Peroxisome proliferator-activated receptor γ agonists enhance lung maturation in a neonatal rat model

Pediatric Research

Volumn 65, Issue 2, 2009, Pages 150-155

  Wang, Ying ^a   Santos, Jamie ^a   Sakurai, Reiko ^a   Shin, Eugene ^a   Cerny, Laura ^a   Torday, John S ^a   Rehan, Virender K ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; ELECTROLYTE; GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROSTAGLANDIN J2; ROSIGLITAZONE; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C; TRIACYLGLYCEROL; TROPONIN I;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD GAS ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; ELECTROLYTE BLOOD LEVEL; FETUS LUNG MATURATION; GLUCOSE BLOOD LEVEL; LUNG ALVEOLUS EPITHELIUM; LUNG BLOOD VESSEL; MORPHOMETRICS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPRAGUE DAWLEY RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; BLOOD GAS ANALYSIS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EPITHELIAL CELLS; INJECTIONS, INTRAPERITONEAL; KIDNEY; LIVER; LUNG; MEMBRANE PROTEINS; MESODERM; MODELS, ANIMAL; PPAR GAMMA; PROSTAGLANDIN D2; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY SYSTEM AGENTS; THIAZOLIDINEDIONES; TIME FACTORS;

EID: 60449109043     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181938c40     Document Type: Article

References (27)

1. Tontonoz P, Hu E, Spiegelman BM 1995 Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma. Curr Opin Genet Dev 5:571-576
2. Chen H, Jackson S, Doro M, McGowan S 1998 Perinatal expression of genes that may participate in lipid metabolism by lipid-laden lung fibroblasts. J Lipid Res 39:2483-2492
3. Torday JS, Torres E, Rehan VK 2003 The role of fibroblast transdifferentiation in lung epithelial cell proliferation, differentiation, and repair in vitro. Pediatr Pathol Mol Med 22:189-207
4. Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Tsai LW, Ingenito EP, Gonzalez F, Shapiro SD, Mariani TJ 2006 Epithelial cell PPAR[gamma] contributes to normal lung maturation. FASEB J 20:1507-1509
5. 1995 Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. JAMA 273:413-418
6. Wapner RJ, Sorokin Y, Mele L, Johnson F, Dudley DJ, Spong CY, Peaceman AM, Leveno KJ, Malone F, Caritis SN, Mercer B, Harper M, Rouse DJ, Thorp JM, Ramin S, Carpenter MW, Gabbe SG; National Institute of Child Health and Human Development Maternal-Fetal Medicine Unite Network 2007 Long-term outcomes after repeat doses of antenatal corticosteroids. N Engl J Med 357:1190-1198
7. Ballard PL, Ballard RA, Granberg JP, Sniderman S, Gluckman PD, Kaplan SL, Grumbach MM 1980 Fetal sex and prenatal betamethasone therapy. J Pediatr 97:451-454
8. Nielson HC, Torday JS 2000 Sex differences in fetal lung development: Biology, Etiology, and Evolutionary Significance. In: Mendelson CR (ed) Endocrinology of the Lung-Development and Surfactant Synthesis. Totowa, New Jersey: Humana Press, pp 141-159
9. Willet KE, Jobe AH, Ikegami M, Newnham J, Sly PD 2000 Antenatal retinioic acid does not alter alveolization or postnatal lung function in preterm sheep. Eur Respir J 16:101-107
10. Srinivasan G, Brace EN, Houtz PK, Brace MC 2002 Dexamethasone-induced changes in lung function are not prevented by concomitant treatment with retinoic acid. Am J Physiol Lung Cell Mol Physiol 283:L275-L287
11. Rehan VK, Wang Y, Sugano S, Santos J, Patel S, Sakurai R, Boros LG, Lee WP, Torday JS 2007 In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism. Am J Physiol Lung Cell Mol Physiol 292:L323-L333
12. Randell SH, Mercer RR, Young SL 1989 Postnatal growth of pulmonary acini and alveoli in normal and oxygen-exposed rats studied by serial section reconstructions. Am J Anat 186:55-68
13. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A 1996 Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439
14. Massaro D, Massaro GD 1986 Dexamethasone accelerates postnatal alveolar wall thinning and alters wall composition. Am J Physiol 251:R218-R224
15. Massaro D, Teich N, Maxwell S, Massaro GD, Whitney P 1985 Postnatal development of alveoli. Regulation and evidence for a critical period in rats. J Clin Invest 76:1297-1305
16. Cerny L, Torday JS, Rehan VK 2008 Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook. Lung 186:75-89
17. Heikkinen S, Auwerx J, Argmann CA 2007 PPARgamma in human and mouse physiology. Biochim Biophys Acta 1771:999-1013
18. Rehan VK, Sugano S, Wang Y, Santos J, Romero S, Dasgupta C, Keane MP, Stahlman MT, Torday JS 2006 Evidence for the presence of lipofibroblasts in human lung. Exp Lung Res 32:379-393
19. Torday JS, Rehan VK 2007 Developmental cell/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasia. Pediatr Res 62:2-7
20. Standiford TJ, Keshamouni VG, Reddy RC 2005 Peroxisome proliferator-activated receptor-(gamma) as a regulator of lung inflammation and repair. Proc Am Thorac Soc 2:226-231
21. Torday JS, Rehan VK 2002 Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptin. Am J Physiol Lung Cell Mol Physiol 283:L130-L135
22. Liu D, Zeng BX, Zhang SH, Yao SL 2005 Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces pulmonary inflammatory response in a rat model of endotoxemia. Inflamm Res 54:464-470
23. Rehan VK, Wang Y, Patel S, Santos J, Torday JS 2006 Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, prevents hyperoxia-induced neonatal rat lung injury in vivo. Pediatr Pulmonol 41:558-569
24. Wayman NS, Hattori Y, McDonald MC, Mota-Filipe H, Cuzzocrea S, Pisano B, Chatterjee PK, Thiemermann C 2002 Ligands of the peroxisome proliferator- activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB J 16:1027-1040
25. Genovese T, Cuzzocrea S, Di Paola R, Mazzon E, Mastrazzo C, Catalano P, Sortino M, Crimi N, Caputi AP, Thiemermann C, Vancheri C 2005 Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. Eur Respir J 25:225-234
26. Khan MA, St Peter JV, Xue JL 2002 A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone. Diabetes Care 25:708-711
27. Home PD, Pocock SJ, Beck-Nielsen H, Gomis R, Hanefeld M, Jones NP, Komajda M, McMurray JJ 2007 Rosiglitazone evaluated for cardiovascular outcomes-an interim analysis. N Engl J Med 357:28-38