German nationwide data on current trends and management of acute myocardial infarction: Discrepancies between trials and real-life

European Heart Journal

Volumn 35, Issue 15, 2014, Pages 979-988

  Freisinger, Eva ^a   Fuerstenberg, Torsten ^b   Malyar, Nasser M ^a   Wellmann, Juergen ^c   Keil, Ulrich ^c   Breithardt, Guenter ^a   Reinecke, Holger ^a,d  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b IGES Institut GmbH   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d DRG Research Group   (Germany)

Author keywords

Acute myocardial infarction; Cardiovascular disease; Mortality; Population based study

Indexed keywords

FIBRINOGEN RECEPTOR ANTAGONIST; HIRULOG;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; CHRONIC KIDNEY DISEASE; COMORBIDITY; COST OF ILLNESS; DATA ANALYSIS; DIABETES MELLITUS; FEMALE; GERMANY; HEART LEFT VENTRICLE FAILURE; HOSPITAL COST; HOSPITALIZATION; HUMAN; HYPERTENSION; MALE; MORBIDITY; MORTALITY; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; SYMPTOMATOLOGY; CLINICAL PRACTICE; CORONARY ARTERY BYPASS GRAFT; COST; ECONOMICS; FIBRINOLYTIC THERAPY; MIDDLE AGED; MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); STENT; TRENDS;

AGED; CORONARY ARTERY BYPASS; COSTS AND COST ANALYSIS; FEMALE; GERMANY; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PHYSICIAN'S PRACTICE PATTERNS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STENTS; THROMBOLYTIC THERAPY;

EID: 84899009111     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu043     Document Type: Article

References (52)

1. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Greenlund KJ, Hailpern SM, Heit JA, Ho PM, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-Rosett J. Heart disease and stroke statistics-2011 update: A report from the American Heart Association. Circulation 2010;123:e18-e209
2. Smith SC Jr., Collins A, Ferrari R, Holmes DR Jr, Logstrup S, McGhie DV, Ralston J, Sacco RL, Stam H, Taubert K, Wood DA, ZoghbiWA. Our time: A call to save preventable death from cardiovascular disease (heart disease and stroke). Eur Heart J 2012;33:2910-2916
3. Van DeWerf F, Bax J, Betriu A, Blomstrom-Lundqvist C, Crea F, Falk V, Filippatos G, Fox K, Huber K, Kastrati A, Rosengren A, Steg PG, Tubaro M, Verheugt F, Weidinger F, Weis M. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: The Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2008;29:2909-2945
4. Lee PY, Alexander KP, Hammill BG, Pasquali SK, Peterson ED. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA 2001;286:708-713
5. Rathore SS, Weinfurt KP, Gross CP, Krumholz HM. Validity of a simple ST-elevation acute myocardial infarction risk index: Are randomized trial prognostic estimates generalizable to elderly patientš. Circulation 2003;107:811-816
6. EUROASPIRE II Study Group. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries; principal results from EUROASPIRE II Euro Heart Survey Programme. Eur Heart J 2001;22:554-572
7. Fox KA, Goodman SG, KleinW, Brieger D, Steg PG, Dabbous O, Avezum A. Management of acute coronary syndromes. Variations in practice and outcome; findings from the Global Registry of Acute Coronary Events (GRACE). Eur Heart J 2002;23: 1177-1189
8. Fox KA, Cokkinos DV, Deckers J, Keil U, Maggioni A, Steg G. The ENACT study: A pan-European survey of acute coronary syndromes. European Network for Acute Coronary Treatment. Eur Heart J 2000;21:1440-1449
9. Mandelzweig L, Battler A, Boyko V, Bueno H, Danchin N, Filippatos G, Gitt A, Hasdai D, Hasin Y, Marrugat J, Van De Werf F, Wallentin L, Behar S. The second Euro Heart Survey on acute coronary syndromes: Characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004. Eur Heart J 2006;27:2285-2293
10. EUROASPIRE.AEuropean Society of Cardiology survey of secondary prevention of coronary heart disease: Principal results. EUROASPIRE Study Group. European Action on Secondary Prevention through Intervention to Reduce Events. Eur Heart J 1997;18:1569-1582
11. Kuch B, Heier M, von ScheidtW, Kling B, Hoermann A, Meisinger C. 20-year trends in clinical characteristics, therapy and short-Term prognosis in acute myocardial infarction according to presenting electrocardiogram: The MONICA/KORA AMI Registry (1985-2004). J Intern Med 2008;264:254-264
12. Wang OJ, Wang Y, Chen J, Krumholz HM. Recent trends in hospitalization for acute myocardial infarction. Am J Cardiol 2012;109:1589-1593
13. McManus DD, Gore J, Yarzebski J, Spencer F, Lessard D, Goldberg RJ. Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI. Am J Med 2010;124:40-47
14. Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, Newby LK, Pina IL, Roger VL, Shaw LJ, Zhao D, Beckie TM, Bushnell C, D'Armiento J, Kris-Etherton PM, Fang J, Ganiats TG, Gomes AS, Gracia CR, Haan CK, Jackson EA, Judelson DR, Kelepouris E, Lavie CJ, Moore A, Nussmeier NA, Ofili E, Oparil S, Ouyang P, Pinn VW, Sherif K, Smith SC Jr, Sopko G, Chandra-Strobos N, Urbina EM, Vaccarino V, Wenger NK. Effectiveness-based guidelines for the prevention of cardiovascular disease in women-2011 update: A guideline from the American Heart Association. Circulation 2011;123:1243-1262
15. Sargent JD, Demidenko E, Malenka DJ, Li Z, Gohlke H, Hanewinkel R. Smoking restrictions and hospitalization for acute coronary events in Germany. Clin Res Cardiol 2012;101:227-235
16. Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Keil U. Cardiovascular prevention guidelines in daily practice: A comparison of EUROASPIRE I, II, and III surveys in eight European countries. Lancet 2009;373:929-940
17. DeFrances CJ, Lucas CA, Buie VC, Golosinskiy A. 2006 National Hospital Discharge Survey. Natl Health Stat Report 2008;5:1-20
18. Keller T, Zeller T, Peetz D, Tzikas S, Roth A, Czyz E, Bickel C, Baldus S, Warnholtz A, Frohlich M, Sinning CR, Eleftheriadis MS, Wild PS, Schnabel RB, Lubos E, Jachmann N, Genth-Zotz S, Post F, Nicaud V, Tiret L, Lackner KJ, Munzel TF, Blankenberg S. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009;361:868-877
19. Parikh NI, Gona P, Larson MG, Fox CS, Benjamin EJ, Murabito JM, O'Donnell CJ, Vasan RS, Levy D. Long-Term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study. Circulation 2009;119:1203-1210
20. Roger VL, Killian JM, Weston SA, Jaffe AS, Kors J, Santrach PJ, Tunstall-Pedoe H, Jacobsen SJ. Redefinition of myocardial infarction: Prospective evaluation in the community. Circulation 2006;114:790-797
21. Myocardial infarction redefined-A consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J 2000;21:1502-1513
22. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined-A consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 2000;36:959-969
23. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study. Lancet 2004;364:937-952
24. BoyerNM, Laskey WK, Cox M, Hernandez AF, Peterson ED, Bhatt DL, Cannon CP, Fonarow GC. Trends in clinical, demographic, and biochemical characteristics of patients with acute myocardial infarction from 2003 to 2008: A report from the american heart association get with the guidelines coronary artery disease program. J Am Heart Assoc 2012;1:e001206
25. Zhang Z, Fang J, Gillespie C, Wang G, Hong Y, YoonPW. Age-specific gender differences in in-hospital mortality by type of acute myocardial infarction. Am J Cardiol 2012;109:1097-1103
26. Rogers WJ, Frederick PD, Stoehr E, Canto JG, Ornato JP, Gibson CM, PollackCV Jr., Gore JM, Chandra-Strobos N, Peterson ED, French WJ. Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006. Am Heart J 2008;156:1026-1034
27. Mannsverk J, Wilsgaard T, Njolstad I, Hopstock LA, Lochen ML, Mathiesen EB, Thelle DS, Rasmussen K, Bonaa KH. Age and gender differences in incidence and case fatality trends for myocardial infarction: A 30-year follow-up. The Tromso Study. Eur J Prev Cardiol 2011;19:927-934
28. Yang D, Dzayee DA, Beiki O, de Faire U, Alfredsson L, Moradi T. Incidence and case fatality after day 28 of first time myocardial infarction in Sweden 1987-2008. Eur J Prev Cardiol 2011;19:1304-1315
29. Lehto HR, Lehto S, Havulinna AS, Ketonen M, Lehtonen A, Kesaniemi YA, Airaksinen J, Salomaa V. Are coronary event rates declining slower in women than in men-evidence from two population-based myocardial infarction registers in Finland?. BMC Cardiovasc Disord 2007;7:35
30. Polonski L, Gasior M, Gierlotka M, Kalarus Z, Cieslinski A, Dubiel JS, Gil RJ, RuzylloW, Trusz-Gluza M, Zembala M, Opolski G. Polish Registry of Acute Coronary Syndromes (PL-ACS). Characteristics, treatments and outcomes of patients with acute coronary syndromes in Poland. Kardiol Pol 2007;65:861-872; discussion 873-864
31. Goodman SG, Huang W, Yan AT, Budaj A, Kennelly BM, Gore JM, Fox KA, Goldberg RJ, Anderson FA Jr. The expanded Global Registry of Acute Coronary Events: Baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes. Am Heart J 2009;158:193-201 e191-195
32. Lawesson SS, Alfredsson J, Fredrikson M, Swahn E. Time trends in STEMI-improved treatment and outcome but still a gender gap: A prospective observational cohort study from the SWEDEHEART register. BMJ Open 2012;2:e000726
33. McManus DD, Gore J, Yarzebski J, Spencer F, Lessard D, Goldberg RJ. Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI. Am J Med 2011;124:40-47
34. Montalescot G, Wiviott SD, Braunwald E, Murphy SA, Gibson CM, McCabe CH, Antman EM. Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): Double-blind, randomised controlled trial. Lancet 2009;373:723-731
35. Cannon CP, Harrington RA, James S, Ardissino D, Becker RC, Emanuelsson H, Husted S, Katus H, Keltai M, Khurmi NS, Kontny F, Lewis BS, Steg PG, Storey RF, Wojdyla D, Wallentin L. Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): A randomised double-blind study. Lancet 2010;375:283-293
36. Rittger H, Hochadel M, Behrens S, Hauptmann KE, Zahn R, Mudra H, Brachmann J, Senges J, Zeymer U. Age-related differences in diagnosis, treatment and outcome of acute coronary syndromes: Results from the German ALKK registry. EuroIntervention 2012;7:1197-1205
37. Hanssen M, Cottin Y, Khalife K, Hammer L, Goldstein P, Puymirat E, Mulak G, Drouet E, Pace B, Schultz E, Bataille V, Ferrieres J, Simon T, Danchin N. French Registry on Acute ST-elevation and non ST-elevation Myocardial Infarction 2010. FAST-MI 2010. Heart 2012;98:699-705
38. Sala C, Grau M, Masia R, Vila J, Subirana I, Ramos R, Aboal J, Sureda A, Brugada R, Marrugat J, Sala J, Elosua R. Trends in Q-wave acute myocardial infarction case fatality from 1978 to 2007 and analysis of the effectiveness of different treatments.AmHeart J 2011;162:444-450
39. Lawesson SS, Alfredsson J, Fredrikson M, Swahn E. Time trends in STEMI-improved treatment and outcome but still a gender gap: A prospective observational cohort study from the SWEDEHEART register. BMJ Open 2012;2:e000726
40. Gale CP, Cattle BA, Woolston A, Baxter PD, West TH, Simms AD, Blaxill J, Greenwood DC, Fox KA, West RM. Resolving inequalities in carë. Reduced mortality in the elderly after acute coronary syndromes. The Myocardial Ischaemia National Audit Project 2003-2010. Eur Heart J 2011;33:630-639
41. Di Chiara A, Chiarella F, Savonitto S, Lucci D, Bolognese L, De Servi S, Greco C, Boccanelli A, Zonzin P, Coccolini S, Maggioni AP. Epidemiology of acute myocardial infarction in the Italian CCU network: The BLITZ study. Eur Heart J 2003;24: 1616-1629
42. Fang J, Alderman MH, Keenan NL, Ayala C. Acute myocardial infarction hospitalization in the United States, 1979 to 2005. Am J Med 2010;123:259-266
43. Roger VL, Weston SA, Gerber Y, Killian JM, Dunlay SM, Jaffe AS, Bell MR, Kors J, Yawn BP, Jacobsen SJ. Trends in incidence, severity, and outcome of hospitalized myocardial infarction. Circulation 2010;121:863-869
44. Koopman C, Bots ML, van Oeffelen AA, Van Dis I, Verschuren WM, Engelfriet PM, Capewell S, Vaartjes I. Population trends and inequalities in incidence and short-Term outcome of acute myocardial infarction between 1998 and 2007. Int J Cardiol 2012; 168:993-998
45. Abildstrom SZ, Rasmussen S, Madsen M. Significant decline in case fatality after acute myocardial infarction in Denmark-A population-based study from 1994 to 2001. Scand Cardiovasc J 2002;36:287-291
46. Smolina K, Wright FL, Rayner M, Goldacre MJ. Determinants of the decline in mortality from acute myocardial infarction in England between 2002 and 2010: Linked national database study. BMJ 2012;344:d8059
47. Fox KA, Steg PG, Eagle KA, Goodman SG, Anderson FA Jr., Granger CB, Flather MD, Budaj A, Quill A, Gore JM. Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. JAMA 2007;297:1892-1900
48. Wijeysundera HC, Machado M, Farahati F, Wang X, WittemanW, Van Der Velde G, Tu JV, Lee DS, Goodman SG, Petrella R, O'Flaherty M, Krahn M, Capewell S. Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005. JAMA 2010;303:1841-1847
49. Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, Kottke TE, Giles WH, Capewell S. Explaining the decrease in U.S. deaths from coronary disease, 1980-2000. N Engl J Med 2007;356:2388-2398
50. Goldberg RJ, Spencer FA, Gore JM, Lessard D, Yarzebski J. Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: A populationbased perspective. Circulation 2009;119:1211-1219
51. Nguyen HL, Lessard D, Spencer FA, Yarzebski J, Zevallos JC, Gore JM, Goldberg RJ. Thirty-year trends (1975-2005) in the magnitude and hospital death rates associated with complete heart block in patients with acute myocardial infarction: A population-based perspective. Am Heart J 2008;156:227-233
52. Mercado-Martinez J, Rivera-Fernandez R, Aguilar-Alonso E, Garcia-Alcantara A, Estivill-Torrull A, Aranda-Leon A, Guia-Rambla MC, Fuset-Cabanes MP. APACHE-II score and Killip class for patients with acute myocardial infarction. Intensive Care Med 2010;36:1579-1586