Profiling insulin like factor 3 (INSL3) signaling in human osteoblasts

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Ferlin, Alberto ^a   Perilli, Lisa ^a   Gianesello, Lisa ^a   Taglialavoro, Giuseppe ^a   Foresta, Carlo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; G PROTEIN COUPLED RECEPTOR; INSULIN LIKE FACTOR 3; MITOGEN ACTIVATED PROTEIN KINASE; RELAXIN; RELAXIN FAMILY PEPTIDE 2; UNCLASSIFIED DRUG; ALKALINE PHOSPHATASE; INSULIN; LEYDIG INSULIN LIKE PROTEIN; LEYDIG INSULIN-LIKE PROTEIN; PROTEIN;

ARTICLE; BONE MINERALIZATION; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; OSTEOBLAST; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; METABOLISM; MOUSE; PHOSPHORYLATION;

MUS;

ALKALINE PHOSPHATASE; ANIMALS; BLOTTING, WESTERN; CALCIUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMANS; INSULIN; MICE; OSTEOBLASTS; PHOSPHORYLATION; PROTEINS; SIGNAL TRANSDUCTION;

EID: 84555203650     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029733     Document Type: Article

References (44)

1. Clarke BL, Khosla S, (2009) Androgens and bone. Steroids 74: 296-305.
2. Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, et al. (2004) Androgen and bone. Endocr Rev 5: 389-425.
3. Foresta C, Bettella A, Vinanzi C, Dabrilli P, Meriggiola MC, et al. (2004) Insulin like factor 3: A novel circulating hormone of testis origin in humans. J Clin Endocrinol Metab 89: 5952-5958.
4. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, et al. (2008) Mutations in the insulin-like factor 3 receptor are associated with osteoporosis. J Bone Miner Res 23: 683-693.
5. Pepe A, Ferlin A, Gianesello L, Facciolli A, Agoulnik AI, et al. (2009) INSL3 plays a role in the balance between bone formation and resorption. Ann N Y Acad Sci 1160: 219-220.
6. Feng S, Ferlin A, Truong A, Bathgate R, Wade JD, et al. (2009) INSL3/RXFP2 signaling in testicular descent. Ann N Y Acad Sci 1160: 197-204.
7. Agoulnik AI, (2007) Relaxin and related peptides in male reproduction. Adv Exp Med Biol 612: 49-64.
8. Ferlin A, Garolla A, Rigon F, Rasi Caldogno L, Lenzi A, et al. (2006) Changes in serum Insulin-like factor 3 (INSL3) during normal male puberty. J Clin Endocrinol Metab 91: 3426-3431.
9. Bay K, Matthiesson KL, McLachlan RI, Andersson AM, (2006) The effects of gonadotropin suppression and selective replacement on insulin-like factor 3 secretion in normal adult men. J Clin Endocrinol Metab 91: 1108-1111.
10. Sadeghian H, Anand-Ivell R, Balvers M, Relan V, Ivell R, (2005) Constitutive regulation of the Insl3 gene in rat Leydig cells. Mol Cell Endocrinol 241: 10-20.
11. Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, et al. (2009) New roles for INSL3 in adults. Ann N Y Acad Sci 1160: 215-218.
12. Kaftanovskaya EM, Feng S, Huang Z, Tan Y, Barbara AM, et al. (2011) Suppression of Insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development. Mol Endocrinol 25: 170-183.
13. Zaidi M, (2007) Skeletal Remodeling in health and disease. Nat Med 13: 791-801.
14. Echeverria V, Burgess S, Gamble-George J, Arendash GW, Citron BA, (2008) Raf inhibition protects cortical cells against beta-amyloid toxicity. Neurosci Lett 444: 92-96.
15. Fukami K, Inanobe S, Kanemaru K, Nakamura Y, (2010) Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance. Prog Lipid Res 49: 429-437.
16. Schulte G, Fredholm BB, (2003) Signalling from adenosine receptors to mitogen-activated protein kinases. Cell Signal 15: 813-827.
17. Beaulieu JM, Gainetdinov RR, Caron MG, (2007) The Akt-GSK-3 signaling cascade in the actions of dopamine. Trends Pharmacol Sci 28: 166-172.
18. Gehart H, Kumpf S, Ittner A, Ricci R, (2010) MAPK signalling in cellular metabolism: stress or wellness? EMBO Rep 11: 834-840.
19. Chau JF, Leong WF, Li B, (2009) Signaling pathways governing osteoblast proliferation, differentiation and function. Histol Histopathol 24: 1593-1606.
20. Raucci A, Bellosta P, Grassi R, Basilico C, Mansukhani A, (2008) Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways. J Cell Physiol 215: 442-451.
21. Zhang B, Li S, Harbrecht BG, (2011) Akt-mediated signaling is induced by cytokines and cyclic adenosine monophosphate and suppresses hepatocyte inducible nitric oxide synthase expression independent of MAPK P44/42. Biochim Biophys Acta 1813: 73-79.
22. Franke TF, (2008) Intracellular signaling by Akt: bound to be specific. Sci Signal 1: pe29.
23. Doble BW, Woodgett JR, (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116: 1175-1186.
24. Rockel JS, Grol M, Bernier SM, Leask A, (2009) Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes. Matrix Biol 28: 354-364.
25. Gustin JA, Korgaonkar CK, Pincheira R, Li Q, Donner DB, (2006) Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52. J Biol Chem 281: 16473-16481.
26. Buss H, Dörrie A, Schmitz ML, Frank R, Livingstone M, et al. (2004) Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J Biol Chem 279: 49571-49574.
27. Liu R, Lioté F, Rose DM, Merz D, Terkeltaub R, (2004) Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Arthritis Rheum 50: 247-258.
28. Shahrara S, Castro-Rueda HP, Haines GK, Koch AE, (2007) Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues. Arthritis Res Ther 9: R112.
29. Milat F, Ng KW, (2009) Is Wnt signalling the final common pathway leading to bone formation? Mol Cell Endocrinol 310: 52-62.
30. Verheyen EM, Gottardi CJ, (2010) Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn 239: 34-44.
31. Komori T, (2010) Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell Tissue Res 339: 189-195.
32. Bailey AJ, Wotton SF, Sims TJ, Thompson PW, (1993) Biochemical changes in the collagen of human osteoporotic bone matrix. Connect Tissue Res 29: 119-132.
33. Lian JB, Stein GS, (1995) Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation. Iowa Orthop J 15: 118-140.
34. Termine JD, (1990) Cellular activity, matrix proteins, and aging bone. Exp Gerontol 25: 217-221.
35. Haylock DN, Nilsson SK, (2006) Osteopontin: a bridge between bone and blood. Br J Haematol 134: 467-474.
36. Gómez-Ambrosi J, Rodríguez A, Catalán V, Frühbeck G, (2008) The bone-adipose axis in obesity and weight loss. Obes Surg 18: 1134-1143.
37. Robey PG, Young MF, Flanders KC, Roche NS, Kondaiah P, et al. (1987) Osteoblasts synthesize and respond to transforming growth factortype b (TGF-b) in vitro. J Cell Biol 105: 457-463.
38. Zhang H, Aronow MS, Gronowicz GA, (2005) Transforming growth factor-beta 1 (TGF-beta1) prevents the age-dependent decrease in bone formation in human osteoblast/implant cultures. J Biomed Mater Res A 75: 98-105.
39. Simonet WS, Lacey DL, Dunstan C, Kelly M, Chang MS, et al. (1997) Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89: 309-319.
40. Notelovitz M, (2002) Androgen effects on bone and muscle. Fertil Steril 77: S34-41.
41. St-Arnaud R, (2008) The direct role of vitamin D on bone homeostasis. Arch Biochem Biophys 473: 225-230.
42. Barrett MG, Belinsky GS, Tashjian AH Jr, (1997) A new action of parathyroid hormone. receptor-mediated stimulation of extracellular acidification in human osteoblast-like SaOS-2 cells. J Biol Chem 272: 26346-26353.
43. Velasco J, Zarrabeitia MT, Prieto JR, Perez-Castrillón JL, Perez-Aguilar MD, et al. (2010) Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study. Osteoporos Int 21: 109-118.
44. Bogatcheva NV, Ferlin A, Feng S, Truong A, Gianesello L, et al. (2007) T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane. Am J Physiol Endocrinol Metab 292: E138-144.