Factors that contribute to hypertransaminasemia in patients with celiac disease or functional gastrointestinal syndromes

Clinical Gastroenterology and Hepatology

Volumn 12, Issue 5, 2014, Pages 804-810.e2

  Zanini, Barbara ^a   Baschè, Roberta ^a   Ferraresi, Alice ^a   Pigozzi, Marie Graciella ^a   Ricci, Chiara ^a   Lanzarotto, Francesco ^a   Villanacci, Vincenzo ^a   Lanzini, Alberto ^a  

^a SPEDALI CIVILI   (Italy)

Author keywords

Associated Diseases; Clinical Presentation; Gluten Allergy; Liver

Indexed keywords

ASPARTATE AMINOTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; AMINOTRANSFERASE;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BODY MASS; CELIAC DISEASE; CONTROLLED STUDY; DIARRHEA; DIGESTIVE SYSTEM FUNCTION DISORDER; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GLUTEN FREE DIET; HISTOLOGY; HUMAN; HYPERTRANSAMINASEMIA; MAJOR CLINICAL STUDY; MALABSORPTION; MALE; BLOOD; DUODENUM; ENTERITIS; ITALY; MIDDLE AGED; PATHOLOGY;

ADULT; CELIAC DISEASE; DUODENUM; ENTERITIS; FEMALE; HUMANS; ITALY; MALE; MIDDLE AGED; TRANSAMINASES;

EID: 84899091893     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.10.033     Document Type: Article

References (23)

1. Rubio-Tapia A., Murray J.A. The liver in celiac disease. Hepatology 2007, 46:1650-1658.
2. Sainsbury A., Sanders D.S., Ford A.C. Meta-analysis: coeliac disease and hypertransaminasemia. Aliment Pharmacol Ther 2011, 34:33-40.
3. Korpimaki S., Kaukinen K., Collin P., et al. Gluten-sensitive hypertransaminasemia in celiac disease: an infrequent and often subclinical finding. Am J Gastroenterol 2011, 106:1689-1696.
4. Bardella M.T., Fraquelli M., Quatrini M., et al. Prevalence of hypertransaminasemia in adult celiac patients and effect of gluten-free diet. Hepatology 1995, 22:833-836.
5. Novacek G., Miehsler W., Wrba F., et al. Prevalence and clinical importance of hypertransaminasemia in coeliac disease. Eur J Gastroenterol Hepatol 1999, 11:283-288.
6. Foley A., Sheperd S.J., Gibson P.R. Frequency of elevated ALT in untreated coeliac disease and the impact of compliance with gluten free diet on ALT normalisation. Gastroenterology 2010, 138:S-309.
7. Lewis N.R., Sanders D.S., Teahon K., et al. Prevalence and consequence of hypertransaminasemia in incident coeliac disease: how common is it and does it matter?. Gut 2009, 58:A6.
8. Dickey W., McMillan S.A., Collins J.S., et al. Liver abnormalities associated with celiac sprue. How common are they, what is their significance, and what do we do about them?. JClin Gastroenterol 1995, 20:290-292.
9. Lanzini A., Lanzarotto F., Villanacci V., et al. Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet. Aliment Pharmacol Ther 2009, 29:1299-1308.
10. Oberhuber G., Granditsch G., Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999, 11:1185-1194.
11. Ruhl C.E., Everhart J.E. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003, 124:71-79.
12. Pendino G.M., Mariano A., Surace P., et al. Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town. Hepatology 2005, 41:1151-1159.
13. Kabbani T.A., Goldberg A., Kelly C.P., et al. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther 2012, 35:723-729.
14. West J., Logan R.F., Hill P.G., et al. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 2003, 52:960-965.
15. Zanini B., Mazzoncini E., Lanzarotto F., et al. Impact of gluten-free diet on cardiovascular risk factors. A retrospective analysis in a large cohort of coeliac patients. Dig Liver Dis 2013, 45:810-815.
16. Etukudo M.H., Agbedana E.O., Akinyinka O.O., et al. Plasma electrolytes, total cholesterol, liver enzymes, and selected antioxidant status in protein energy malnutrition. Afr J Med Med Sci 1999, 28:81-85.
17. Hanachi M., Melchior J.C., Crenn P. Hypertransaminasemia in severely malnourished adult anorexia nervosa patients: risk factors and evolution under enteral nutrition. Clin Nutr 2013, 32:391-395.
18. Smecuol E., Bai J.C., Vazquez H., et al. Gastrointestinal permeabilityin celiac disease. Gastroenterology 1997, 112:1129-1136.
19. Pelaez-Luna M., Schmulson M., Robles-Diaz G. Intestinal involvement is not sufficient to explain hypertransaminasemia in celiac disease?. Med Hypotheses 2005, 65:937-941.
20. Aeschlimann D., Paulsson M. Cross-linking of laminin-nidogen complexes by tissue transglutaminase. A novel mechanism for basement membrane stabilization. JBiol Chem 1991, 266:15308-15317.
21. Korponay-Szabo I.R., Halttunen T., Szalai Z., et al. Invivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies. Gut 2004, 53:641-648.
22. Hadjivassiliou M., Maki M., Sanders D.S., et al. Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia. Neurology 2006, 66:373-377.
23. Prati D., Taioli E., Zanella A., et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002, 137:1-10.