol in semi-endurance elite runners. Asian J Sports Med 3, 185-192.
    • (2012) Asian J Sports Med , vol.3 , pp. 185-192
    • Hejazi, K.1    Hosseini, S.R.2
  • 18
    • 84872081636 scopus 로고    scopus 로고
    • Normal insulin-like peptide-3 levels despite low testosterone in adult males with Prader-Willi syndrome: variations in Leydig cell function from infancy through adulthood
    • Hirsch HJ, Eldar-Geva T, Gross-Tsur V, Benarroch F, Roger M & Lahlou N. (2013) Normal insulin-like peptide-3 levels despite low testosterone in adult males with Prader-Willi syndrome: variations in Leydig cell function from infancy through adulthood. J Clin Endocrinol Metab 98, E135-E143.
    • (2013) J Clin Endocrinol Metab , vol.98
    • Hirsch, H.J.1    Eldar-Geva, T.2    Gross-Tsur, V.3    Benarroch, F.4    Roger, M.5    Lahlou, N.6
  • 19
    • 79955612099 scopus 로고    scopus 로고
    • Biological role and clinical significance of insulin-like peptide 3
    • Ivell R & Anand-Ivell R. (2011) Biological role and clinical significance of insulin-like peptide 3. Curr Opin Endocrinol Diabetes Obes 18, 210-216.
    • (2011) Curr Opin Endocrinol Diabetes Obes , vol.18 , pp. 210-216
    • Ivell, R.1    Anand-Ivell, R.2
  • 20
    • 84882259830 scopus 로고    scopus 로고
    • INSL3 as a biomarker of Leydig cell functionality
    • Ivell R, Wade JD & Anand-Ivell R. (2013) INSL3 as a biomarker of Leydig cell functionality. Biol Reprod 88, 1-8.
    • (2013) Biol Reprod , vol.88 , pp. 1-8
    • Ivell, R.1    Wade, J.D.2    Anand-Ivell, R.3
  • 21
    • 84905730742 scopus 로고    scopus 로고
    • Vitamin D and male reproduction
    • Jensen MB. (2014) Vitamin D and male reproduction. Nat Rev Endocrinol 10, 175-186.
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 175-186
    • Jensen, M.B.1
  • 23
    • 84055193403 scopus 로고    scopus 로고
    • Association of hypogonadism with vitamin D status: the European Male Ageing Study
    • EMAS study group. () .
    • Lee DM, Tajar A, Pye SR, Boonen S, Vanderschueren D, Bouillon R et al.; EMAS study group. (2012) Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol 166, 77-85.
    • (2012) Eur J Endocrinol , vol.166 , pp. 77-85
    • Lee, D.M.1    Tajar, A.2    Pye, S.R.3    Boonen, S.4    Vanderschueren, D.5    Bouillon, R.6
  • 24
    • 0025542292 scopus 로고
    • Sex chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark
    • Nielsen J & Wohlert M. (1990) Sex chromosome abnormalities found among 34, 910 newborn children: results from a 13-year incidence study in Arhus, Denmark. Birth Defects Orig Artic Ser 26, 209-223.
    • (1990) Birth Defects Orig Artic Ser , vol.26 , pp. 209-223
    • Nielsen, J.1    Wohlert, M.2
  • 25
    • 34447131545 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men
    • Nielsen TL, Hagen C, Wraae K, Brixen K, Petersen PH, Haug E et al. (2007) Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men. J Clin Endocrinol Metab 92, 2696-2705.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2696-2705
    • Nielsen, T.L.1    Hagen, C.2    Wraae, K.3    Brixen, K.4    Petersen, P.H.5    Haug, E.6
  • 26
    • 79952289069 scopus 로고    scopus 로고
    • Endocrine regulation of male fertility by the skeleton
    • Oury F, Sumara G, Sumara O, Ferron M, Chang H, Smith CE et al. (2011) Endocrine regulation of male fertility by the skeleton. Cell 144, 796-809.
    • (2011) Cell , vol.144 , pp. 796-809
    • Oury, F.1    Sumara, G.2    Sumara, O.3    Ferron, M.4    Chang, H.5    Smith, C.E.6
  • 28
    • 84871925516 scopus 로고    scopus 로고
    • Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial
    • Roth MY, Lin K, Bay K, Amory JK, Anawalt BD, Matsumoto AM et al. (2013) Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial. Fertil Steril 99, 132-139.
    • (2013) Fertil Steril , vol.99 , pp. 132-139
    • Roth, M.Y.1    Lin, K.2    Bay, K.3    Amory, J.K.4    Anawalt, B.D.5    Matsumoto, A.M.6
  • 29
    • 84862744882 scopus 로고    scopus 로고
    • The endocrine role of the skeleton: background and clinical evidence
    • Schwetz V, Pieber T & Obermayer-Pietsch B. (2012) The endocrine role of the skeleton: background and clinical evidence. Eur J Endocrinol 166, 959-967.
    • (2012) Eur J Endocrinol , vol.166 , pp. 959-967
    • Schwetz, V.1    Pieber, T.2    Obermayer-Pietsch, B.3
  • 31
    • 84872327440 scopus 로고    scopus 로고
    • Pathophysiology of human visceral obesity: an update
    • Tchernof A & Després JP. (2013) Pathophysiology of human visceral obesity: an update. Physiol Rev 93, 359-404.
    • (2013) Physiol Rev , vol.93 , pp. 359-404
    • Tchernof, A.1    Després, J.P.2
  • 33
    • 84893746947 scopus 로고    scopus 로고
    • Insulin-like peptide 3 (INSL3) in men with congenital hypogonadotropic hypogonadism/Kallmann syndrome and effects of different modalities of hormonal treatment: a single-center study of 281 patients
    • Trabado S ML, Maione L, Bry-Gauillard H, Affres H, Salenave S, Sarfati J et al. (2014) Insulin-like peptide 3 (INSL3) in men with congenital hypogonadotropic hypogonadism/Kallmann syndrome and effects of different modalities of hormonal treatment: a single-center study of 281 patients. J Clin Endocrinol Metab 99, E268-E275.
    • (2014) J Clin Endocrinol Metab , vol.99
    • Trabado, S.M.1    Maione, L.2    Bry-Gauillard, H.3    Affres, H.4    Salenave, S.5    Sarfati, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.