메뉴 건너뛰기




Volumn 13, Issue 5, 2014, Pages 535-549

Targeting the epidermal growth factor receptor in solid tumors: Focus on safety

Author keywords

Adverse events; EGFR; Management strategies; Monoclonal antibodies; Skin rash; Tyrosine kinase inhibitors

Indexed keywords

AFATINIB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; LAPATINIB; PANITUMUMAB; SORAFENIB; SUNITINIB; VANDETANIB; ANTINEOPLASTIC AGENT;

EID: 84899090908     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2014.904283     Document Type: Review
Times cited : (35)

References (76)
  • 1
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003;21(14):2787-99
    • (2003) J Clin Oncol , vol.21 , Issue.14 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 2
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008;358(11):1160-74
    • (2008) N Engl J Med , vol.358 , Issue.11 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 3
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type kras is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al. Wild-type kras is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008;26(10):1626-34
    • (2008) J Clin Oncol , vol.26 , Issue.10 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 4
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009;27(5):663-71
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 5
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006;368(9544):1329- 38
    • (2006) Lancet , vol.368 , Issue.9544 , pp. 1329-1338
    • Demetri, G.D.1    Van Oosterom, A.T.2    Garrett, C.R.3
  • 6
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356(2):125-34
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 7
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for her2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for her2-positive advanced breast cancer. N Engl J Med 2006;355(26):2733-43
    • (2006) N Engl J Med , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 8
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen J Jr, Pivot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27(33):5538-46
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5538-5546
    • Johnston, S.1    Pippen Jr., J.2    Pivot, X.3
  • 9
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359(17):1757-65
    • (2008) N Engl J Med , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 10
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359(4):378-90
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 11
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362(25):2380-8
    • (2010) N Engl J Med , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 12
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11(2):121-8
    • (2010) Lancet Oncol , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 13
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361(10):947-57
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 14
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase iii trial of the national cancer institute of canada clinical trials group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase iii trial of the national cancer institute of canada clinical trials group. J Clin Oncol 2007;25(15):1960-6
    • (2007) J Clin Oncol , vol.25 , Issue.15 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 15
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356(2):115-24
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 16
    • 79851482955 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
    • Raymond E, Dahan L, Raoul JL, et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 2011;364(6):501-13
    • (2011) N Engl J Med , vol.364 , Issue.6 , pp. 501-513
    • Raymond, E.1    Dahan, L.2    Raoul, J.L.3
  • 17
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for european patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre open-label randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for european patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13(3):239-46
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 18
    • 84884736973 scopus 로고    scopus 로고
    • Phase iii study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV, Yang JC, Yamamoto N, et al. Phase iii study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013;31(27):3327-34
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 19
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353(2):123-32
    • (2005) N Engl J Med , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 20
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009;360(14):1408-17
    • (2009) N Engl J Med , vol.360 , Issue.14 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 21
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008;359(11):1116-27
    • (2008) N Engl J Med , vol.359 , Issue.11 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 22
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase iii trial
    • Wells SA Jr, Robinson BG, Gagel RF, et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase iii trial. J Clin Oncol 2012;30(2):134-41
    • (2012) J Clin Oncol , vol.30 , Issue.2 , pp. 134-141
    • Wells Jr., S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 23
    • 80051528496 scopus 로고    scopus 로고
    • Necitumumab in the treatment of advanced non-small cell lung cancer: Translation from preclinical to clinical development
    • Dienstmann R, Felip E. Necitumumab in the treatment of advanced non-small cell lung cancer: translation from preclinical to clinical development. Expert Opin Biol Ther 2011;11(9):1223-31
    • (2011) Expert Opin Biol Ther , vol.11 , Issue.9 , pp. 1223-1231
    • Dienstmann, R.1    Felip, E.2
  • 24
    • 84893600097 scopus 로고    scopus 로고
    • Nimotuzumab combined with radiotherapy for esophageal cancer: Preliminary study of a phase ii clinical trial
    • Liang J, E M, Wu G, et al. Nimotuzumab combined with radiotherapy for esophageal cancer: preliminary study of a phase ii clinical trial. Onco Targets Ther 2013;6:1589-96
    • (2013) Onco Targets Ther , vol.6 , pp. 1589-1596
    • Liang, J.E.M.1    Wu, G.2
  • 25
    • 84883050731 scopus 로고    scopus 로고
    • Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): A randomised double-blind phase 3 non-inferiority trial
    • Shi Y, Zhang L, Liu X, et al. Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial. Lancet Oncol 2013;14(10):953-61
    • (2013) Lancet Oncol , vol.14 , Issue.10 , pp. 953-961
    • Shi, Y.1    Zhang, L.2    Liu, X.3
  • 26
    • 84984568870 scopus 로고    scopus 로고
    • Clinical practice guidelines for the prevention and treatment of egfr inhibitor-associated dermatologic toxicities
    • Group MSTS
    • Lacouture ME, Anadkat MJ, Bensadoun RJ, Group MSTS. Clinical practice guidelines for the prevention and treatment of egfr inhibitor-associated dermatologic toxicities. Support Care Cancer 2011;19(8):1079-95
    • (2011) Support Care Cancer , vol.19 , Issue.8 , pp. 1079-1095
    • Lacouture, M.E.1    Anadkat, M.J.2    Bensadoun, R.J.3
  • 27
    • 84861199721 scopus 로고    scopus 로고
    • Recommendations on management of egfr inhibitor-induced skin toxicity: A systematic review
    • Baas JM, Krens LL, Guchelaar HJ, et al. Recommendations on management of egfr inhibitor-induced skin toxicity: a systematic review. Cancer Treat Rev 2012;38(5):505-14
    • (2012) Cancer Treat Rev , vol.38 , Issue.5 , pp. 505-514
    • Baas, J.M.1    Krens, L.L.2    Guchelaar, H.J.3
  • 28
    • 77950495095 scopus 로고    scopus 로고
    • Skin toxicity evaluation protocol with panitumumab (STEPP), a phase ii, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer
    • Lacouture ME, Mitchell EP, Piperdi B, et al. Skin toxicity evaluation protocol with panitumumab (STEPP), a phase ii, open-label, randomized trial evaluating the impact of a pre-emptive skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancer. J Clin Oncol 2010;28(8):1351-7
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1351-1357
    • Lacouture, M.E.1    Mitchell, E.P.2    Piperdi, B.3
  • 29
    • 33748935930 scopus 로고    scopus 로고
    • Dermatologic side effects associated with the epidermal growth factor receptor inhibitors
    • Agero AL, Dusza SW, Benvenuto-Andrade C, et al. Dermatologic side effects associated with the epidermal growth factor receptor inhibitors. J Am Acad Dermatol 2006;55(4):657-70
    • (2006) J Am Acad Dermatol , vol.55 , Issue.4 , pp. 657-670
    • Agero, A.L.1    Dusza, S.W.2    Benvenuto-Andrade, C.3
  • 30
    • 33749018219 scopus 로고    scopus 로고
    • Mechanisms of cutaneous toxicities to EGFR inhibitors
    • Lacouture ME. Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat Rev Cancer 2006;6(10):803-12
    • (2006) Nat Rev Cancer , vol.6 , Issue.10 , pp. 803-812
    • Lacouture, M.E.1
  • 31
    • 79952601240 scopus 로고    scopus 로고
    • Management of skin toxicity associated with cetuximab treatment in combination with chemotherapy or radiotherapy
    • American Society of Clinical Oncology; European Society of Medical Oncology
    • Pinto C, Barone CA, Girolomoni G, American Society of Clinical Oncology; European Society of Medical Oncology. Management of skin toxicity associated with cetuximab treatment in combination with chemotherapy or radiotherapy. Oncologist 2011;16(2):228-38
    • (2011) Oncologist , vol.16 , Issue.2 , pp. 228-238
    • Pinto, C.1    Barone, C.A.2    Girolomoni, G.3
  • 32
    • 0029664491 scopus 로고    scopus 로고
    • Assessment of quality-of-life outcomes
    • Testa MA, Simonson DC. Assessment of quality-of-life outcomes. N Engl J Med 1996;334(13):835-40
    • (1996) N Engl J Med , vol.334 , Issue.13 , pp. 835-840
    • Testa, M.A.1    Simonson, D.C.2
  • 33
    • 33847643669 scopus 로고    scopus 로고
    • Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors
    • Galimont-Collen AF, Vos LE, Lavrijsen AP, et al. Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors. Eur J Cancer 2007;43(5):845-51
    • (2007) Eur J Cancer , vol.43 , Issue.5 , pp. 845-851
    • Galimont-Collen, A.F.1    Vos, L.E.2    Lavrijsen, A.P.3
  • 34
    • 33846245846 scopus 로고    scopus 로고
    • Cutaneous side effects of epidermal growth factor receptor inhibitors: Clinical presentation, pathogenesis, and management
    • Hu JC, Sadeghi P, Pinter-Brown LC, et al. Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management. J Am Acad Dermatol 2007;56(2):317-26
    • (2007) J Am Acad Dermatol , vol.56 , Issue.2 , pp. 317-326
    • Hu, J.C.1    Sadeghi, P.2    Pinter-Brown, L.C.3
  • 35
    • 84882889101 scopus 로고    scopus 로고
    • Erlotinib-related skin toxicities: Treatment strategies in patients with metastatic nonsmall cell lung cancer
    • Kiyohara Y, Yamazaki N, Kishi A. Erlotinib-related skin toxicities: treatment strategies in patients with metastatic nonsmall cell lung cancer. J Am Acad Dermatol 2013;69(3):463-72
    • (2013) J Am Acad Dermatol , vol.69 , Issue.3 , pp. 463-472
    • Kiyohara, Y.1    Yamazaki, N.2    Kishi, A.3
  • 36
    • 63449110924 scopus 로고    scopus 로고
    • Increased risk of high-grade dermatologic toxicities with radiation plus epidermal growth factor receptor inhibitor therapy
    • Tejwani A, Wu S, Jia Y, et al. Increased risk of high-grade dermatologic toxicities with radiation plus epidermal growth factor receptor inhibitor therapy. Cancer 2009;115(6):1286-99
    • (2009) Cancer , vol.115 , Issue.6 , pp. 1286-1299
    • Tejwani, A.1    Wu, S.2    Jia, Y.3
  • 37
    • 84870186697 scopus 로고    scopus 로고
    • The effect of hand-foot skin reaction associated with the multikinase inhibitors sorafenib and sunitinib on health-related quality of life
    • Nardone B, Hensley JR, Kulik L, et al. The effect of hand-foot skin reaction associated with the multikinase inhibitors sorafenib and sunitinib on health-related quality of life. J Drugs Dermatol 2012;11(11):e61-5
    • (2012) J Drugs Dermatol , vol.11 , Issue.11
    • Nardone, B.1    Hensley, J.R.2    Kulik, L.3
  • 38
    • 84891943861 scopus 로고    scopus 로고
    • Angiogenesis inhibitor therapies for advanced renal cell carcinoma: Toxicity and treatment patterns in clinical practice from a global medical chart review
    • Oh WK, McDermott D, Porta C, et al. Angiogenesis inhibitor therapies for advanced renal cell carcinoma: toxicity and treatment patterns in clinical practice from a global medical chart review. Int J Oncol 2014;44(1):5-16
    • (2014) Int J Oncol , vol.44 , Issue.1 , pp. 5-16
    • Oh, W.K.1    McDermott, D.2    Porta, C.3
  • 39
    • 84879347777 scopus 로고    scopus 로고
    • Diarrhea associated with afatinib: An oral ErbB family blocker
    • Yang JC, Reguart N, Barinoff J, et al. Diarrhea associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther 2013;13(6):729-36
    • (2013) Expert Rev Anticancer Ther , vol.13 , Issue.6 , pp. 729-736
    • Yang, J.C.1    Reguart, N.2    Barinoff, J.3
  • 40
    • 79952927826 scopus 로고    scopus 로고
    • Adverse events associated with anti-EGFR therapies for the treatment of metastatic colorectal cancer
    • Fakih M, Vincent M. Adverse events associated with anti-EGFR therapies for the treatment of metastatic colorectal cancer. Curr Oncol 2010;17(Suppl 1):S18-30
    • (2010) Curr Oncol , vol.17 , Issue.SUPPL. 1
    • Fakih, M.1    Vincent, M.2
  • 41
    • 79959295780 scopus 로고    scopus 로고
    • Managing treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced non-small-cell lung cancer
    • Hirsh V. Managing treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced non-small-cell lung cancer. Curr Oncol 2011;18(3):126-38
    • (2011) Curr Oncol , vol.18 , Issue.3 , pp. 126-138
    • Hirsh, V.1
  • 42
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase iii trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero AF, Maurel J, Fehrenbacher L, et al. EPIC: phase iii trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008;26(14):2311-19
    • (2008) J Clin Oncol , vol.26 , Issue.14 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 43
    • 34548289390 scopus 로고    scopus 로고
    • FDA drug approval summary: Panitumumab (vectibix
    • Giusti RM, Shastri KA, Cohen MH, et al. FDA drug approval summary: panitumumab (vectibix). Oncologist 2007;12(5):577-83
    • (2007) Oncologist , vol.12 , Issue.5 , pp. 577-583
    • Giusti, R.M.1    Shastri, K.A.2    Cohen, M.H.3
  • 44
    • 84901290217 scopus 로고    scopus 로고
    • FDA drug approval summary: Lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses her-2
    • Ryan Q, Ibrahim A, Cohen MH, et al. FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses her-2. Oncologist 2008;13(10):1114-19
    • (2008) Oncologist , vol.13 , Issue.10 , pp. 1114-1119
    • Ryan, Q.1    Ibrahim, A.2    Cohen, M.H.3
  • 45
    • 84866599720 scopus 로고    scopus 로고
    • Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO clinical practice guidelines
    • Group EGW
    • Curigliano G, Cardinale D, Suter T, Group EGW. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO clinical practice guidelines. Ann Oncol 2012;23(Suppl 7):vii155-66
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 7
    • Curigliano, G.1    Cardinale, D.2    Suter, T.3
  • 46
    • 84883021976 scopus 로고    scopus 로고
    • Cardiovascular toxicity of tyrosine kinase inhibitors
    • Mouhayar E, Durand JB, Cortes J. Cardiovascular toxicity of tyrosine kinase inhibitors. Expert Opin Drug Saf 2013;12(5):687-96
    • (2013) Expert Opin Drug Saf , vol.12 , Issue.5 , pp. 687-696
    • Mouhayar, E.1    Durand, J.B.2    Cortes, J.3
  • 47
    • 84863041902 scopus 로고    scopus 로고
    • Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors
    • Steingart RM, Bakris GL, Chen HX, et al. Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors. Am Heart J 2012;163(2):156-63
    • (2012) Am Heart J , vol.163 , Issue.2 , pp. 156-163
    • Steingart, R.M.1    Bakris, G.L.2    Chen, H.X.3
  • 48
    • 0031943236 scopus 로고    scopus 로고
    • Vegf upregulates ecnos message, protein, and no production in human endothelial cells
    • Hood JD, Meininger CJ, Ziche M, Granger HJ. Vegf upregulates ecnos message, protein, and no production in human endothelial cells. Am J Physiol 1998;274(3 Pt 2):H1054-8
    • (1998) Am J Physiol , vol.274 , Issue.3 PART 2
    • Hood, J.D.1    Meininger, C.J.2    Ziche, M.3    Granger, H.J.4
  • 49
    • 77949400086 scopus 로고    scopus 로고
    • Reduction in skin microvascular density and changes in vessel morphology in patients treated with sunitinib
    • van der Veldt AA, de Boer MP, Boven E, et al. Reduction in skin microvascular density and changes in vessel morphology in patients treated with sunitinib. Anticancer Drugs 2010;21(4):439-46
    • (2010) Anticancer Drugs , vol.21 , Issue.4 , pp. 439-446
    • Van Der Veldt, A.A.1    De Boer, M.P.2    Boven, E.3
  • 51
    • 36849023013 scopus 로고    scopus 로고
    • Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
    • Chu TF, Rupnick MA, Kerkela R, et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 2007;370(9604):2011-19
    • (2007) Lancet , vol.370 , Issue.9604 , pp. 2011-2019
    • Chu, T.F.1    Rupnick, M.A.2    Kerkela, R.3
  • 52
    • 84877769909 scopus 로고    scopus 로고
    • Cardiovascular safety of tyrosine kinase inhibitors: With a special focus on cardiac repolarisation (QT interval)
    • Shah RR, Morganroth J, Shah DR. Cardiovascular safety of tyrosine kinase inhibitors: with a special focus on cardiac repolarisation (QT interval). Drug Saf 2013;36(5):295-316
    • (2013) Drug Saf , vol.36 , Issue.5 , pp. 295-316
    • Shah, R.R.1    Morganroth, J.2    Shah, D.R.3
  • 53
    • 77954724869 scopus 로고    scopus 로고
    • Cardiovascular effects of EGFR (epidermal growth factor receptor) monoclonal antibodies
    • Chaudhary P, Gajra A. Cardiovascular effects of EGFR (epidermal growth factor receptor) monoclonal antibodies. Cardiovasc Hematol Agents Med Chem 2010;8(3):156-63
    • (2010) Cardiovasc Hematol Agents Med Chem , vol.8 , Issue.3 , pp. 156-163
    • Chaudhary, P.1    Gajra, A.2
  • 54
    • 84864322826 scopus 로고    scopus 로고
    • Risk of venous and arterial thromboembolic events associated with anti-EGFR agents: A meta-analysis of randomized clinical trials
    • Petrelli F, Cabiddu M, Borgonovo K, Barni S. Risk of venous and arterial thromboembolic events associated with anti-EGFR agents: a meta-analysis of randomized clinical trials. Ann Oncol 2012;23(7):1672-9
    • (2012) Ann Oncol , vol.23 , Issue.7 , pp. 1672-1679
    • Petrelli, F.1    Cabiddu, M.2    Borgonovo, K.3    Barni, S.4
  • 55
    • 0043210670 scopus 로고    scopus 로고
    • FDA drug approval summary: Gefitinib (ZD1839) (Iressa) tablets
    • Cohen MH, Williams GA, Sridhara R, et al. FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets. Oncologist 2003;8(4):303-6
    • (2003) Oncologist , vol.8 , Issue.4 , pp. 303-306
    • Cohen, M.H.1    Williams, G.A.2    Sridhara, R.3
  • 56
    • 34548509696 scopus 로고    scopus 로고
    • Fatal interstitial lung disease associated with oral erlotinib therapy for lung cancer
    • Makris D, Scherpereel A, Copin MC, et al. Fatal interstitial lung disease associated with oral erlotinib therapy for lung cancer. BMC Cancer 2007;7:150
    • (2007) BMC Cancer , vol.7 , pp. 150
    • Makris, D.1    Scherpereel, A.2    Copin, M.C.3
  • 57
    • 84899077902 scopus 로고    scopus 로고
    • A case of fatal cetuximab-induced interstitial lung disease during the first weeks of treatment
    • [Epub ahead of print]
    • Shablak A, Conn A. A case of fatal cetuximab-induced interstitial lung disease during the first weeks of treatment. Target Oncol 2013. [Epub ahead of print]
    • (2013) Target Oncol
    • Shablak, A.1    Conn, A.2
  • 58
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker DJ, OCallaghan CJ, Karapetis CS, et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007;357(20):2040-8
    • (2007) N Engl J Med , vol.357 , Issue.20 , pp. 2040-2048
    • Jonker, D.J.1    Ocallaghan, C.J.2    Karapetis, C.S.3
  • 59
    • 2142641698 scopus 로고    scopus 로고
    • Phase ii trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ Sr, et al. Phase ii trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004;22(7):1201-8
    • (2004) J Clin Oncol , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3
  • 60
    • 79151468802 scopus 로고    scopus 로고
    • Monte carlo simulations of plasma membrane corral-induced EGFR clustering
    • Costa MN, Radhakrishnan K, Edwards JS. Monte carlo simulations of plasma membrane corral-induced EGFR clustering. J Biotechnol 2011;151(3):261-70
    • (2011) J Biotechnol , vol.151 , Issue.3 , pp. 261-270
    • Costa, M.N.1    Radhakrishnan, K.2    Edwards, J.S.3
  • 61
    • 84875608267 scopus 로고    scopus 로고
    • Association of hypomagnesemia with inferior survival in a phase iii randomized study of cetuximab plus best supportive care versus best supportive care alone: NCIC CTG/AGITG CO.17
    • Vickers MM, Karapetis CS, Tu D, et al. Association of hypomagnesemia with inferior survival in a phase iii, randomized study of cetuximab plus best supportive care versus best supportive care alone: NCIC CTG/AGITG CO.17. Ann Oncol 2013;24(4):953-60
    • (2013) Ann Oncol , vol.24 , Issue.4 , pp. 953-960
    • Vickers, M.M.1    Karapetis, C.S.2    Tu, D.3
  • 62
    • 33947504732 scopus 로고    scopus 로고
    • Phase ii clinical trial of chemotherapy-naive patients or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer
    • Jackman DM, Yeap BY, Lindeman NI, et al. Phase ii clinical trial of chemotherapy-naive patients or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer. J Clin Oncol 2007;25(7):760-6
    • (2007) J Clin Oncol , vol.25 , Issue.7 , pp. 760-766
    • Jackman, D.M.1    Yeap, B.Y.2    Lindeman, N.I.3
  • 63
    • 4344646459 scopus 로고    scopus 로고
    • Determinants of tumor response and survival with erlotinib in patients with non - Small-cell lung cancer
    • Perez-Soler R, Chachoua A, Hammond LA, et al. Determinants of tumor response and survival with erlotinib in patients with non - small-cell lung cancer. J Clin Oncol 2004;22(16):3238-47
    • (2004) J Clin Oncol , vol.22 , Issue.16 , pp. 3238-3247
    • Perez-Soler, R.1    Chachoua, A.2    Hammond, L.A.3
  • 64
    • 33646381931 scopus 로고    scopus 로고
    • Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest oncology group study s0126
    • West HL, Franklin WA, McCoy J, et al. Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest oncology group study s0126. J Clin Oncol 2006;24(12):1807-13
    • (2006) J Clin Oncol , vol.24 , Issue.12 , pp. 1807-1813
    • West, H.L.1    Franklin, W.A.2    McCoy, J.3
  • 65
    • 33144461661 scopus 로고    scopus 로고
    • Phase iii randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An eastern cooperative oncology group study
    • Eastern Cooperative Oncology Group
    • Burtness B, Goldwasser MA, Flood W, Eastern Cooperative Oncology Group. Phase iii randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an eastern cooperative oncology group study. J Clin Oncol 2005;23(34):8646-54
    • (2005) J Clin Oncol , vol.23 , Issue.34 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3
  • 66
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer. N Engl J Med 2004;351(4):337-45
    • (2004) N Engl J Med , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 67
    • 33750615769 scopus 로고    scopus 로고
    • Multicenter phase ii and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
    • Lenz HJ, Van Cutsem E, Khambata-Ford S, et al. Multicenter phase ii and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J Clin Oncol 2006;24(30):4914-21
    • (2006) J Clin Oncol , vol.24 , Issue.30 , pp. 4914-4921
    • Lenz, H.J.1    Van Cutsem, E.2    Khambata-Ford, S.3
  • 68
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase iii trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
    • Van Cutsem E Peeters M, et al. Open-label phase iii trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007;25(13):1658-64
    • (2007) J Clin Oncol , vol.25 , Issue.13 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2
  • 69
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A, Bachet JB, Boige V, et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008;26(3) 374-9.
    • (2008) J Clin Oncol , vol.26 , Issue.3 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3
  • 70
    • 65549150854 scopus 로고    scopus 로고
    • Phase iii trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • Van Cutsem E, Vervenne WL, Bennouna J, et al. Phase iii trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009;27(13):2231-7
    • (2009) J Clin Oncol , vol.27 , Issue.13 , pp. 2231-2237
    • Van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 71
    • 84880830066 scopus 로고    scopus 로고
    • First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer
    • Vaccaro V, Bria E, Sperduti I, et al. First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer. World J Gastroenterol 2013;19(28):4511-19
    • (2013) World J Gastroenterol , vol.19 , Issue.28 , pp. 4511-4519
    • Vaccaro, V.1    Bria, E.2    Sperduti, I.3
  • 72
    • 84866144502 scopus 로고    scopus 로고
    • Relationship between skin rash and outcome in non-small-cell lung cancer patients treated with anti-egfr tyrosine kinase inhibitors: A literature-based metaanalysis of 24 trials
    • Petrelli F, Borgonovo K, Cabiddu M, et al. Relationship between skin rash and outcome in non-small-cell lung cancer patients treated with anti-egfr tyrosine kinase inhibitors: a literature-based metaanalysis of 24 trials. Lung Cancer 2012;78(1):8-15
    • (2012) Lung Cancer , vol.78 , Issue.1 , pp. 8-15
    • Petrelli, F.1    Borgonovo, K.2    Cabiddu, M.3
  • 73
    • 79955767772 scopus 로고    scopus 로고
    • Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
    • Rini BI, Cohen DP, Lu DR, et al. Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2011;103(9):763-73
    • (2011) J Natl Cancer Inst , vol.103 , Issue.9 , pp. 763-773
    • Rini, B.I.1    Cohen, D.P.2    Lu, D.R.3
  • 74
    • 84869820857 scopus 로고    scopus 로고
    • Hypertension as a potential biomarker of efficacy in patients with gastrointestinal stromal tumor treated with sunitinib
    • George S, Reichardt P, Lechner T, et al. Hypertension as a potential biomarker of efficacy in patients with gastrointestinal stromal tumor treated with sunitinib. Ann Oncol 2012;23(12):3180-7
    • (2012) Ann Oncol , vol.23 , Issue.12 , pp. 3180-3187
    • George, S.1    Reichardt, P.2    Lechner, T.3
  • 75
    • 79957909038 scopus 로고    scopus 로고
    • Diastolic blood pressure as a biomarker of axitinib efficacy in solid tumors
    • Rini BI, Schiller JH, Fruehauf JP, et al. Diastolic blood pressure as a biomarker of axitinib efficacy in solid tumors. Clin Cancer Res 2011;17(11):3841-9
    • (2011) Clin Cancer Res , vol.17 , Issue.11 , pp. 3841-3849
    • Rini, B.I.1    Schiller, J.H.2    Fruehauf, J.P.3
  • 76
    • 33646810076 scopus 로고    scopus 로고
    • The SERIES clinic: An interdisciplinary approach to the management of toxicities of EGFR inhibitors
    • Lacouture ME, Basti S, Patel J, Benson A III. The SERIES clinic: an interdisciplinary approach to the management of toxicities of EGFR inhibitors. J Support Oncol 2006;4(5):236-8
    • (2006) J Support Oncol , vol.4 , Issue.5 , pp. 236-238
    • Lacouture, M.E.1    Basti, S.2    Patel, J.3    Iii., B.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.