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This is a very interesting study which showed that prenatal exposure to cockroach allergen among Dominican and African-American pregnant women in New York was associated with a greater risk of allergic sensitization at the ages of 5-7 years. This risk was increased only among children who were also exposed to nonvolatile polycyclic aromatic hydrocarbons (PAHs), with children null for the Glutathione-S-transferase μ 1 (GSTM1) mutation being particularly vulnerable. The study highlights the fact that combustion byproducts can act as adjuvants in the development of cockroach sensitization in urban environments
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Perzanowski MS, Chew GL, Divjan A, Jung KH, Ridder R, Tang D, et al. Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children. J Allergy Clin Immunol. 2013;131:886-93. This is a very interesting study which showed that prenatal exposure to cockroach allergen among Dominican and African-American pregnant women in New York was associated with a greater risk of allergic sensitization at the ages of 5-7 years. This risk was increased only among children who were also exposed to nonvolatile polycyclic aromatic hydrocarbons (PAHs), with children null for the Glutathione-S-transferase μ 1 (GSTM1) mutation being particularly vulnerable. The study highlights the fact that combustion byproducts can act as adjuvants in the development of cockroach sensitization in urban environments.
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In this study, the authors report an interesting observation, that increasing exposure to cockroach allergen in the home is associated not only with increasing in IgE to cockroach but also with increasing in IgE to shrimp. This could be due to cross-reactive IgE responses to shared allergens, including tropomyosin
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Wang J, Calatroni A, Visness CM, Sampson HA. Correlation of specific IgE to shrimp with cockroach and dust mite exposure and sensitization in an inner-city population. J Allergy Clin Immunol. 2011;128:834-7. In this study, the authors report an interesting observation, that increasing exposure to cockroach allergen in the home is associated not only with increasing in IgE to cockroach but also with increasing in IgE to shrimp. This could be due to cross-reactive IgE responses to shared allergens, including tropomyosin.
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