Most blood biomarkers related to vitamin status, one-carbon metabolism, and the kynurenine pathway show adequate preanalytical stability and within-person reproducibility to allow assessment of exposure or nutritional status in healthy women and cardiovascular patients

Journal of Nutrition

Volumn 144, Issue 5, 2014, Pages 784-790

  Midttun, Øivind ^a   Townsend, Mary K ^b   Nygård, Ottar ^c,d   Tworoger, Shelley S ^b,e   Brennan, Paul ^f   Johansson, Mattias ^f   Ueland, Per Magne ^c,d  

^a Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School ^*

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF BERGEN   (Norway)

^d HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHOLINE; DIMETHYLGLYCINE; EDETIC ACID; HEPARIN; HOMOCYSTEINE; KYNURENINE;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CARBON METABOLISM; CARDIAC PATIENT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; ONE CARBON METABOLISM; POSTMENOPAUSE; REPRODUCIBILITY; STABLE ANGINA PECTORIS;

ADULT; AGED; BIOLOGICAL MARKERS; BLOOD SPECIMEN COLLECTION; CARBON; CHEMISTRY, CLINICAL; CORONARY ARTERY DISEASE; DOUBLE-BLIND METHOD; EDETIC ACID; FEMALE; HEPARIN; HUMANS; KYNURENINE; MALE; MIDDLE AGED; NUTRITIONAL STATUS; POSTMENOPAUSE; REPRODUCIBILITY OF RESULTS; VITAMINS; YOUNG ADULT;

EID: 84898920468     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.189738     Document Type: Article

References (39)

1. KussmannM, Affolter M, Nagy K, Holst B, Fay LB. Mass spectrometry in nutrition: understanding dietary health effects at the molecular level. Mass Spectrom Rev. 2007;26:727-50.
2. Ueland PM, Midttun O, Windelberg A, Svardal A, Skalevik R, Hustad S. Quantitative profiling of folate and one-carbon metabolism in largescale epidemiological studies by mass spectrometry. Clin Chem Lab Med. 2007;45:1737-45.
3. Kushnir MM, Rockwood AL, Bergquist J. Liquid chromatographytandem mass spectrometry applications in endocrinology. Mass Spectrom Rev. 2010;29:480-502.
4. Rosner B. One-way ANOVA-the random-effects model. Fundamentals of biostatistics. Belmont, CA: Duxbury; 2006;613-8.
5. Elliott P, Peakman TC, Biobank UK. The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine. Int J Epidemiol. 2008;37:234-44.
6. Jackson C, Best N, Elliott P. UK Biobank Pilot Study: stability of haematological and clinical chemistry analytes. Int J Epidemiol. 2008;37(Suppl 1):i16-22.
7. Colditz GA, Manson JE, Hankinson SE. The Nurses' Health Study: 20-year contribution to the understanding of health among women. J Womens Health. 1997;6:49-62.
8. Kotsopoulos J, Tworoger SS, Campos H, Chung FL, Clevenger CV, Franke AA, Mantzoros CS, Ricchiuti V, Willett WC, Hankinson SE, et al. Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies. Cancer Epidemiol Biomarkers Prev. 2010;19:938-46.
9. Ebbing M, Bleie O, Ueland PM, Nordrehaug JE, Nilsen DW, Vollset SE, Refsum H, Pedersen EK, Nygard O. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA. 2008; 300:795-804.
10. Midttun Ø, Hustad S, Ueland PM. Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2009;23:1371-9.
11. Midttun Ø, Kvalheim G, Ueland PM. High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS/MS. Anal Bioanal Chem. 2013;405:2009-17.
12. Midttun Ø, Ueland PM. Determination of vitamins A, D and E in a small volume of human plasma by a high-throughput method based on liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2011;25:1942-8.
13. Windelberg A, Arseth O, Kvalheim G, Ueland PM. Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin Chem. 2005;51:2103-9.
14. Kelleher BP, Broin SD. Microbiological assay for vitamin B12 performed in 96-well microtitre plates. J Clin Pathol. 1991;44:592-5.
15. Molloy AM, Scott JM. Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Methods Enzymol. 1997;281:43-53.
16. FOCUS. Guidance document on estimating persistence and degradation kinetics from environmental fate studies on pesticides in EU registration. Report of the FOCUS work group on degradation kinetics. 2006. Available from: http://focus.jrc.ec. europa.eu/dk.
17. Bartko JJ. Measurement and reliability: statistical thinking considerations. Schizophr Bull. 1991;17:483-9.
18. Team RDC. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2008.
19. Hankinson SE, London SJ, Chute CG, Barbieri RL, Jones L, Kaplan LA, Sacks FM, Stampfer MJ. Effect of transport conditions on the stability of biochemical markers in blood. Clin Chem. 1989;35:2313-6.
20. Fiskerstrand T, Refsum H, Kvalheim G, Ueland PM. Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clin Chem. 1993;39:263-71.
21. Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem. 2003;49:286-94.
22. Anthes JC, Eckel S, Siegel MI, Egan RW, Billah MM. Phospholipase D in homogenates from HL-60 granulocytes: implications of calcium and G protein control. Biochem Biophys Res Commun. 1989;163:657-64.
23. Solomon LR. Considerations in the use of B6 vitamers in hematologic disorders: I. Red cell transport and metabolism of pyridoxal. Blood. 1982;59:495-501.
24. Darlington LG, Forrest CM, Mackay GM, Smith RA, Smith AJ, Stoy N, Stone TW. On the biological importance of the 3-hydroxyanthranilic acid:anthranilic acid ratio. Int J Tryptophan Res. 2010;3:51-9.
25. Hustad S, Eussen S, Midttun O, Ulvik A, van de Kant PM, Morkrid L, Gislefoss R, Ueland PM. Kinetic modeling of storage effects on biomarkers related to B vitamin status and one-carbon metabolism. Clin Chem. 2012;58:402-10.
26. Hannisdal R, Ueland PM, Eussen SJ, Svardal A, Hustad S. Analytical recovery of folate degradation products formed in human serum and plasma at room temperature. J Nutr. 2009;139:1415-8.
27. Velzing-Aarts FV, Holm PI, Fokkema MR, vanderDijs FP, Ueland PM, Muskiet FA. Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy. Am J Clin Nutr. 2005;81:1383-9.
28. Blackwell S. The biochemistry, measurement and current clinical significance of asymmetric dimethylarginine. Ann Clin Biochem. 2010;47:17-28.
29. Vanholder R, Eloot S, Schepers E, Neirynck N, Glorieux G, Massy Z. An obituary for GFR as the main marker for kidney function? Semin Dial. 2012;25:9-14.
30. Lewerin C, Ljungman S, Nilsson-Ehle H. Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly. J Intern Med. 2007;261:65-73.
31. Frick B, Schroecksnadel K, Neurauter G, Leblhuber F, Fuchs D. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem. 2004;37:684-7.
32. Sulo G, Vollset SE, Nygard O, Midttun O, Ueland PM, Eussen SJ, Pedersen ER, Tell GS. Neopterin and kynurenine-tryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study. Int J Cardiol. 2013;168:1435-40.
33. Konstantinova SV, Tell GS, Vollset SE, Nygard O, Bleie O, Ueland PM. Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr. 2008;138:914-20.
34. Svingen GFT, Ueland PM, Pedersen EKR, Schartum-Hansen H, Seifert R, Ebbing M, Løland KH, Tell GS, Nygård O. Plasma dimethylglycine and risk of incident acute myocardial infarction in patients with stable angina pectoris. Arterioscler Thromb Vasc Biol. 2013;33:2041-8.
35. Floegel A, Drogan D, Wang-Sattler R, Prehn C, Illig T, Adamski J, Joost H-G, Boeing H, Pischon T. Reliability of serum metabolite concentrations over a 4-month period using a targeted metabolomic approach. PLoS One. 2011;6:e21103.
36. Garg UC, Zheng ZJ, Folsom AR, Moyer YS, Tsai MY, Mcgovern P, Eckfeldt JH. Short-term and long-term variability of plasma homocysteine measurement. Clin Chem. 1997;43:141-5.
37. Leenders M, Ros MM, Sluijs I, Boshuizen HC, van Gils CH, Jansen EHJM, Bueno-de-Mesquita HB. Reliability of selected antioxidants and compounds involved in one-carbon metabolism in two dutch cohorts. Nutr Cancer. 2013;65:17-24.
38. Cope EL, Shrubsole MJ, Cohen SS, Cai Q, Wu J, Ueland PM, Midttun O, Sonderman JS, Blot WJ, Signorello LB. Intra-individual variation in one-carbon metabolism plasma biomarkers. Cancer Epidemiol Biomarkers Prev. 2013;22:1894-9.
39. Berglund L. Regression dilution bias: tools for correction methods and sample size calculation. Ups J Med Sci. 2012;117:279-83.