메뉴 건너뛰기




Volumn 69 A, Issue 5, 2014, Pages 495-504

Evidence for less marked potential signs of T-cell immunosenescence in centenarian offspring than in the general age-matched population

Author keywords

Aging; Centenarian offspring; Immunosenescence; Longevity; T cells

Indexed keywords

ADULT; ADULT CHILD; AGE; AGED; AGING; ARTICLE; CASE CONTROL STUDY; CD4 CD8 RATIO; CENTENARIAN OFFSPRING.; FEMALE; HEALTH STATUS; HUMAN; IMMUNOLOGY; IMMUNOSENESCENCE; LONGEVITY; LYMPHOCYTE ACTIVATION; MALE; PHYSIOLOGY; T LYMPHOCYTE; VERY ELDERLY;

EID: 84899087325     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt120     Document Type: Article
Times cited : (14)

References (46)
  • 2
    • 84862776821 scopus 로고    scopus 로고
    • The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines
    • McElhaney JE, Zhou X, Talbot HK, et al. The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine. 2012;30:2060-2067
    • (2012) Vaccine , vol.30 , pp. 2060-2067
    • McElhaney, J.E.1    Zhou, X.2    Talbot, H.K.3
  • 5
    • 59249090000 scopus 로고    scopus 로고
    • Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals
    • Chidrawar S, Khan N, Wei W, et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol. 2009;155:423-432
    • (2009) Clin Exp Immunol , vol.155 , pp. 423-432
    • Chidrawar, S.1    Khan, N.2    Wei, W.3
  • 6
    • 68149148869 scopus 로고    scopus 로고
    • Biomarkers of human immunosenescence: Impact of Cytomegalovirus infection
    • Derhovanessian E, Larbi A, Pawelec G. Biomarkers of human immunosenescence: Impact of Cytomegalovirus infection. Curr Opin Immunol. 2009;21:440-445
    • (2009) Curr Opin Immunol , vol.21 , pp. 440-445
    • Derhovanessian, E.1    Larbi, A.2    Pawelec, G.3
  • 7
    • 11144267995 scopus 로고    scopus 로고
    • Age-related loss of na?e T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes
    • Lazuardi L, Jenewein B, Wolf AM, Pfister G, Tzankov A, Grubeck- Loebenstein B. Age-related loss of na?e T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology. 2005;114:37-43
    • (2005) Immunology , vol.114 , pp. 37-43
    • Lazuardi, L.1    Jenewein, B.2    Wolf, A.M.3    Pfister, G.4    Tzankov, A.5    Grubeck-Loebenstein, B.6
  • 8
    • 0033975581 scopus 로고    scopus 로고
    • Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
    • Franceschi C, Bonaf?M, Valensin S. Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine. 2000;18:1717-1720
    • (2000) Vaccine , vol.18 , pp. 1717-1720
    • Franceschi, C.1    Bonafm Valensin, S.2
  • 9
    • 29644433966 scopus 로고    scopus 로고
    • Evidence of genetic enrichment for exponential survival using a family approach: Leiden Longevity Study
    • Schoemaker M, De Craen AJ, De Meijer PH, et al. Evidence of genetic enrichment for exponential survival using a family approach: Leiden Longevity Study. Eur J Hum Genet. 2006;14:79-84
    • (2006) Eur J Hum Genet , vol.14 , pp. 79-84
    • Schoemaker, M.1    De Craen, A.J.2    De Meijer, P.H.3
  • 10
    • 78049489351 scopus 로고    scopus 로고
    • Hallmark features of immunosenescence are absent in familial longevity
    • Derhovanessian E, Maier AB, Beck R, et al. Hallmark features of immunosenescence are absent in familial longevity. J Immunol. 2010;185: 4618-4624
    • (2010) J Immunol , vol.185 , pp. 4618-4624
    • Derhovanessian, E.1    Maier, A.B.2    Beck, R.3
  • 12
    • 16644378795 scopus 로고    scopus 로고
    • Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring
    • Terry DF, Wilcox MA, McCormick MA, et al. Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring. J Am Geriatr Soc. 2004;52:2074-2076
    • (2004) J Am Geriatr Soc , vol.52 , pp. 2074-2076
    • Terry, D.F.1    Wilcox, M.A.2    McCormick, M.A.3
  • 13
    • 35248861556 scopus 로고    scopus 로고
    • The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    • Rose G, Passarino G, Scornaienchi V, et al. The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring. BMC Genomics. 2007;8:293
    • (2007) BMC Genomics , vol.8 , pp. 293
    • Rose, G.1    Passarino, G.2    Scornaienchi, V.3
  • 14
    • 77950282534 scopus 로고    scopus 로고
    • B cells compartment in centenarian offspring and old people
    • Colonna-Romano G, Buffa S, Bulati M, et al. B cells compartment in centenarian offspring and old people. Curr Pharm Des. 2010;16:604-608
    • (2010) Curr Pharm des , vol.16 , pp. 604-608
    • Colonna-Romano, G.1    Buffa, S.2    Bulati, M.3
  • 15
    • 70349412916 scopus 로고    scopus 로고
    • A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people
    • Colonna-Romano G, Bulati M, Aquino A, et al. A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Ageing Dev. 2009;130:681-690
    • (2009) Mech Ageing Dev , vol.130 , pp. 681-690
    • Colonna-Romano, G.1    Bulati, M.2    Aquino, A.3
  • 16
    • 84873445741 scopus 로고    scopus 로고
    • A novel B cell population revealed by a CD38/CD24 gating strategy: CD38-CD24- B cells in centenarian offspring and elderly people
    • forthcoming
    • Buffa S, Pellican?M, Bulati M, et al. A novel B cell population revealed by a CD38/CD24 gating strategy: CD38-CD24- B cells in centenarian offspring and elderly people. Age. 2012; forthcoming
    • (2012) Age
    • Buffa, S.1    Pellicanm Bulati, M.2
  • 17
    • 33947687864 scopus 로고    scopus 로고
    • Four functionally distinct populations of human effector-memory CD8+ T lymphocytes
    • Romero P, Zippelius A, Kurth I, et al. Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J Immunol. 2007;178:4112-4119
    • (2007) J Immunol , vol.178 , pp. 4112-4119
    • Romero, P.1    Zippelius, A.2    Kurth, I.3
  • 18
    • 49749119446 scopus 로고    scopus 로고
    • Multiparameter flow cytometric analysis of cd4 and cd8 t cell subsets in young and old people
    • Koch S, Larbi A, Derhovanessian E, ?zcelik D, Naumova E, Pawelec G. Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing. 2008;5:6
    • (2008) Immun Ageing , vol.5 , pp. 6
    • Koch, S.1    Larbi, A.2    Derhovanessian, E.3    Zcelik, D.4    Naumova, E.5    Pawelec, G.6
  • 19
    • 0030691757 scopus 로고    scopus 로고
    • Phenotypic and functional separation of memory and effector human CD8+ T cells
    • Hamann D, Baars PA, Rep MH, et al. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med. 1997;186:1407-1418
    • (1997) J Exp Med , vol.186 , pp. 1407-1418
    • Hamann, D.1    Baars, P.A.2    Rep, M.H.3
  • 20
    • 84856802632 scopus 로고    scopus 로고
    • Immune profiling of Alzheimer patients
    • Pellican?M, Larbi A, Goldeck D, et al. Immune profiling of Alzheimer patients. J Neuroimmunol. 2012;242:52-59
    • (2012) J Neuroimmunol , vol.242 , pp. 52-59
    • Pellicanm Larbi, A.1    Goldeck, D.2
  • 21
    • 18644378123 scopus 로고    scopus 로고
    • Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57
    • Ibegbu CC, Xu YX, Harris W, Maggio D, Miller JD, Kourtis AP. Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. J Immunol. 2005;174:6088-6094
    • (2005) J Immunol , vol.174 , pp. 6088-6094
    • Ibegbu, C.C.1    Xu, Y.X.2    Harris, W.3    Maggio, D.4    Miller, J.D.5    Kourtis, A.P.6
  • 23
  • 24
    • 11844275234 scopus 로고    scopus 로고
    • Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses
    • Eaton SM, Burns EM, Kusser K, Randall TD, Haynes L. Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J Exp Med. 2004;200:1613-1622
    • (2004) J Exp Med , vol.200 , pp. 1613-1622
    • Eaton, S.M.1    Burns, E.M.2    Kusser, K.3    Randall, T.D.4    Haynes, L.5
  • 26
    • 23944441502 scopus 로고    scopus 로고
    • T cell development and receptor diversity during aging
    • Goronzy JJ, Weyand CM. T cell development and receptor diversity during aging. Curr Opin Immunol. 2005;17:468
    • (2005) Curr Opin Immunol , vol.17 , pp. 468
    • Goronzy, J.J.1    Weyand, C.M.2
  • 30
    • 0035202615 scopus 로고    scopus 로고
    • Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals
    • Goronzy JJ, Fulbright JW, Crowson CS, Poland GA, O'Fallon WM, Weyand CM. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol. 2001;75: 12182-12187
    • (2001) J Virol , vol.75 , pp. 12182-12187
    • Goronzy, J.J.1    Fulbright, J.W.2    Crowson, C.S.3    Poland, G.A.4    O'fallon, W.M.5    Weyand, C.M.6
  • 31
    • 0036604275 scopus 로고    scopus 로고
    • Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
    • Saurwein-Teissl M, Lung TL, Marx F, et al. Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J. Immunol. 2002;168:5893-5899
    • (2002) J. Immunol , vol.168 , pp. 5893-5899
    • Saurwein-Teissl, M.1    Lung, T.L.2    Marx, F.3
  • 32
    • 58149301590 scopus 로고    scopus 로고
    • From bench to bedside and back: The SENIEUR Protocol and the efficacy of influenza vaccination in the elderly
    • Trzonkowski P, Myśliwska J, Pawelec G, Myśliwski A. From bench to bedside and back: The SENIEUR Protocol and the efficacy of influenza vaccination in the elderly. Biogerontology. 2009;10:83-94
    • (2009) Biogerontology , vol.10 , pp. 83-94
    • Trzonkowski, P.1    Myśliwska, J.2    Pawelec, G.3    Myśliwski, A.4
  • 33
    • 84868197202 scopus 로고    scopus 로고
    • Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects
    • Haynes L, Swain SL. Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects. Semin Immunol. 2012;24:350-355
    • (2012) Semin Immunol , vol.24 , pp. 350-355
    • Haynes, L.1    Swain, S.L.2
  • 34
    • 0037097657 scopus 로고    scopus 로고
    • Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals
    • Kern F, Bunde T, Faulhaber N, et al. Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals. J Infect Dis. 2002;185:1709
    • (2002) J Infect Dis , vol.185 , pp. 1709
    • Kern, F.1    Bunde, T.2    Faulhaber, N.3
  • 35
    • 14744281718 scopus 로고    scopus 로고
    • Long-Term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons
    • Almanzar G, Schwaiger S, Jenewein B, et al. Long-Term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons. J Virol. 2005;79:3675-3683
    • (2005) J Virol , vol.79 , pp. 3675-3683
    • Almanzar, G.1    Schwaiger, S.2    Jenewein, B.3
  • 38
    • 23944490475 scopus 로고    scopus 로고
    • Memory T cell homeostasis and senescence during aging
    • Akbar AN, Fletcher JM. Memory T cell homeostasis and senescence during aging. Curr Opin Immunol. 2005;17:480-485
    • (2005) Curr Opin Immunol , vol.17 , pp. 480-485
    • Akbar, A.N.1    Fletcher, J.M.2
  • 39
    • 24344489044 scopus 로고    scopus 로고
    • Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    • Sylwester AW, Mitchell BL, Edgar JB, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med. 2005;202:673-685
    • (2005) J Exp Med , vol.202 , pp. 673-685
    • Sylwester, A.W.1    Mitchell, B.L.2    Edgar, J.B.3
  • 40
    • 81255188983 scopus 로고    scopus 로고
    • Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans
    • pt12
    • Derhovanessian E, Maier AB, H?nel K, et al. Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. J Gen Virol. 2011;92(pt 12):2746-2756
    • (2011) J Gen Virol , vol.92 , pp. 2746-2756
    • Derhovanessian, E.1    Maier, A.B.2    Hnel, K.3
  • 41
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune
    • Wikby A, Johansson B, Olsson J, L?gren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune. Exp Gerontol. 2002;37:445-453
    • (2002) Exp Gerontol , vol.37 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3    Lgren, S.4    Nilsson, B.O.5    Ferguson, F.6
  • 42
    • 0037396188 scopus 로고    scopus 로고
    • Morbidity does not influence the T-cell immune risk phenotype in the elderly: Findings in the Swedish NONA Immune Study using sample selection protocols
    • N ilsson BO, Ernerudh J, Johansson B, et al. Morbidity does not influence the T-cell immune risk phenotype in the elderly: Findings in the Swedish NONA Immune Study using sample selection protocols. Mech Ageing Dev. 2003;124:469-476
    • (2003) Mech Ageing Dev , vol.124 , pp. 469-476
    • Nilsson, B.O.1    Ernerudh, J.2    Johansson, B.3
  • 43
    • 20544476197 scopus 로고    scopus 로고
    • An immune risk phenotype, cognitive impairment, and survival in very late life: Impact of allostatic load in Swedish octogenarian and nonagenarian humans
    • Wikby A, Ferguson F, Forsey R, et al. An immune risk phenotype, cognitive impairment, and survival in very late life: Impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci. 2005;60:556-565
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 556-565
    • Wikby, A.1    Ferguson, F.2    Forsey, R.3
  • 44
    • 20844437643 scopus 로고    scopus 로고
    • Post-Thymic in vivo proliferation of naive CD4+ T cells constrains the TCR repertoire in healthy human adults
    • Kohler S, Wagner U, Pierer M, et al. Post-Thymic in vivo proliferation of naive CD4+ T cells constrains the TCR repertoire in healthy human adults. Eur J Immunol. 2005;35:1987-1994
    • (2005) Eur J Immunol , vol.35 , pp. 1987-1994
    • Kohler, S.1    Wagner, U.2    Pierer, M.3
  • 45
    • 67650921447 scopus 로고    scopus 로고
    • Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease
    • Larbi A, Pawelec G, Witkowski JM, et al. Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease. J Alzheimers Dis. 2009;17:91-103
    • (2009) J Alzheimers Dis , vol.17 , pp. 91-103
    • Larbi, A.1    Pawelec, G.2    Witkowski, J.M.3
  • 46
    • 84872315230 scopus 로고    scopus 로고
    • Aging affects the proportions of T and B cells in a group of elderly men in a developing country- A pilot study from Pakistan
    • forthcoming
    • Alam I, Goldeck D, Larbi A, Pawelec G. Aging affects the proportions of T and B cells in a group of elderly men in a developing country- A pilot study from Pakistan. Age (Dordr). 2012; forthcoming. .
    • (2012) Age (Dordr)
    • Alam, I.1    Goldeck, D.2    Larbi, A.3    Pawelec, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.