Insulin-derived amyloidosis and poor glycemic control: A case series

American Journal of Medicine

Volumn 127, Issue 5, 2014, Pages 450-454

  Nagase, Terumasa ^a   Iwaya, Keiichi ^b   Iwaki, Yoshiki ^a   Kotake, Fumio ^a   Uchida, Ryuji ^a   Oh I, Tsunao ^a   Sekine, Hidenori ^a   Miwa, Kazuhiro ^a   Murakami, Satoshi ^a   Odaka, Tomotada ^a   Kure, Masahiko ^a   Nemoto, Yoko ^a   Noritake, Masayuki ^a   Katsura, Yoshiya ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Amyloidosis; Insulin absorption; Insulin dose; Insulin therapy

Indexed keywords

AMYLOIDOSIS; INSULIN ABSORPTION; INSULIN DOSE; INSULIN THERAPY;

ABSORPTION; ADULT; AGED; AGED, 80 AND OVER; AMYLOIDOSIS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; JAPAN; MALE; MIDDLE AGED;

EID: 84898960027     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2013.10.029     Document Type: Article

References (13)

1. F.E. Dische, C. Wernstedt, and G.T. Westermark et al. Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient Diabetologia 31 1988 158 161
2. T. Nagase, Y. Katsura, and Y. Iwaki et al. The insulin ball Lancet 373 2009 184
3. B. Swift Examination of insulin injection sites: an unexpected finding of localized amyloidosis Diabet Med 19 2002 881 882
4. S. Yumlu, R. Barany, M. Eriksson, and C. Röcken Localized insulin-derived amyloidosis in patients with diabetes mellitus: a case report Hum Pathol 40 2009 1655 1660
5. A.A. Lonsdale-Eccles, P. Gonda, J.A. Gilbertson, and A.E. Haworth Localized cutaneous amyloid at an insulin injection site Clin Exp Dermatol 34 2009 1027 1028
6. Y. Shikama, J. Kitazawa, and N. Yagihashi et al. Localized amyloidosis at the site of repeated insulin injection in a diabetic patient Intern Med 49 2010 397 401
7. M.P.S. Sie, H.E. van der Wiel, F.M.M. Smedts, and A.C. de Boer Human recombinant insulin and amyloidosis: an unexpected association Neth J Med 68 2010 138 140
8. J.O. Endo, C. Röcken, and S. Lamb et al. Nodular amyloidosis in a diabetic patient with frequent hypoglycemia: sequelae of repeatedly injecting insulin without site rotation J Am Acad Dermatol 63 2010 e113 e114
9. A. Kashiwagi, M. Kasuga, and E. Araki et al. International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values Diabetol Int 3 2012 8 10
10. U.B. Johansson, S. Amsberg, and L. Hannerz et al. Impaired absorption of insulin aspart from lipohypertrophic injection sites Diabetes Care 28 2005 2025 2027
11. G. Merlini, and V. Bellotti Molecular mechanisms of amyloidosis N Engl J Med 349 2003 583 596
12. S. Störkel, H.M. Schneider, H. Müntefering, and S. Kashiwagi Iatrogenic, insulin-dependent, local amyloidosis Lab Invest 48 1983 108 111
13. T. Zako, M. Sakono, and N. Hashimoto et al. Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrils Biophys J 96 2009 3331 3340