Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: Mechanism, function, and implication for a potential novel therapeutic target

Experimental Hematology

Volumn 42, Issue 4, 2014, Pages

  Ueno, Shikiko ^a   Lu, Jiayun ^a   He, Jie ^a   Li, Ailing ^a   Zhang, XiaoXian ^a   Ritz, Jerome ^b   Silberstein, Leslie E ^a   Chai, Li ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; SALL4 PROTEIN; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ACUTE B CELL LYMPHOBLASTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; TUMOR ENGRAFTMENT; TUMOR XENOGRAFT; UPREGULATION;

CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DNA METHYLATION; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; NEOPLASM PROTEINS; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TRANSCRIPTION FACTORS;

EID: 84899084708     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2014.01.005     Document Type: Article

References (30)

1. Pui C.H., Relling M.V., Downing J.R. Acute lymphoblastic leukemia. New Engl J Med 2004, 350:1535-1548.
2. Medvedovic J., Ebert A., Tagoh H., Busslinger M. Pax5: a master regulator of B cell development and leukemogenesis. Adv Immunol 2011, 111:179-206.
3. Kohlhase J., Heinrich M., Schubert L., et al. Okihiro syndrome is caused by SALL4 mutations. Hum Mol Genet 2002, 11:2979-2987.
4. Al-Baradie R., Yamada K., St Hilaire C., et al. Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. Am J Hum Genet 2002, 71:1195-1199.
5. Warren M., Wang W., Spiden S., et al. A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis. Genesis 2007, 45:51-58.
6. Wu Q., Chen X., Zhang J., et al. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem 2006, 281:24090-24094.
7. Wang J., Rao S., Chu J., et al. A protein interaction network for pluripotency of embryonic stem cells. Nature 2006, 444:364-368.
8. Zhang J., Tam W.L., Tong G.Q., et al. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol 2006, 8:1114-1123.
9. Kobayashi D., Kuribayshi K., Tanaka M., Watanabe N. SALL4 is essential for cancer cell proliferation and is overexpressed at early clinical stages in breast cancer. Int J Oncol 2011, 38:933-939.
10. Cao D., Guo S., Allan R.W., Molberg K.H., Peng Y. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol 2009, 33:894-904.
11. Ushiku T., Shinozaki A., Shibahara J., et al. SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol 2010, 34:533-540.
12. Deisch J., Raisanen J., Rakheja D. Immunoexpression of SALL4 in Wilms tumors and developing kidney. Pathol Oncol Res 2011, 17:639-644.
13. Liu A., Cheng L., Du J., et al. Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primary mediastinal germ cell tumors. Am J Surg Pathol 2010, 34:697-706.
14. Mei K., Liu A., Allan R.W., et al. Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases. Mod Pathol 2009, 22:1628-1636.
15. Wang F., Liu A., Peng Y., et al. Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alpha-fetoprotein, and glypican-3. Am J Surg Pathol 2009, 33:1529-1539.
16. Cao D., Humphrey P.A., Allan R.W. SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors. Cancer 2009, 115:2640-2651.
17. Cao D., Li J., Guo C.C., Allan R.W., Humphrey P.A. SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol 2009, 33:1065-1077.
18. Ma Y., Cui W., Yang J., et al. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood 2006, 108:2726-2735.
19. Cui W., Kong N.R., Ma Y., Amin H.M., Lai R., Chai L. Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod Pathol 2006, 19:1585-1592.
20. Yang J., Chai L., Gao C., et al. SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood 2008, 112:805-813.
21. Yang J., Chai L., Liu F., et al. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci U S A 2007, 104:10494-10499.
22. Jeong H.W., Cui W., Yang Y., et al. SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes. PLoS One 2011, 6:e18372.
23. Den Boer M.L., van Slegtenhorst M., De Menezes R.X., et al. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 2009, 10:125-134.
24. van Dongen J.J., Macintyre E.A., Gabert J.A., et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia 1999, 13:1901-1928.
25. Matsuno N., Hoshino K., Nanri T., et al. p15 mRNA expression detected by real-time quantitative reverse transcriptase-polymerase chain reaction correlates with the methylation density of the gene in adult acute leukemia. Leuk Res 2005, 29:557-564.
26. Yang J., Corsello T.R., Ma Y. Stem cell gene SALL4 suppresses transcription through recruitment of DNA methyltransferases. J Biol Chem 2012, 287:1996-2005.
27. Habano W., Sugai T., Jiao Y.F., Nakamura S. Novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy. Int J Cancer 2007, 121:1487-1493.
28. Harvey R.C., Mullighan C.G., Wang X., et al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood 2010, 116:4874-4884.
29. Gao C., Dimitrov T., Yong K.J., et al. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood 2013, 121:1413-1421.
30. Yong K.J., Chai L., Tenen D.G. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. New Engl J Med 2013, 369:1171-1172.