메뉴 건너뛰기




Volumn 60, Issue 1, 2014, Pages 23-31

Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification

Author keywords

Antibodies; B cells; Cell differentiation; Gene regulation; Transcription factors

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CALCIUM ION; CALMODULIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN HEAVY CHAIN; MESSENGER RNA; MYC PROTEIN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR E2A; URACIL; URACIL DNA GLYCOSIDASE;

EID: 84898920232     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2014.03.011     Document Type: Article
Times cited : (4)

References (52)
  • 1
    • 67349172695 scopus 로고    scopus 로고
    • Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression
    • Aas P.A., Pena-Diaz J., Liabakk N.B., Krokan H.E., Skorpen F. Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression. DNA Repair (Amst) 2009, 8:822-833.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 822-833
    • Aas, P.A.1    Pena-Diaz, J.2    Liabakk, N.B.3    Krokan, H.E.4    Skorpen, F.5
  • 2
    • 27844591343 scopus 로고    scopus 로고
    • Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice
    • Andersen S., Ericsson M., Dai H.Y., Pena-Diaz J., Slupphaug G., Nilsen H., Aarset H., Krokan H.E. Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice. DNA Repair (Amst) 2005, 4:1432-1441.
    • (2005) DNA Repair (Amst) , vol.4 , pp. 1432-1441
    • Andersen, S.1    Ericsson, M.2    Dai, H.Y.3    Pena-Diaz, J.4    Slupphaug, G.5    Nilsen, H.6    Aarset, H.7    Krokan, H.E.8
  • 4
    • 70350462285 scopus 로고    scopus 로고
    • Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
    • Beck K., Peak M.M., Ota T., Nemazee D., Murre C. Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci. J. Exp. Med. 2009, 206:2271-2284.
    • (2009) J. Exp. Med. , vol.206 , pp. 2271-2284
    • Beck, K.1    Peak, M.M.2    Ota, T.3    Nemazee, D.4    Murre, C.5
  • 5
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter R., Pham P., Scharff M.D., Goodman M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:4102-4107.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 6
    • 30944469861 scopus 로고    scopus 로고
    • The chicken Ig light chain 3'-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A
    • Conlon T.M., Meyer K.B. The chicken Ig light chain 3'-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A. Eur. J. Immunol. 2006, 36:139-148.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 139-148
    • Conlon, T.M.1    Meyer, K.B.2
  • 8
    • 1542329612 scopus 로고    scopus 로고
    • Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB
    • Dedeoglu F., Horwitz B., Chaudhuri J., Alt F.W., Geha R.S. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int. Immunol. 2004, 16:395-404.
    • (2004) Int. Immunol. , vol.16 , pp. 395-404
    • Dedeoglu, F.1    Horwitz, B.2    Chaudhuri, J.3    Alt, F.W.4    Geha, R.S.5
  • 9
    • 34249790004 scopus 로고    scopus 로고
    • Molecular mechanisms of antibody somatic hypermutation
    • Di Noia J.M., Neuberger M.S. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 2007, 76:1-22.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 1-22
    • Di Noia, J.M.1    Neuberger, M.S.2
  • 10
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson S.K., Market E., Besmer E., Papavasiliou F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 2003, 197:1291-1296.
    • (2003) J. Exp. Med. , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 13
    • 0037069382 scopus 로고    scopus 로고
    • Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system
    • Greenbaum S., Zhuang Y. Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:15030-15035.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 15030-15035
    • Greenbaum, S.1    Zhuang, Y.2
  • 15
    • 0032520689 scopus 로고    scopus 로고
    • Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase
    • Haug T., Skorpen F., Aas P.A., Malm V., Skjelbred C., Krokan H.E. Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase. Nucleic Acids Res. 1998, 26:1449-1457.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1449-1457
    • Haug, T.1    Skorpen, F.2    Aas, P.A.3    Malm, V.4    Skjelbred, C.5    Krokan, H.E.6
  • 16
    • 84896505043 scopus 로고    scopus 로고
    • Allelic Exclusion of IgH through Inhibition of E2A in a VDJ Recombination Complex
    • Hauser J., Grundström C., Grundström T. Allelic Exclusion of IgH through Inhibition of E2A in a VDJ Recombination Complex. J. Immunol. 2014, 192:2460-2470.
    • (2014) J. Immunol. , vol.192 , pp. 2460-2470
    • Hauser, J.1    Grundström, C.2    Grundström, T.3
  • 18
    • 70249148999 scopus 로고    scopus 로고
    • Initiation of antigen receptor-dependent differentiation into plasma cells by calmodulin inhibition of E2A
    • Hauser J., Verma-Gaur J., Wallenius A., Grundström T. Initiation of antigen receptor-dependent differentiation into plasma cells by calmodulin inhibition of E2A. J. Immunol. 2009, 183:1179-1187.
    • (2009) J. Immunol. , vol.183 , pp. 1179-1187
    • Hauser, J.1    Verma-Gaur, J.2    Wallenius, A.3    Grundström, T.4
  • 19
    • 74449083836 scopus 로고    scopus 로고
    • Calmodulin inhibition of E2A stops expression of surrogate light chains of the pre-B-cell receptor and CD19
    • Hauser J., Wallenius A., Sveshnikova N., Saarikettu J., Grundström T. Calmodulin inhibition of E2A stops expression of surrogate light chains of the pre-B-cell receptor and CD19. Mol. Immunol. 2010, 47:1031-1038.
    • (2010) Mol. Immunol. , vol.47 , pp. 1031-1038
    • Hauser, J.1    Wallenius, A.2    Sveshnikova, N.3    Saarikettu, J.4    Grundström, T.5
  • 20
    • 0030037519 scopus 로고    scopus 로고
    • B cell differentiation and isotype switching is related to division cycle number
    • Hodgkin P.D., Lee J.H., Lyons A.B. B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 1996, 184:277-281.
    • (1996) J. Exp. Med. , vol.184 , pp. 277-281
    • Hodgkin, P.D.1    Lee, J.H.2    Lyons, A.B.3
  • 22
    • 22344453737 scopus 로고    scopus 로고
    • B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil
    • Kavli B., Andersen S., Otterlei M., Liabakk N.B., Imai K., Fischer A., Durandy A., Krokan H.E., Slupphaug G. B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil. J. Exp. Med. 2005, 201:2011-2021.
    • (2005) J. Exp. Med. , vol.201 , pp. 2011-2021
    • Kavli, B.1    Andersen, S.2    Otterlei, M.3    Liabakk, N.B.4    Imai, K.5    Fischer, A.6    Durandy, A.7    Krokan, H.E.8    Slupphaug, G.9
  • 24
    • 0030754089 scopus 로고    scopus 로고
    • Differential interactions of Id proteins with basic-helix-loop-helix transcription factors
    • Langlands K., Yin X., Anand G., Prochownik E.V. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. 1997, 272:19785-19793.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19785-19793
    • Langlands, K.1    Yin, X.2    Anand, G.3    Prochownik, E.V.4
  • 25
    • 19544365049 scopus 로고    scopus 로고
    • New insights into E-protein function in lymphocyte development
    • Lazorchak A., Jones M.E., Zhuang Y. New insights into E-protein function in lymphocyte development. Trends Immunol. 2005, 26:334-338.
    • (2005) Trends Immunol. , vol.26 , pp. 334-338
    • Lazorchak, A.1    Jones, M.E.2    Zhuang, Y.3
  • 28
    • 0041931059 scopus 로고    scopus 로고
    • The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription
    • Michael N., Shen H.M., Longerich S., Kim N., Longacre A., Storb U. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Immunity 2003, 19:235-242.
    • (2003) Immunity , vol.19 , pp. 235-242
    • Michael, N.1    Shen, H.M.2    Longerich, S.3    Kim, N.4    Longacre, A.5    Storb, U.6
  • 29
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 30
    • 0033603340 scopus 로고    scopus 로고
    • Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
    • Muramatsu M., Sankaranand V.S., Anant S., Sugai M., Kinoshita K., Davidson N.O., Honjo T. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 1999, 274:18470-18476.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18470-18476
    • Muramatsu, M.1    Sankaranand, V.S.2    Anant, S.3    Sugai, M.4    Kinoshita, K.5    Davidson, N.O.6    Honjo, T.7
  • 31
    • 84934443557 scopus 로고    scopus 로고
    • Regulation and function of the E2A proteins in B cell development
    • Murre C. Regulation and function of the E2A proteins in B cell development. Adv. Exp. Med. Biol. 2007, 596:1-7.
    • (2007) Adv. Exp. Med. Biol. , vol.596 , pp. 1-7
    • Murre, C.1
  • 32
    • 0030841051 scopus 로고    scopus 로고
    • Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene
    • Nilsen H., Otterlei M., Haug T., Solum K., Nagelhus T.A., Skorpen F., Krokan H.E. Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Res. 1997, 25:750-755.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 750-755
    • Nilsen, H.1    Otterlei, M.2    Haug, T.3    Solum, K.4    Nagelhus, T.A.5    Skorpen, F.6    Krokan, H.E.7
  • 35
    • 0032766646 scopus 로고    scopus 로고
    • Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene
    • Pan L., Sato S., Frederick J.P., Sun X.H., Zhuang Y. Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. Mol. Cell. Biol. 1999, 19:5969-5980.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5969-5980
    • Pan, L.1    Sato, S.2    Frederick, J.P.3    Sun, X.H.4    Zhuang, Y.5
  • 36
    • 84860510016 scopus 로고    scopus 로고
    • Mammalian mismatch repair: error-free or error-prone?
    • Pena-Diaz J., Jiricny J. Mammalian mismatch repair: error-free or error-prone?. Trends Biochem. Sci. 2012, 37:206-214.
    • (2012) Trends Biochem. Sci. , vol.37 , pp. 206-214
    • Pena-Diaz, J.1    Jiricny, J.2
  • 37
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada C., Williams G.T., Nilsen H., Barnes D.E., Lindahl T., Neuberger M.S. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 2002, 12:1748-1755.
    • (2002) Curr. Biol. , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 38
  • 39
    • 4644369697 scopus 로고    scopus 로고
    • Calcium/calmodulin inhibition of transcriptional activity of E-proteins by prevention of their binding to DNA
    • Saarikettu J., Sveshnikova N., Grundström T. Calcium/calmodulin inhibition of transcriptional activity of E-proteins by prevention of their binding to DNA. J. Biol. Chem. 2004, 279:41004-41011.
    • (2004) J. Biol. Chem. , vol.279 , pp. 41004-41011
    • Saarikettu, J.1    Sveshnikova, N.2    Grundström, T.3
  • 40
    • 84865155904 scopus 로고    scopus 로고
    • Does DNA repair occur during somatic hypermutation?
    • Saribasak H., Gearhart P.J. Does DNA repair occur during somatic hypermutation?. Semin. Immunol. 2012, 24:287-292.
    • (2012) Semin. Immunol. , vol.24 , pp. 287-292
    • Saribasak, H.1    Gearhart, P.J.2
  • 41
    • 0038515309 scopus 로고    scopus 로고
    • E-proteins directly regulate expression of activation-induced deaminase in mature B cells
    • Sayegh C.E., Quong M.W., Agata Y., Murre C. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat. Immunol. 2003, 4:586-593.
    • (2003) Nat. Immunol. , vol.4 , pp. 586-593
    • Sayegh, C.E.1    Quong, M.W.2    Agata, Y.3    Murre, C.4
  • 43
    • 36549008815 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair
    • Schrader C.E., Guikema J.E., Linehan E.K., Selsing E., Stavnezer J. Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. J. Immunol. 2007, 179:6064-6071.
    • (2007) J. Immunol. , vol.179 , pp. 6064-6071
    • Schrader, C.E.1    Guikema, J.E.2    Linehan, E.K.3    Selsing, E.4    Stavnezer, J.5
  • 44
    • 84863806091 scopus 로고    scopus 로고
    • Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase
    • Sharbeen G., Yee C.W., Smith A.L., Jolly C.J. Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. J. Exp. Med. 2012, 209:965-974.
    • (2012) J. Exp. Med. , vol.209 , pp. 965-974
    • Sharbeen, G.1    Yee, C.W.2    Smith, A.L.3    Jolly, C.J.4
  • 46
    • 0028933306 scopus 로고
    • Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase
    • Slupphaug G., Eftedal I., Kavli B., Bharati S., Helle N.M., Haug T., Levine D.W., Krokan H.E. Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase. Biochemistry 1995, 34:128-138.
    • (1995) Biochemistry , vol.34 , pp. 128-138
    • Slupphaug, G.1    Eftedal, I.2    Kavli, B.3    Bharati, S.4    Helle, N.M.5    Haug, T.6    Levine, D.W.7    Krokan, H.E.8
  • 47
    • 78149264026 scopus 로고    scopus 로고
    • Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching
    • Stavnezer J., Björkman A., Du L., Cagigi A., Pan-Hammarström Q. Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching. Adv. Immunol. 2010, 108:45-109.
    • (2010) Adv. Immunol. , vol.108 , pp. 45-109
    • Stavnezer, J.1    Björkman, A.2    Du, L.3    Cagigi, A.4    Pan-Hammarström, Q.5
  • 49
  • 51
    • 59849120878 scopus 로고    scopus 로고
    • E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification
    • Yabuki M., Ordinario E.C., Cummings W.J., Fujii M.M., Maizels N. E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J. Immunol. 2009, 182:408-415.
    • (2009) J. Immunol. , vol.182 , pp. 408-415
    • Yabuki, M.1    Ordinario, E.C.2    Cummings, W.J.3    Fujii, M.M.4    Maizels, N.5
  • 52
    • 0028148938 scopus 로고
    • The helix-loop-helix gene E2A is required for B cell formation
    • Zhuang Y., Soriano P., Weintraub H. The helix-loop-helix gene E2A is required for B cell formation. Cell 1994, 79:875-884.
    • (1994) Cell , vol.79 , pp. 875-884
    • Zhuang, Y.1    Soriano, P.2    Weintraub, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.