Micro-CT and PET analysis of bone regeneration induced by biodegradable scaffolds as carriers for dental pulp stem cells in a rat model of calvarial "critical size" defect: Preliminary data

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 102, Issue 4, 2014, Pages 815-825

  Annibali, Susanna ^a   Bellavia, Diana ^b   Ottolenghi, Livia ^a   Cicconetti, Andrea ^a   Cristalli, Maria Paola ^a   Quaranta, Roberta ^b   Pilloni, Andrea ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

biomaterials; bone regeneration; stem cells; 18F NaF; CT; PET

Indexed keywords

BIOLOGICAL MATERIALS; BIOMATERIALS; BONE; COMPUTERIZED TOMOGRAPHY; DEFECTS; POSITRON EMISSION TOMOGRAPHY; STEM CELLS;

BETA TRICALCIUM PHOSPHATE; BONE REGENERATION; DENTAL PULP STEM CELL (DPSC); DENTAL PULP STEM CELLS; MICRO COMPUTED TOMOGRAPHY (MICRO-CT); POSITRON EMISSION TOMOGRAPHY (PET); TISSUE ENGINEERED CONSTRUCTS; [18F]-NAF;

SCAFFOLDS (BIOLOGY);

BIOMATERIAL; CALCIUM PHOSPHATE; FLUORAPATITE; FLUORINE 18; GRANULAR DEPROTEINIZED BOVINE BONE; HYDROXYAPATITE; TISSUE SCAFFOLD; TRACER; UNCLASSIFIED DRUG; BETA-TRICALCIUM PHOSPHATE; BONE PROSTHESIS; COLLAGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; BONE DENSITY; BONE MINERALIZATION; BONE PROSTHESIS; BONE REGENERATION; DENTAL PULP STEM CELL; HUMAN; HUMAN CELL; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; POSITRON EMISSION TOMOGRAPHY; RAT; SKULL DEFECT; STEM CELL; TISSUE ENGINEERING; TOOTH PULP; ANIMAL; BIODEGRADABLE IMPLANT; BOVINAE; CELL CULTURE; CELL DIFFERENTIATION; COMPUTER ASSISTED TOMOGRAPHY; CRANIOTOMY; CYTOLOGY; IMPLANT; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; NUDE RAT; OSTEOBLAST; PATHOPHYSIOLOGY; PROCEDURES; SKULL; SURGERY; SWINE; TISSUE SCAFFOLD; WOUND HEALING;

ABSORBABLE IMPLANTS; ANIMALS; BONE DENSITY; BONE REGENERATION; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CATTLE; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; CRANIOTOMY; DENTAL PULP; IMPLANTS, EXPERIMENTAL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; OSSEOINTEGRATION; OSTEOBLASTS; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, NUDE; SKULL; SWINE; TISSUE SCAFFOLDS; TOMOGRAPHY, X-RAY COMPUTED; WOUND HEALING;

EID: 84898893520     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.33064     Document Type: Article

References (50)

1. Bashutski JD, Wang HL,. Periodontal and endodontic regeneration. J Endod 2009; 35: 321-328.
2. Ward BB, Brown SE, Krebsbach PH,. Bioengineering strategies for regeneration of craniofacial bone: A review of emerging technologies. Oral Dis 2010; 16: 709-716.
3. Davies JE, Matta R, Mendes VC, Perri, de Carvalho PS,. Development, characterization and clinical use of a biodegradable composite scaffold for bone engineering in oro-maxillo-facial surgery. Organogenesis 2010; 6: 161-166.
4. Chen FM, Sun HH, Lu H, Yu Q,. Stem cell-delivery therapeutics for periodontal tissue regeneration. Biomaterials 2012; 33: 6320-6344.
5. Holtorf HL, Jansen JA, Mikos AG,. Modulation of cell differentiation in bone tissue engineering constructs cultured in a bioreactor. Adv Exp Med Biol 2006; 585: 225-241.
6. Bianco P, Robey PG,. Stem cells in tissue engineering. Nature 2001; 414: 118-121. (Pubitemid 33041636)
7. Bruder SP, Kraus KH, Goldberg VM, Kadiyala S,. The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am 1998; 80: 985-996. (Pubitemid 28355669)
8. Bruder SP, Kurth AA, Shea M, Hayes WC, Jaiswal N, Kadiyala S,. Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. J Orthop Res 1998; 16: 155-162. (Pubitemid 28249153)
9. Kon E, Muraglia A, Corsi A, Bianco P, Marcacci M, Martin I, Boyde A, Ruspantini I, Chistolini P, Rocca M, Giardino R, Cancedda R, Quarto R,. Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in criticalsize defects of sheep long bones. J Biomed Mater Res 2000; 49: 328-337. (Pubitemid 30030478)
10. Cui L, Liu B, Liu G, Zhang W, Cen L, Sun J, Yin S, Liu W, Cao Y,. Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials 2007; 28: 5477-5486. (Pubitemid 47610689)
11. Yamada Y, Ueda M, Naiki T, Takahashi M, Hata K, Nagasaka T,. Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet rich plasma: Tissue-engineered bone regeneration. Tissue Eng 2004; 10: 955-964. (Pubitemid 38880414)
12. Meinel L, Fajardo R, Hofmann S, Langer R, Chen J, Snyder B, Vunjak-Novakovic G, Kaplan D,. Silk implants for the healing of critical size bone defects. Bone 2005; 37: 688-698. (Pubitemid 41476392)
13. Mankani MH, Kuznetsov SA, Wolfe RM, Marshall GW, Robey PG,. In vivo bone formation by human bone marrow stromal cells: Reconstruction of the mouse calvarium and mandible. Stem Cells 2006; 24: 2140-2149. (Pubitemid 44477139)
14. Miura M, Miura Y, Sonoyama W, Yamaza T, Gronthos S, Shi S,. Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region. Oral Dis 2006; 12: 514-522. (Pubitemid 44624353)
15. Kassem M, Risteli L, Mosekilde L, Melsen F, Eriksen EF,. Formation of osteoblast-like cells from human mononuclear bone marrow cultures. APMIS 1991; 99: 269-274.
16. Cicconetti A, Sacchetti B, Bartoli A, Michienzi S, Corsi A, Funari A, Robey PG, Bianco P, Riminucci M,. Human maxillary tuberosity and jaw periosteum as sources of osteoprogenitor cells for tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104: 618:e1-e12.
17. Li JH, Liu DY, Zhang FM, Wang F, Zhang WK, Zhang ZT,. Human dental pulp stem cell is a promising autologous seed cell for bone tissue engineering. Chin Med J (Engl) 2011; 124: 4022-4028.
18. Yen AH, Yelick PC,. Dental tissue regeneration-A mini-review. Gerontology 2011; 57: 85-94.
19. Zhang X, Naik A, Xie C, Reynolds D, Palmer J, Lin A, Awad H, Guldberg R, Schwarz E, O'Keefe R,. Periosteal stem cells are essential for bone revitalization and repair. J Musculoskelet Neuronal Interact 2005; 5: 360-362.
20. Graziano A, d'Aquino R, Cusella-De Angelis MG, De Francesco F, Giordano A, Laino G, Piattelli A, Traini T, De Rosa A, Papaccio G,. Scaffold's surface geometry significantly affects human stem cell bone tissue engineering. J Cell Physiol 2008; 214: 166-172. (Pubitemid 350220071)
21. Graziano A, d'Aquino R, Laino G, Papaccio G,. Dental pulp stem cells: A promising tool for bone regeneration. Stem Cell Rev 2008; 4: 21-26.
22. Annibali S, Cicconetti A, Cristalli P, Giordano G, Ottolenghi L, Pilloni A,. A comparative morphometric analysis of biodegradable scaffolds as carriers for dental pulp and periosteal stem cells in a model of bone regeneration. J Craniofacial Surg 2013; 24: 866-871.
23. Jones JR, Atwood RC, Poologasundarampillai G, Yue S, Lee PD,. Quantifying the 3D macrostructure of tissue scaffolds. J Mater Sci Mater Med 2009; 20: 463-471.
24. Neiva R, Pagni G, Duarte F, Park CH, Yi E, Holman LA, Giannobile WV,. Analysis of tissue neogenesis in extraction sockets treated with guided bone regeneration: Clinical, histologic, and micro-CT results. Int J Periodontics Restorative Dent 2011; 3: 457-469.
25. Vasquez SX, Shah N, Hoberman AM,. Small animal imaging and examination by micro-CT. Methods Mol Biol 2013; 947: 223-231.
26. Ruggiu A, Tortelli F, Komlev VS, Peyrin F, Cancedda R,. Extracellular matrix deposition and scaffold biodegradation in an in vitro three-dimensional model of bone by X-ray computed microtomography. J Tissue Eng Regen Med 2012.
27. Cartmell S, Huynh K, Lin A, Nagaraja S, Guldberg R,. Quantitative microcomputed tomography analysis of mineralization within three-dimensional scaffolds in vitro. J Biomed Mater Res A 2004; 69A: 97-104. (Pubitemid 38364965)
28. Phelps ME,. PET: The merging of biology and imaging into molecular imaging J Nucl Med 2000; 41: 661-681. (Pubitemid 30207744)
29. Gronthos S, Mankani M, Brahim J, Gehron Robey P, Shi S,. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci 2000; 97: 13625-13630.
30. Karaöz E, Doǧan BN, Aksoy A, Gacar G, Akyüz S, Ayhan S, Genç ZS, Yürüker S, Duruksu, G, Demircan PÇ, Sariboyaci AE,. Isolation and in vitro characterization of dental pulp stem cells from natal teeth. Histochem Cell Biol 2010; 133: 95-112.
31. Mafi P, Hindocha S, Mafi R, Griffin M, Khan WS,. Adult mesenchymal stem cells and cell surface characterization-A systematic review of the literature Open Orthop J 2011; 5 (Suppl 2): 253-260.
32. Mangano C, De Rosa A, Desiderio V, D'Aquino R, Piattelli A, De Francesco F, Tirino V, Mangano F, Papaccio G,. The osteoblastic differentiation of dental pulp stem cells and bone formation on different titanium surface textures. Biomaterials 2010; 31: 3543-3551.
33. Umoh JU, Sampaio AV, Welch I, Pitelka V, Goldberg HA, Underhill TM, Holdsworth DW,. In vivo micro-CT analysis of bone remodeling in a rat calvarial defect model. Phys Med Biol 2009; 54: 2147-2161.
34. Schambach SJ, Bag S, Schilling L, Groden C, Brockmann MA,. Application of micro-CT in small animal imaging. Methods 2010; 50: 2-13.
35. Snoeks TJ, Kaijzel EL, Que I, Mol IM, Löwik CW, Dijkstra J,. Normalized volume of interest selection and measurement of bone volume in microCT scans. Bone 2011; 49: 1264-1269.
36. Goertzen AL, Meadors AK, Silverman RW, Cherry SR,. Simultaneous molecular and anatomical imaging of the mouse in vivo. Phys Med Biol 2002; 47: 4315-4328. (Pubitemid 36113413)
37. Berglundh T, Lindhe J,. Healing around implants placed in bone defects treated with Bio-Oss. Clin Oral Implants Res 1997; 8: 117-124.
38. Piattelli M, Favero GA, Scarano A, Orsini G, Piattelli A,. Bone reactions to anorganic bovine bone (Bio-Oss) used in sinus lifting procedure: A histologic long-term report of 20 cases in man. Int J Oral Maxillofac Implants 1999; 14: 835-840.
39. LeGeros RZ,. Properties of osteoconductive biomaterials: Calcium phosphates. Clin Orthop Relat Res 2002; 395: 81-98.
40. Sánchez-Salcedo S, Nieto A, Gõmez-Barrena E, Vallet-Regí M,. Hydroxyapatite/β-tricalcium phosphate/agarose macroporous scaffolds for bone tissue engineering. Chem Eng J 2008; 137: 62-71.
41. Nguyen LT, Liao S, Chan CK, Ramakrishna S,. Enhanced osteogenic differentiation with 3D electrospun nanofibrous scaffolds. Nanomedicine (Lond) 2012; 7: 1561-1575.
42. Valentini P, Abensur D,. Maxillary sinus floor elevation for implant placement with demineralized freeze-dried bone and bovine bone (Bio-Oss): A clinical study of 20 patients. Int J Periodontics Restorative Dent 1997; 17: 233-241. (Pubitemid 127499635)
43. Kato E, Lemler J, Sakurai K, Yamada M,. Biodegradation property of beta-tricalcium phosphate-collagen composite in accordance with bone formation: A comparative study with bio-oss collagen® in a rat critical-size defect model. Clin Implant Dent Relat Res 2012 Jul 18. [Epub ahead of print].
44. Borrelli J Jr, Prickett WD, Ricci WM,. Treatment of nonunions and osseous defects with bone graft and calcium sulfate. Clin Orthop Relat Res 2003; 411: 245-254. (Pubitemid 36667283)
45. Park CH, Rios HF, Jin Q, Sugai JV, Padial-Molina M, Taut AD, Flanagan CL, Hollister SJ, Giannobile WV,. Tissue engineering bone-ligament complexes using fiber-guiding scaffolds. Biomaterials 2012; 33: 137-145.
46. Simunek A, Kopecka D, Somanathan RV, Pilathadka S, Brazda T,. Deproteinized bovine bone versus beta-tricalcium phosphate in sinus augmentation surgery: A comparative histologic and histomorphometric study. Int J Oral Maxillofac Implants 2008; 23: 935-942.
47. Link DP, van den Dolder J, Wolke JG, Jansen JA,. The cytocompatibility and early osteogenic characteristics of an injectable calcium phosphate cement. Tissue Eng 2007; 13: 493-500. (Pubitemid 46579876)
48. Saunders R, Szymczyk KH, Shapiro IM, Adams CS,. Matrix regulation of skeletal cell apoptosis III: Mechanism of ion pair-induced apoptosis. J Cell Biochem 2007; 100: 703-715. (Pubitemid 46180533)
49. Osugi M, Katagiri W, Yoshimi R, Inukai T, Hibi H, Ueda M,. Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat calvarial bone defects. Tissue Eng A 2012; 18: 1479-1489.
50. Liu Y, Wang L, Kikuiri T, Akiyama K, Chen C, Xu X, Yang R, Chen W, Wang S, Shi S,. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α. Nat Med 2011; 17: 1594-1601.