Differential T-cell responses of semi-immune and susceptible malaria subjects to in silico predicted and synthetic peptides of Plasmodium falciparum

Acta Tropica

Volumn 135, Issue 1, 2014, Pages 104-121

  Dinga, Jerome Nyhalah ^a   Kimbung Mbandi, Stanley ^a,d   Cho Ngwa, Fidelis ^a   Fon, Nde Peter ^a   Moliki, Johnson ^a   Efeti, Rose Mary ^a   Nyasa, Babila Raymond ^a   Anong, Damian Nota ^a   Jojic, Nebojsa ^c   Heckerman, David ^c   Wang, Ruobing ^b   Titanji, Vincent P K ^a  

^a UNIVERSITY OF BUEA   (Cameroon)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c MICROSOFT   (United States)

^d UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

ELISPOT; Interferon gamma; Malaria; T cell epitope; Vaccine

Indexed keywords

EPITOPE; GAMMA INTERFERON; MALARIA VACCINE; SYNTHETIC PEPTIDE; PARASITE ANTIGEN; PEPTIDE; PROTOZOAL PROTEIN;

ANTIBODY; BLOOD; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; MALARIA; PARASITE; PEPTIDE; PROTEIN; VACCINE;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSPOT ASSAY; ENZYME SYNTHESIS; EX VIVO STUDY; FEMALE; GENE LOCUS; HUMAN; LYMPHOCYTE DIFFERENTIATION; MALARIA; MALE; NUTRITIONAL STATUS; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMODIUM FALCIPARUM; PROTEIN ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; COMPUTER SIMULATION; GENETICS; IMMUNOLOGY; MALARIA FALCIPARUM; MIDDLE AGED; SECRETION (PROCESS); YOUNG ADULT;

ADULT; ANTIGENS, PROTOZOAN; COMPUTER SIMULATION; ENZYME-LINKED IMMUNOSPOT ASSAY; FEMALE; HUMANS; INTERFERON-GAMMA; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; PEPTIDES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; T-LYMPHOCYTES; YOUNG ADULT;

EID: 84899058630     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2014.03.007     Document Type: Article

References (31)

1. Bejon P., Mwacharo J., Kai O., Todryk S., Keating S., Lowe B., Lang T., Mwangi T.W., Gilbert S.C., Peshu N., Marsh K., Hill A.V.S. The induction and persistence of T Cell IFN-γ responses after vaccination or natural exposure is suppressed by Plasmodium falciparum. J. Immunol. 2007, 179:4193-4201.
2. Dolo A., Modiano D., Doumbo O., Bosman A., Sidibé T., Keita M.M., Naitza S., Robson K.J., Crisanti A. Thrombospondin related adhesive protein (TRAP), a potential malaria vaccine candidate. Parassitologia 1999, 41:425-428.
3. Doolan D.L., Southwood S., Chestnut R., Appella E., Gomez E., Richards A., Higashimoto Y.I., Maewal A., Sidney J., Graamzinski R.A., Mason C., Keoch D., Hoffman S.L., Sette A. HLA-DR-Promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic stage antigens restricted by multiple HLA Class II alleles. J. Immunol. 2000, 165:1123-1137.
4. Epstein J.E., Giersing B., Mullen G., Moorthy V., Richie T.L. Malaria vaccines: are we getting closer?. Curr. Opin. Mol. Ther. 2007, 9:12-24.
5. Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K., Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 2002, 419:498-511.
6. Garraud O., Diouf A., Nguer C.M., Dieye A., Longacre S., Kaslow D.C., Holder A.A., Tall A., Molez J.F., Perraut R., Mercereau-Puijalon O. Different Plasmodium falciparum recombinant MSP1(19) antigens differ in their capacities to stimulate in vitro peripheral blood T lymphocytes in individuals from various endemic areas. Scand. J. Immunol. 1999, 49:431-440.
7. Good M.F., Doolan D.L. Immune effector mechanisms in malaria. Curr. Opin. Immunol. 1999, 11:412-419.
8. Greenwood B. Malaria vaccines evaluation and implementation. Acta Trop. 2005, 95:294-304.
9. Heckerman D., Kadie C., Listgarten J. Leveraging information across HLA alleles/supertypes improves epitope prediction. J. Comput. Biol. 2007, 14:736-746.
10. Hoffman S.L., Goh L.M.L., Luke T.C., Schneider I., Thong P., Le T.P., Doolan D.L., Sacci J., De la Vega P., Dowler M., Paul C., Gordon D.M., Stoute J.A., Church L.W.P., Sedegah M., Heppner D.G., Ballou W.R., Richie T.L. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J. Infect. Dis. 2002, 185:1155-1164.
11. Hoffman S., Franke M., Hollingdale R., Druilhe P. Attacking the infected hepatocyte. Malaria Vaccine Development 1996, 35. ASM Press, Washington, DC. S.L. Hoffman (Ed.).
12. Jennifer F.F., Kwena A.M., Mirel L.B., Kariuki S.K., Terlouw D.J., Phillips-Howard P.A., Hawley W.A., Nahlen B.L., Shi Y.P., Terkuil F.O. Malaria and nutritional status among pre-school children: result from cross sectional surveys in Western Kenya. Am. Soc. Trop. Med. Hyg. 2005, 73:698-704.
13. Jiang G., Charoenvit Y., Moreno A., Baraceros M.F., Banania G., Richie N., Abot S., Ganeshan H., Fallarme V., Patterson N.B., Geall A., Weiss W.R., Strobert E., Caro-Aquilar I., Lanar D.E., Saul A., Martin L.B., Gowda K., Morrissette C.R., Kaslow D.C., Carucci D.J., Galinski M.R., Doolan D. Induction of multi-antigen multi-stage immune responses against Plasmodium falciparum in rhesus monkeys, in the absence of antigen interference, with heterologous DNA prime/poxvirus boost immunization. Malar. J. 2007, 6:135.
14. Jojic N., Jojic V., Frey B., Meek C., Heckerman D. Using epitomes to model genetic diversity: rational design of HIV vaccine cocktails. Proceedings of Neural Information Processing Systems (NIPS): 19th Annual Conference on Neural Information Processing Systems 2005.
15. Kulangara C., Luedin S., Dietz O., Rusch S., Mueller D., Moser M., Kajava A.V., Corradin G., Frank G., Beck H.P., Felger I. Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1. PLoS One 2012, 7(10):e46112. doi:10.371.
16. Kiprotich C., Peter O., Sumba O., James W., Ayub V., Ofula Chandy C. Interferon gamma responses to Plasmodium falciparum liver stage antigen-1 and merozoite surface protein-1 increase with age in children in a malaria holoendemic area of western Kenya. Malar. J. 2003, 2:37.
17. Lobo C.A., Kar S.K., Ravindran B., Kabilan L., Sharma S. Novel proteins of Plasmodium falciparum identified by differential immunoscreening using immune and patient sera. Infect. Immun. 1994, 62:651-656.
18. Marsh K., Kinyanjui S. Immune effector mechanisms in malaria. Para Immunol. 2006, 28:56-60.
19. Matuschewski K., Mueller A.-K. Vaccine against malaria-an update. FEBS J. 2007, 274:4680-4687.
20. Nkuo-Akenji T.K., Ntonifor N.N., Ching J.K., Kimbi H.K., Ndamukong N.K., Anong D.N., Boyo M.G., Titanji V.P.K. Evaluating a malaria intervention strategy using knowledge, practices and coverage surveys in rural Bolifamba, Southwest Cameroon. Trans. R. Soc. Trop. Med. Hyg. 2005, 99:325-332.
21. Perlaza B.-L., Sauzet J.-P., Brahimi K., BenMohamed L., Druilhe P. Interferon-γ, a valuable surrogate marker of Plasmodium falciparum pre-erythrocytic stages protective immunity. Malar. J. 2011, 10:27.
22. Perlmann H., Perlmann P., Pape G.R., Halld G. Purification, fractionation and assay of antibody dependent lymphocytic effector cells (K-cells) in human blood. Scand. J. Immunol. 1976, 5(Suppl. 5):57.
23. Pinder M., Reece W.H.H., Plebanski M., Akinwunmi P., Flanagan K.L., Lee E.A.M., Doherty T., Milligan P., Jaye A., Tornieporth N., Ballous R., Mcadam K.P.M.J., Cohen J., Hill A.V.S. Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS, S/AS02, in semi-immune adults in The Gambia. Clin. Exp. Immunol. 2004, 135:286-293.
24. Schwartz L., Brown V.G., Genton B., Moorthy S.V. A review of malaria vaccine clinical projects based on the WHO rainbow table. Malar. J. 2012, 11:11.
25. Shi Q., Lynch M.M., Romero M., Burns J.M. Enhanced protection against malaria by a chimeric merozoite surface protein Vaccine. Infect. Immun. 2007, 75:1349-1358.
26. The EuPathDB Project Team: Sequence retrieval, Retrieved October 12, 2011. From www.plasmodb.org. PlasmoDB 9.0.
27. Titanji V.P., Amambua-Ngwa A., Teneng I., Tangyie E., Anong D., Akenji T. A epidemiological approach to malaria vaccine discovery: hypothesis and preliminary results. J. Cameroon. Acad. Sci. 2005, 5:49-57.
28. Titanji V.P., Nkuo-Akenji T., Ntopi W., Djokam R. Reduced levels of chloroquine resistant Plasmodium falciparum in selected foci of the South West Province, Cameroon. Cent. Afr. J. Med. 2001, 47:145-149.
29. Titanji V.P.K., Ngwa A.A., Anong D.N., Mbandi S.K., Tangie E., Tening I., Yengo R. Isolation and expression of UB05, a Plasmodium falciparum antigen recognised by antibodies from semi-immune adults in a high transmission endemic area of the Cameroonian rainforest. Clin. Chem. Lab. Med. 2009, 47:1147-1158.
30. Torimiro J.N., Carr J.K., Wolfe N.D., Karacki P., Martin M.P., Gao X., Tamoufe U., Thomas A., Ngole E.M., Birx D.L., McCutchan F.E., Burke D.S., Carrington M. HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype. Tissue Antigens 2006, 67:30.
31. WHO (World Health Organization) World Malaria Report, 2013 2013, WHO, Geneva, Switzerland.