Reductions in neuronal peroxisomes in multiple sclerosis grey matter

Multiple Sclerosis Journal

Volumn 20, Issue 6, 2014, Pages 651-659

  Gray, Elizabeth ^a   Rice, Claire ^a   Hares, Kelly ^a   Redondo, Juliana ^a   Kemp, Kevin ^a   Williams, Marcus ^b   Brown, Ann ^b   Scolding, Neil ^a   Wilkins, Alastair ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

Author keywords

grey matter; multiple sclerosis; Peroxisomes

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MEMBRANE PROTEIN; PEROXISOMAL MEMBRANE PROTEIN 70; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID; ABC TRANSPORTER; ABCD3 PROTEIN, HUMAN; HEXACOSANOIC ACID; LONG CHAIN FATTY ACID;

ADULT; AGED; ANTIBODY LABELING; ARTICLE; CALIBRATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; FEMALE; GENE EXPRESSION; GRAY MATTER; HUMAN; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PEROXISOME; PROTEIN EXPRESSION; VERY ELDERLY; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; ABCD3 GENE; CELL COUNT; CLINICAL ARTICLE; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; GAPDH GENE; GENE; GENETIC CODE; HUMAN CELL; HUMAN TISSUE; PATHOGENESIS;

ADULT; AGED; AGED, 80 AND OVER; ATP-BINDING CASSETTE TRANSPORTERS; FEMALE; GENE EXPRESSION; GRAY MATTER; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MULTIPLE SCLEROSIS; NEURONS; PEROXISOMES;

EID: 84899084987     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458513505691     Document Type: Article

References (29)

1. Kassmann CM, Lappe-Siefke C, Baes M, et al. Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nat Genet. 2007 ; 39: 969-976
2. Wanders RJ, Waterham HR. Biochemistry of mammalian peroxisomes revisited. Ann Rev Biochem. 2006 ; 75: 295-332
3. Bonekamp NA, Volkl A, Fahimi HD, et al. Reactive oxygen species and peroxisomes: Struggling for balance. Biofactors. 2009 ; 35: 346-355
4. Berger J, Gartner J. X-linked adrenoleukodystrophy: Clinical, biochemical and pathogenetic aspects. Biochim Biophys Acta. 2006 ; 1763: 1721-1732
5. Moser HW, Moser AE, Singh I, et al. Adrenoleukodystrophy: Survey of 303 cases: Biochemistry, diagnosis, and therapy. Ann Neurol. 1984 ; 16: 628-641
6. Aubourg P, Dubois-Dalcq M. X-linked adrenoleukodystrophy enigma: How does the ALD peroxisomal transporter mutation affect CNS glia?. Glia. 2000 ; 29: 186-190
7. Singh I, Paintlia AS, Khan M, et al. Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment. Brain Res. 2004 ; 1022: 1-11
8. Diczfalusy U. Beta-oxidation of eicosanoids. Prog Lipid Res. 1994 ; 33: 403-428
9. Bottelbergs A, Verheijden S, Hulshagen L, et al. Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes. Glia. 2010 ; 58: 1532-1543
10. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001 ; 25: 402-408
11. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 ; 226: 497-509
12. Onkenhout W, van der Poel PF, van den Heuvel MP. Improved determination of very-long-chain fatty acids in plasma and cultured skin fibroblasts: Applications to the diagnosis of peroxisomal disorders. J Chromatogr. 1989 ; 494: 31-41
13. Peterson JW, Bo L, Mork S, et al. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol. 2001 ; 50: 389-400
14. Vercellino M, Masera S, Lorenzatti M, et al. Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter. J Neuropathol Exp Neurol. 2009 ; 68: 489-502
15. Vercellino M, Merola A, Piacentino C, et al. Altered glutamate reuptake in relapsing-remitting and secondary progressive multiple sclerosis cortex: Correlation with microglia infiltration, demyelination, and neuronal and synaptic damage. J Neuropathol Exp Neurol. 2007 ; 66: 732-739
16. Wanders RJ. Peroxisomes, lipid metabolism, and peroxisomal disorders. Mol Genet Metab. 2004 ; 83: 16-27
17. Kou J, Kovacs GG, Hoftberger R, et al. Peroxisomal alterations in Alzheimer's disease. Acta Neuropathol. 2011 ; 122: 271-283
18. Hulshagen L, Krysko O, Bottelbergs A, et al. Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration. J Neurosci. 2008 ; 28: 4015-4027
19. Mar S, Noetzel M. Axonal damage in leukodystrophies. Pediatr Neurol. 2010 ; 42: 239-242
20. Bar-Or A, Oliveira EM, Anderson DE, et al. Molecular pathogenesis of multiple sclerosis. J Neuroimmunol. 1999 ; 100: 252-259
21. Dubois-Dalcq M, Feigenbaum V, Aubourg P. The neurobiology of X-linked adrenoleukodystrophy, a demyelinating peroxisomal disorder. Trends Neurosci. 1999 ; 22: 4-12
22. Paintlia AS, Gilg AG, Khan M, et al. Correlation of very long chain fatty acid accumulation and inflammatory disease progression in childhood X-ALD: Implications for potential therapies. Neurobiol Dis. 2003 ; 14: 425-439
23. Powers JM. The pathology of peroxisomal disorders with pathogenetic considerations. J Neuropathol Exp Neurol. 1995 ; 54: 710-719
24. Wilkins A, Ingram G, Brown A, et al. Very long chain fatty acid levels in patients diagnosed with multiple sclerosis. Mult Scler. 2009 ; 15: 1525-1527
25. Beier K, Volkl A, Fahimi HD. Suppression of peroxisomal lipid beta-oxidation enzymes of TNF-alpha. FEBS Letters. 1992 ; 310: 273-276
26. Contreras MA, Khan M, Smith BT, et al. Endotoxin induces structure-function alterations of rat liver peroxisomes: Kupffer cells released factors as possible modulators. Hepatology. 2000 ; 31: 446-455
27. Gilg AG, Singh AK, Singh I. Inducible nitric oxide synthase in the central nervous system of patients with X-adrenoleukodystrophy. J Neuropathol Exp Neurol. 2000 ; 59: 1063-1069
28. Yasmineh WG, Parkin JL, Caspers JI, et al. Tumor necrosis factor/cachectin decreases catalase activity of rat liver. Cancer Res. 1991 ; 51: 3990-3995
29. Wilkins A, Scolding N. Protecting axons in multiple sclerosis. Mult Scler. 2008 ; 14: 1013-1025