Elevated plasma retinol-binding protein 4 is associated with increased risk of type 2 diabetes in middle-aged and elderly Chinese adults

Journal of Nutrition

Volumn 144, Issue 5, 2014, Pages 722-728

  Sun, Liang ^a,b   Qi, Qibin ^c   Zong, Geng ^a,b   Ye, Xingwang ^a,b   Li, Huaixing ^a,b   Liu, Xin ^a,b   Zheng, He ^a,b   Hu, Frank B ^d   Liu, Yong ^a,b   Lin, Xu ^a,b  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ANTIDIABETIC AGENT; C REACTIVE PROTEIN; CREATININE; FATTY ACID; FERRITIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEME; IRON; LIPID; RETINOL BINDING PROTEIN 4;

ADULT; AGED; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHINESE; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; DISEASE ASSOCIATION; ERYTHROCYTE; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN RESISTANCE; IRON INTAKE; KIDNEY FUNCTION; LIFESTYLE; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; RISK ASSESSMENT; RISK FACTOR; SELF REPORT;

ADIPOKINES; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FOOD HABITS; HUMANS; HYPERTENSION; INCIDENCE; INFLAMMATION; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; RETINOL-BINDING PROTEINS, PLASMA; RISK FACTORS;

EID: 84898908162     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.189860     Document Type: Article

References (44)

1. Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H, Ji Q, et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010;362:1090-101.
2. Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, Hu FB. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA. 2009;301:2129-40.
3. Li S, Shin HJ, Ding EL, van Dam RM. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2009;302:179-88.
4. Sun Q, van Dam RM, Meigs JB, Franco OH, Mantzoros CS, Hu FB. Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study. Diabetes. 2010;59:611-8.
5. Blaner WS. Retinol-binding protein: the serum transport protein for vitamin A. Endocr Rev. 1989;10:308-16.
6. Tsutsumi C, Okuno M, Tannous L, Piantedosi R, Allan M, Goodman DS, Blaner WS. Retinoids and retinoid-binding protein expression in rat adipocytes. J Biol Chem. 1992;267:1805-10.
7. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356-62.
8. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006;354:2552-63.
9. Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu FB, Franco OH, Wang J, Li H, Liu Y, et al. Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab. 2007;92:4827-34.
10. Sun Q, Kiernan UA, Shi L, Phillips DA, Kahn BB, Hu FB, Manson JE, Albert CM, Rexrode KM. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study. Circulation. 2013;127:1938-47.
11. Erikstrup C, Mortensen OH, Pedersen BK. Retinol-binding protein 4 and insulin resistance. N Engl J Med. 2006;355:1393-4, author reply 1394-5.
12. Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH, Lee HK, Park KS. Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care. 2006;29:2457-61.
13. Xu M, Li XY, Wang JG, Wang XJ, Huang Y, Cheng Q, Huang HE, Li R, Xiang J, Tan JR, et al. Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population. Diabetologia. 2009;52:1511-9.
14. Takebayashi K, Suetsugu M, Wakabayashi S, Aso Y, Inukai T. Retinol binding protein-4 levels and clinical features of type 2 diabetes patients. J Clin Endocrinol Metab. 2007;92:2712-9.
15. Kaess BM, Enserro DM, McManus DD, Xanthakis V, Chen MH, Sullivan LM, Ingram C, O'Donnell CJ, Keaney JF, Vasan RS, et al. Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study. J Clin Endocrinol Metab. 2012;97:E1943-7.
16. Shaker O, El-Shehaby A, Zakaria A, Mostafa N, Talaat S, Katsiki N, Mikhailidis DP. Plasma visfatin and retinol binding protein-4 levels in patients with type 2 diabetes mellitus and their relationship to adiposity and fatty liver. Clin Biochem. 2011;44:1457-63.
17. Fernández-Real JM, Moreno JM, Ricart W. Circulating retinol-binding protein-4 concentration might reflect insulin resistance-associated iron overload. Diabetes. 2008;57:1918-25.
18. Ye X, Yu Z, Li H, Franco OH, Liu Y, Lin X. Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J Am Coll Cardiol. 2007;49:1798-805.
19. Sun L, Franco OH, Hu FB, Cai L, Yu Z, Li H, Ye X, Qi Q, Wang J, Pan A, et al. Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly Chinese. J Clin Endocrinol Metab. 2008;93:4690-6.
20. Yang Y. Chinese food composition table 2004. Beijing, China: Peking University Medical Press; 2005.
21. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol. 1986;124:17-27.
22. Zong G, Zhu J, Sun L, Ye X, Jin Q, Zheng H, Yu Z, Li H, Sun Q, Lin X. Associations of fatty acids in the de novo lipogenesis pathway with risk of metabolic syndrome in middle-aged and older Chinese. Am J Clin Nutr. 2013;98:319-26.
23. Skov T, Deddens J, Petersen MR, Endahl L. Prevalence proportion ratios: estimation and hypothesis testing. Int J Epidemiol. 1998;27: 91-5.
24. Kanai M, Raz A, Goodman DS. Retinol-binding protein: the transport protein for vitamin A in human plasma. J Clin Invest. 1968;47: 2025-44.
25. Mercader J, Granados N, Caimari A, Oliver P, Bonet ML, Palou A. Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models. Horm Metab Res. 2008;40:467-72.
26. Meisinger C, Ruckert IM, Rathmann W, Doring A, Thorand B, Huth C, Kowall B, Koenig W. Retinol-binding protein 4 is associated with prediabetes in adults from the general population: the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study. Diabetes Care. 2011;34:1648-50.
27. Rhee EJ, Seo MH, Jeon WS, Won HK, Choi JH, Park SE, Park CY, Kwag HJ, Oh KW, Park SW, et al. The association of baseline adipocytokine levels with glycemic progression in nondiabetic Korean adults in 4 years of follow-up. Diabetes Res Clin Pract. 2012;98:501-7.
28. Graham TE, Wason CJ, Bluher M, Kahn BB. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007;50: 814-23.
29. Mejía LA, Chew F. Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron. Am J Clin Nutr. 1988;48:595-600.
30. Roodenburg AJ, West CE, Hovenier R, Beynen AC. Supplemental vitamin A enhances the recovery from iron deficiency in rats with chronic vitamin A deficiency. Br J Nutr. 1996;75:623-36.
31. Palafox NA, Gamble MV, Dancheck B, Ricks MO, Briand K, Semba RD. Vitamin A deficiency, iron deficiency, and anemia among preschool children in the Republic of the Marshall Islands. Nutrition. 2003;19: 405-8.
32. Muñoz EC, Rosado JL, Lopez P, Furr HC, Allen LH. Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. Am J Clin Nutr. 2000;71:789-94.
33. Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA. 2004;291:711-7.
34. Sun L, Zong G, Pan A, Ye X, Li H, Yu Z, Zhao Y, Zou S, Yu D, Jin Q, et al. Elevated plasma ferritin is associated with increased incidence of type 2 diabetes in middle-aged and elderly Chinese adults. J Nutr. 2013;143:1459-65.
35. Seo JA, Kim NH, Park SY, Kim HY, Ryu OH, Lee KW, Lee J, Kim DL, Choi KM, Baik SH, et al. Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease. Clin Endocrinol (Oxf). 2008;68:555-60.
36. Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Schleicher E, Fritsche A, Haring HU. High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care. 2007;30: 1173-8.
37. Nannipieri M, Gonzales C, Baldi S, Posadas R, Williams K, Haffner SM, Stern MP, Ferrannini E. Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study. Diabetes Care. 2005;28:1757-62.
38. Hellerstein MK, Schwarz JM, Neese RA. Regulation of hepatic de novo lipogenesis in humans. Annu Rev Nutr. 1996;16:523-57.
39. Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science. 2011;332:1519-23.
40. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, et al. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinaseand toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012;32:2010-9.
41. Berry DC, Noy N. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Biochim Biophys Acta 2012;1821:168-76.
42. Muenzner M, Tuvia N, Deutschmann C, Witte N, Tolkachov A, Valai A, Henze A, Sander LE, Raila J, Schupp M. Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor a activity. Mol Cell Biol. 2013;33:4068-82.
43. Vega S, Benito-Leon J, Bermejo-Pareja F, Medrano MJ, Vega-Valderrama LM, Rodriguez C, Louis ED. Several factors influenced attrition in a population-based elderly cohort: neurological disorders in Central Spain Study. J Clin Epidemiol. 2010;63:215-22.
44. Zunzunegui MV, Beland F, Gutierrez-Cuadra P. Loss to follow-up in a longitudinal study on aging in Spain. J Clin Epidemiol. 2001; 54:501-10.