Synthesis and biological evaluation of 2,3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 9, 2014, Pages 2129-2133

  Tang, Zhichao ^a   Niu, Shaoxiong ^a   Liu, Fei ^a   Lao, Kejing ^a   Miao, Jingshan ^a   Ji, Jinzi ^a   Wang, Xiang ^a   Yan, Ming ^a   Zhang, Luyong ^a   You, Qidong ^a   Xiao, Hong ^b   Xiang, Hua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b THE AFFILIATED BRAIN HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

2 3 Diaryl isoquinolinone derivatives; Anti breast cancer; ER ; Synthesis; VEGFR 2

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA, HUMAN; ISOQUINOLINE DERIVATIVE; VASCULOTROPIN RECEPTOR 2;

ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST; BREAST NEOPLASMS; CHEMISTRY; CHICKEN; DRUG EFFECTS; FEMALE; HUMAN; METABOLISM; MOLECULAR DOCKING; PATHOLOGY; TUMOR CELL LINE;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; CHICKENS; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; ISOQUINOLINES; MOLECULAR DOCKING SIMULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84899083708     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.042     Document Type: Article

References (16)

1. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, and D.M. Parkin Int. J. Cancer. 127 2010 2893
2. S. Sommer, and S.A. Fuqua Semin. Cancer Biol. 11 2001 339
3. T.L. Wang, Q.D. You, F.S. Huang, and H. Xiang Mini-Rev. Med. Chem. 9 2009 1191
4. L.M. McGlynn, T. Kirkegaard, J. Edwards, S. Tovey, D. Cameron, C. Twelves, J.M.S. Bartlett, and T.G. Cooke Clin. Cancer Res. 15 2009 1487
5. P. Ascenzi, A. Bocedi, and M. Marino Mol. Asp. Med. 27 2006 299
6. Z. Madak-Erdogan, M. Lupien, F. Stossi, M. Brown, and B.S. Katzenellenbogen Mol. Cell. Biol. 31 2011 226
7. A. LongattoFilho, J.M. Lopes, and F.C. Schmitt J. Oncol. 2010 2010
8. D.J. Hicklin, and L.M. Ellis J. Clin. Oncol. 23 2005 1011
9. D. Huang, Y. Ding, W.M. Luo, S. Bender, C.N. Qian, E. Kort, Z.F. Zhang, K. VandenBeldt, N.S. Duesbery, J.H. Resau, and B.T. Teh Cancer Res. 68 2008 81
10. G. Mavria, Y. Vercoulen, M. Yeo, H. Paterson, M. Karasarides, R. Marais, D. Bird, and C.J. Marshall Cancer Cell. 9 2006 33
11. M.E. Fratto, M. Imperatori, B. Vincenzi, F. Tomao, D. Santini, and G. Tonini Clin. Ter. 161 2010 475
12. G. Ranieri, R. Patruno, E. Ruggieri, S. Montemurro, P. Valerio, and D. Ribatti Curr. Med. Chem. 13 2006 1845
13. R.R. Patel, S. Sengupta, H.R. Kim, A.J. Klein-Szanto, J.R. Pyle, F. Zhu, T. Li, E.A. Ross, S. Oseni, J. Fargnoli, and V.C. Jordan Eur. J. Cancer. 46 2010 1537
14. R.A. Hill, S. Rudra, B. Peng, D.S. Roane, J.K. Bounds, Y. Zhang, A. Adloo, and T. Lu Bioorg. Med. Chem. 11 2003 2099
15. D.G. Lloyd, H.M. Smith, T. O'Sullivan, D.M. Zisterer, and M.J. Meegan J. Med. Chem. 1 2005 335
16. A.D. Palkowitz, A.L. Glasebrook, K.J. Thrasher, K.L. Hauser, L.L. Short, D.L. Phillips, B.S. Muehl, M. Sato, P.K. Shetler, G.J. Cullinan, T.R. Pell, and H.U. Bryant J. Med. Chem. 40 1997 1407