Nebulized PPARγ agonists: A novel approach to augment neonatal lung maturation and injury repair in rats

Pediatric Research

Volumn 75, Issue 5, 2014, Pages 631-640

  Morales, Edith ^a,b   Sakurai, Reiko ^a   Husain, Sumair ^a   Paek, Dave ^a   Gong, Ming ^a   Ibe, Basil ^a   Li, Yishi ^a   Husain, Maleha ^a   Torday, John S ^a   Rehan, Virender K ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR MARKER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; ROSIGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SURFACTANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMALE; HYPEROXIA; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MESENCHYME; NEBULIZATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; AGONISTS; ANIMAL; CELL DIFFERENTIATION; CHEMISTRY; GROWTH, DEVELOPMENT AND AGING; INHALATIONAL DRUG ADMINISTRATION; LUNG; LUNG ALVEOLUS; METABOLISM; NEBULIZER; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INHALATION; ANIMALS; ANIMALS, NEWBORN; BRONCHOALVEOLAR LAVAGE; CELL DIFFERENTIATION; FEMALE; HYPEROXIA; LUNG; LUNG INJURY; MALE; NEBULIZERS AND VAPORIZERS; PPAR GAMMA; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; SURFACE-ACTIVE AGENTS; THIAZOLIDINEDIONES;

EID: 84898973018     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2014.8     Document Type: Article

References (26)

1. Torday JS, Torres E, Rehan VK. The role of fibroblast transdifferentiation in lung epithelial cell proliferation, differentiation, and repair in vitro. Pediatr Pathol Mol Med 2003;22:189-207
2. Simon DM, Arikan MC, Srisuma S, et al. Epithelial cell PPAR[gamma] contributes to normal lung maturation. FASEB J 2006;20:1507-9
3. Wang Y, Santos J, Sakurai R, et al. Peroxisome proliferator-Activated receptor gamma agonists enhance lung maturation in a neonatal rat model. Pediatr Res 2009;65:150-5
4. Torday JS, Torday DP, Gutnick J, Qin J, Rehan V. Biologic role of fetal lung fibroblast triglycerides as antioxidants. Pediatr Res 2001;49:843-9
5. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. Effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 1995; 273:413-8
6. Wapner RJ, Sorokin Y, Mele L, et al.; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Long-Term outcomes after repeat doses of antenatal corticosteroids. N Engl J Med 2007;357:1190-8
7. Ballard PL, Ballard RA, Granberg JP, et al. Fetal sex and prenatal betamethasone therapy. J Pediatr 1980;97:451-4
8. Nielsen HC, Torday JS. Sex differences in fetal lung development: Biology, etiology, and evolutionary significance. In: Mendelson CR, ed. Endocrinology of the Lung-Development and Surfactant Synthesis. Totowa, NJ: Humana Press, 2000:141-59
9. Rehan VK, Sakurai R, Corral J, et al. Antenatally administered PPARgamma agonist rosiglitazone prevents hyperoxia-induced neonatal rat lung injury. Am J Physiol Lung Cell Mol Physiol 2010;299:L672-80
10. Dasgupta C, Sakurai R, Wang Y, et al. Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone. Am J Physiol Lung Cell Mol Physiol 2009;296: L1031-41
11. Truong NC, Abbasi A, Sakurai R, Lee WN, Torday JS, Rehan VK. Postnatal rosiglitazone administration to neonatal rat pups does not alter the young adult metabolic phenotype. Neonatology 2012;101:217-24
12. Sierra H, Sakurai R, Lee WN, Truong NC, Torday JS, Rehan VK. Prenatal rosiglitazone administration to neonatal rat pups does not alter the adult metabolic phenotype. PPAR Res 2012;2012:604216
13. Rehan VK, Wang Y, Sugano S, et al. In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. Am J Physiol Lung Cell Mol Physiol 2007;292:L323-33
14. Komajda M, McMurray JJ, Beck-Nielsen H, et al. Heart failure events with rosiglitazone in type 2 diabetes: Data from the RECORD clinical trial. Eur Heart J 2010;31:824-31
15. Leal I, Romio SA, Schuemie M, Oteri A, Sturkenboom M, Trifiro G. Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: A focus on the effects of safety warnings about rosiglitazone. Br J Clin Pharmacol 2013;75:861-8
16. Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356: 2457-71
17. Tolman KG, Freston JW, Kupfer S, Perez A. Liver safety in patients with type 2 diabetes treated with pioglitazone: Results from a 3-year, randomized, comparator-controlled study in the US. Drug Saf 2009;32:787-800
18. Abbas A, Blandon J, Rude J, Elfar A, Mukherjee D. PPAR-? agonist in treatment of diabetes: Cardiovascular safety considerations. Cardiovasc Hematol Agents Med Chem 2012;10:124-34
19. Behrman RE, Butler AS. Preterm Birth: Causes, Consequences, and Prevention. Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes. Washington, DC: National Academies Press, 2007
20. Crane J, Armson A, Brunner M, et al.; Executive Committee of the Society of Obstetricians and Gynaecologists of Canada. Antenatal corticosteroid therapy for fetal maturation. J Obstet Gynaecol Can 2003;25:45-52
21. Genovese T, Cuzzocrea S, Di Paola R, et al. Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. Eur Respir J 2005;25:225-34
22. Liu D, Zeng BX, Zhang SH, Yao SL. Rosiglitazone, an agonist of peroxisome proliferator-Activated receptor gamma, reduces pulmonary inflammatory response in a rat model of endotoxemia. Inflamm Res 2005;54:464-70
23. Grommes J, Morgelin M, Soehnlein O. Pioglitazone attenuates endotoxininduced acute lung injury by reducing neutrophil recruitment. Eur Respir J 2012;40:416-23
24. Torday JS, Rehan VK. Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptin. Am J Physiol Lung Cell Mol Physiol 2002;283:L130-5
25. Ferwana M, Firwana B, Hasan R, et al. Pioglitazone and risk of bladder cancer: A meta-Analysis of controlled studies. Diabet Med 2013;30:1026-32
26. Rehan VK, Sakurai R, Li Y, et al. Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model. Pediatr Pulmonol 2012;47:162-71