Age-related differences in diagnosis, treatment and outcome of acute coronary syndromes: Results from the German ALKK registry

EuroIntervention

Volumn 7, Issue 10, 2012, Pages 1197-1205

  Rittger, Harald ^a   Hochadel, Matthias ^b   Behrens, Steffen ^d   Hauptmann, Karl Eugen ^e   Zahn, Ralf ^f   Mudra, H ^c   Brachmann, Johannes ^a   Senges, Jochen ^b   Zeymer, Uwe ^e  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Klinikum Neuperlach   (Germany)

^d VIVANTES HOSPITAL   (Germany)

^e KRANKENHAUS DER BARMHERZIGEN BRÜDER   (Germany)

^f KLINIKUM LUDWIGSHAFEN   (Germany)

Author keywords

Angiography; Angioplasty; Elderly; Non STEMI; STEMI

Indexed keywords

FONDAPARINUX; HEPARIN; HIRULOG; LOW MOLECULAR WEIGHT HEPARIN;

ACUTE CORONARY SYNDROME; ADULT; AGE; AGED; ANGIOCARDIOGRAPHY; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DISEASE ASSOCIATION; DISEASE REGISTRY; ELDERLY CARE; FEMALE; GERMANY; HUMAN; INVASIVE PROCEDURE; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TREATMENT RESPONSE;

ACUTE CORONARY SYNDROME; AGE FACTORS; AGED; AGED, 80 AND OVER; ANGIOPLASTY, BALLOON, CORONARY; CORONARY ANGIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; FIBRINOLYTIC AGENTS; GERMANY; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; REGISTRIES; RETROSPECTIVE STUDIES; RISK FACTORS; STROKE; TREATMENT OUTCOME;

EID: 84858326053     PISSN: 1774024X     EISSN: 19696213     Source Type: Journal    
DOI: 10.4244/EIJV7I10A191     Document Type: Article

References (25)

1. Avezum A, Makdisse M, Spencer F, Gore JM, Fox KA, Montalescot G, Eagle KA, White K, Mehta RH, Knobel E, Collet JE; Grace Investigators. Impact of age on management and outcome of ACS: Observations from the GRACE registry. Am Heart J. 2005;149:67-73. (Pubitemid 40126492)
2. Mehta R, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. Acute myocardial infarction in the elderly: differences by age. J Am Coll Cardiol. 2001;38:736-741. (Pubitemid 32835745)
3. Gilat D, Goldbourt U, Reicher-Reiss H, Zion M, Kaplinksi E, Behar S. Prognosis of acute myocardial infarct in the elderly - SPRINT Study Group. Harefuah. 1993;124:601-3.
4. Hasdai D, Holmes DR Jr., Cirger DA, Topol EJ, Califf RM, Harrington RA. Age and outcome after acute coronary syndromes without persistent ST-segment elevation. AM Heart J. 2000;139:856-66.
5. Devlin G, Gore JM, Elliott J, Wijesinghe N, Eagle KA, Avezum A, Huang W, Brieger D; GRACE Investigators. Management and 6-month outcomes in elderly and very elderly patients with high-risk non-ST-elevation acute coronary syndromes: The Global Registry of Acute Coronary Events. Eur Heart J. 2008;10:1275-82. (Pubitemid 351768128)
6. Rosengren A, Wallentin L, Simoons M, Gitt AK, Behar S, Battler A, Hasdai D. Age, clinical presentation, and outcome of acute coronary syndromes in the Euroheart acute coronary syndrome survey. Eur Heart J. 2006;27:789-795.
7. Yusuf S, Flather M, Pogue J, Hunt D, Varigos J, Piegas L, Avezum A, Anderson J, Keltai M, Budai A, Fox K, Ceremuzynski L. Variations between countries in invasive cardiac procedures and outcomes in patients with suspected unstable angina or myocardialinfraction without initial ST elevation. OASIS (Organisation to Assess Strategies for Ischaemic Syndromes) Registry Investigators. Lancet. 1998;352:507-514. (Pubitemid 28372223)
8. Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP, Van De Werf F, Avezum A, Goodman SG, Flather MD, Fox KA; Global Registry of Acute Coronary Events Investigators. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163:2345-2353. (Pubitemid 37310196)
9. Liistro F, Angioli P, Falsino G, Ducci K, Baldassarre S, Burali A, Bolognese L. Early invasive strategy in elderly pateints with non-ST-elevation acute coronary syndrome: comparison with younger patients regarding 30 day and long term outcome. Heart. 2005;91:1284-1288. (Pubitemid 41360942)
10. Lee PY, Alexander KP, Hammill BG, Pasquali SK, Peterson ED. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA. 2001;286:708-713. (Pubitemid 33010364)
11. Alexander KP, Newby LK, Armstrong PW, Gibler WB, Rich MW, Van de Werf F, White HD, Weaver WD, Naylor MD, Gore JM, Krumholz HM, Ohman EM; American Heart Association Council on Clinical Cardiology; Society of Geriatric Cardiology. Acute coronary care in the elderly, part I. ST segment elevation myocardial infarction. Circulation. 2007;115:2549-2569.
12. Alexander KP, Newby LK, Armstrong PW, Gibler WB, Rich MW, Van de Werf F, White HD, Weaver WD, Naylor MD, Gore JM, Krumholz HM, Ohman EM; American Heart Association Council on Clinical Cardiology; Society of Geriatric Cardiology. Acute coronary care in the elderly, part II. ST segment elevation myocardial infarction. Circulation. 2007;115:2570-2589.
13. Yan RT, Yan AT, Tan M, Chow CM, Fitchert DH, Ervin FL, Cha JYM, Langer A, Goodman SG, for the Canadian Acute Coronary Syndromes Registry Investigators Age-related differences in the management and outcome of patients with acute coronary syndromes. Am Heart J. 2006;151:352-357.
14. Fox KA, Anderson FA Jr, Dabbous OH, Steg PG, López- Sendón J, Van de Werf F, Budaj A, Gurfinkel EP, Goodman SG, Brieger D; GRACE investigators. Intervention in acute coronary syndromes: do patients undergo intervention on the basis of their risk charcateristics? The Global Registry of Acute Coronary Events (GRACE). Heart. 2007;93:177-182. (Pubitemid 46180290)
15. Bach RG, Cannon CP, Weintraub WS, DiBattiste PM, Demopoulos LA, Anderswon HV, DeLucca PT, Mahoney EM, Murphy SA, Braunwald E. The effect of routine, early invasive management on outcome for elderly patients with NSTEMI ACS. Ann Intern Med. 2004;141:186-195.
16. Bauer T, Koeth O, Jünger C, Heer T, Wienbergen H, Gitt A, Zahn R, Senges J, Zeymer U, for the Acute Coronary Syndromes Registry (ACOS) Investigators. Effect of an invasive strategy on in- hospital outcome in elderly patients with non-ST-elevation myocardial infarction. Eur Heart J. 2007;28:2873-2878. (Pubitemid 350233033)
17. Alexander KP, Roe MT, Chen AY, Lytle BL, Pollack CV Jr, Foody JM, Boden WE, Smith SC Jr, Gibler B, Ohman EM, Peterson ED, for the CRUSADE investigators. Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes. JACC. 2005;46:1479-1487.
18. ALKK (Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausä rzte). Zielsetzung der ALKK. http://www.alkk.org.
19. Vogt A, Bonzel T, Harmjanz D, von Leitner ER, Pfafferott C, Engel HJ, Niederer W, Schuster PR, Glunz HG, Neuhaus KL. PTCA registry of German community hospitals. Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte (ALKK) Study Group. Eur Heart J. 1997;18:1110-4.
20. Zeymer U, Zahn R, Hochadel M, Bonzel T, Weber M, Gottwik M, Tebbe U, Senges J. Indications and complications of invasive diagnostic procedures and percutaneous coronary interventions in the year 2003. Results of the quality control registry of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausarzte (ALKK). Z Kardiol. 2005;94:392-8. (Pubitemid 40921967)
21. Zeymer U, Vogt A, Zahn R, Weber MA, Tebbe U, Gottwik M, Bonzel T, Senges J, Neuhaus KL; Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK). Predictors of in-hospital mortality in 1333 patients with acute myocardial infarction complicated by cardiogenic shock treated with primary percutaneous coronary intervention (PCI); Results of the primary PCI registry of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK). Eur Heart J. 2004;25:322-8. (Pubitemid 38295441)
22. De Servi S, Cavallini C, Dellavalle A, Santoro GM, Bonizzoni E, Marzocchi A, Politi A, Pesaresi A, Mariani M, Chierchia S, for the ROSAI-2 Investigators. Non-ST-elevation acute coronary syndrome in the elderly: Treatment strategies and 30-day outcome. Am Heart J. 2004;147:830-836. (Pubitemid 38880993)
23. Muñoz JC, Alonso JJ, Duran JM, Gimeno F, Ramos B, Garcimartin I, de la Fuente L, Gomez I, Fernandez-Aviles F. Coronary stent implantation in patients older than 75 years of age. Am Heart J. 2002;143:620-626.
24. Thompson RC, Holmes DR, Grilli DE, Mock MB, Bailey KR. Changing outcome of angioplasty in the elderly. J Am Coll Cardiol. 1996;27:8-14. (Pubitemid 26018914)
25. Lindsay J, Reddy VM, Pinnow EE, Little T, Pichard AD. Morbidity and mortality rates in elderly patients undergoing percutaneous coronary transluminal angioplasty. Am Heart J. 1994;128:697-702. (Pubitemid 24314657)