메뉴 건너뛰기




Volumn 82, Issue 5, 2014, Pages 1823-1832

Characterization of heat-stable (STa) toxoids of enterotoxigenic Escherichia coli fused to double mutant heat-labile toxin peptide in inducing neutralizing anti-STa antibodies

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; HEAT LABILE TOXIN; NEUTRALIZING ANTIBODY; STA ANTIBODY; STA TOXOID; TOXOID; UNCLASSIFIED DRUG;

EID: 84898892168     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01394-13     Document Type: Article
Times cited : (43)

References (30)
  • 3
    • 33646204418 scopus 로고    scopus 로고
    • Future directions for research on enterotoxigenic Escherichia coli vaccines for developing countries
    • WHO
    • WHO.2006. Future directions for research on enterotoxigenic Escherichia coli vaccines for developing countries. Wkly. Epidemiol. Rec. 81:97-107.
    • (2006) Wkly. Epidemiol. Rec. , vol.81 , pp. 97-107
  • 5
    • 41749090688 scopus 로고    scopus 로고
    • Systematic review: prevention of travellers' diarrhoea
    • DuPont HL. 2008. Systematic review: prevention of travellers' diarrhoea. Aliment. Pharmacol. Ther. 27:741-751. http://dx.doi.org/10.1111/j.1365 -2036.2008.03647.x.
    • (2008) Aliment. Pharmacol. Ther. , vol.27 , pp. 741-751
    • DuPont, H.L.1
  • 7
    • 12144281678 scopus 로고    scopus 로고
    • Prevalence of enterotoxigenic Escherichia coli-associated diarrhoea and carrier state in the developing world
    • Wenneras C, Erling V. 2004. Prevalence of enterotoxigenic Escherichia coli-associated diarrhoea and carrier state in the developing world. J. Health Pop. Nut. 22:370-382.
    • (2004) J. Health Pop. Nut. , vol.22 , pp. 370-382
    • Wenneras, C.1    Erling, V.2
  • 9
    • 3042681631 scopus 로고    scopus 로고
    • Relative importance of heat-labile enterotoxin in the causation of severe diarrheal disease in the gnotobiotic piglet model by a strain of enterotoxigenic Escherichia coli that produces multiple enterotoxins
    • Berberov EM, Zhou Y, Francis DH, Scott MA, Kachman SD, Moxley RA. 2004. Relative importance of heat-labile enterotoxin in the causation of severe diarrheal disease in the gnotobiotic piglet model by a strain of enterotoxigenic Escherichia coli that produces multiple enterotoxins. Infect. Immun. 72: 3914-3424. http://dx.doi.org/10.1128/IAI.72.7.3914-3924.2004.
    • (2004) Infect. Immun. , vol.72 , pp. 3424-3914
    • Berberov, E.M.1    Zhou, Y.2    Francis, D.H.3    Scott, M.A.4    Kachman, S.D.5    Moxley, R.A.6
  • 10
    • 33646908791 scopus 로고    scopus 로고
    • Significance of heat-stable and heat-labile enterotoxins in porcine colibacillosis in an additive model for pathogenicity studies
    • Zhang W, Berberov EM, Freeling J, He D, Moxley RA, Francis DH. 2006. Significance of heat-stable and heat-labile enterotoxins in porcine colibacillosis in an additive model for pathogenicity studies. Infect. Immun. 74:3107-3114. http://dx.doi.org/10.1128/IAI.01338-05.
    • (2006) Infect. Immun. , vol.74 , pp. 3107-3114
    • Zhang, W.1    Berberov, E.M.2    Freeling, J.3    He, D.4    Moxley, R.A.5    Francis, D.H.6
  • 11
    • 72449165391 scopus 로고    scopus 로고
    • Toxin-mediated effects on the innate mucosal defenses: implications for enteric vaccines
    • Glenn GM, Francis DH, Danielsen EM. 2009. Toxin-mediated effects on the innate mucosal defenses: implications for enteric vaccines. Infect. Immun. 77:5206-5215. http://dx.doi.org/10.1128/IAI.00712-09.
    • (2009) Infect. Immun. , vol.77 , pp. 5206-5215
    • Glenn, G.M.1    Francis, D.H.2    Danielsen, E.M.3
  • 12
    • 13244272289 scopus 로고    scopus 로고
    • Vaccines for enterotoxigenic Escherichia coli: current status
    • Boedeker EC. 2005. Vaccines for enterotoxigenic Escherichia coli: current status. Curr. Opin. Gastroenterol. 21:15-19.
    • (2005) Curr. Opin. Gastroenterol. , vol.21 , pp. 15-19
    • Boedeker, E.C.1
  • 13
    • 79952929452 scopus 로고    scopus 로고
    • From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development
    • Svennerholm AM. 2011. From cholera to enterotoxigenic Escherichia coli (ETEC) vaccine development. Ind. J. Med. Res. 133:188-196.
    • (2011) Ind. J. Med. Res. , vol.133 , pp. 188-196
    • Svennerholm, A.M.1
  • 14
    • 84864949289 scopus 로고    scopus 로고
    • Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans
    • Zhang W, Sack DA. 2012. Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans. Expert Rev. Vaccines 11:677-684. http://dx.doi.org/10.1586/erv.12.37.
    • (2012) Expert Rev. Vaccines , vol.11 , pp. 677-684
    • Zhang, W.1    Sack, D.A.2
  • 15
    • 0011053586 scopus 로고
    • Development of an oral vaccine against enterotoxigenic Escherichia coli diarrhea
    • Wadstrom T, Makela PH, Svennerholm AM, Wolf-Watz H (ed), Plenum Press, London, United Kingdom.
    • Svennerholm AM, Ahren C, Wenneras C, Holmgren J. 1991. Development of an oral vaccine against enterotoxigenic Escherichia coli diarrhea, p 287-294. In. Wadstrom T, Makela PH, Svennerholm AM, Wolf-Watz H (ed), Molecular pathogenesis of gastrointestinal infections, Plenum Press, London, United Kingdom.
    • (1991) Molecular pathogenesis of gastrointestinal infections , pp. 287-294
    • Svennerholm, A.M.1    Ahren, C.2    Wenneras, C.3    Holmgren, J.4
  • 16
    • 83455259570 scopus 로고    scopus 로고
    • Generation and characterization of a live attenuated enterotoxigenic Escherichia coli combination vaccine expressing six colonization factors and heat-labile toxin subunit B
    • Turner AK, Stephens JC, Beavis JC, Greenwood J, Gewert C, Randall R, Freeman D, Darsley MJ. 2011. Generation and characterization of a live attenuated enterotoxigenic Escherichia coli combination vaccine expressing six colonization factors and heat-labile toxin subunit B. Clin. Vaccine Immunol. 18:2128-2135. http://dx.doi.org/10.1128/CVI.05345-11.
    • (2011) Clin. Vaccine Immunol. , vol.18 , pp. 2128-2135
    • Turner, A.K.1    Stephens, J.C.2    Beavis, J.C.3    Greenwood, J.4    Gewert, C.5    Randall, R.6    Freeman, D.7    Darsley, M.J.8
  • 17
    • 0025305320 scopus 로고
    • Construction of a nontoxic fusion peptide for immunization against Escherichia coli strains that produce heat-labile and heatstable enterotoxin
    • Clements JD. 1990. Construction of a nontoxic fusion peptide for immunization against Escherichia coli strains that produce heat-labile and heatstable enterotoxins. Infect. Immun. 1990. 58:1159-1166.
    • (1990) Infect. Immun. 1990. , vol.58 , pp. 1159-1166
    • Clements, J.D.1
  • 18
    • 0031986077 scopus 로고    scopus 로고
    • Safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli vaccine
    • Jertborn M, Ahren C, Holmgren J, Svennerholm AM. 1998. Safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli vaccine. Vaccine 16:255-260. http://dx.doi.org/10.1016/S0264-410X(97)00169-2.
    • (1998) Vaccine , vol.16 , pp. 255-260
    • Jertborn, M.1    Ahren, C.2    Holmgren, J.3    Svennerholm, A.M.4
  • 19
    • 77951221998 scopus 로고    scopus 로고
    • Heat-stable enterotoxin of enterotoxigenic Escherichia coli as a vaccine target
    • Taxt A, Aasland R, Sommerfelt H, Nataro J, Puntervoll P. 2010. Heat-stable enterotoxin of enterotoxigenic Escherichia coli as a vaccine target. Infect. Immun. 78:1824-1831. http://dx.doi.org/10.1128/IAI.01397-09.
    • (2010) Infect. Immun. , vol.78 , pp. 1824-1831
    • Taxt, A.1    Aasland, R.2    Sommerfelt, H.3    Nataro, J.4    Puntervoll, P.5
  • 20
    • 0001021175 scopus 로고
    • Oral B-subunit whole-cell vaccines against cholera and enterotoxigenic Escherichia coli diarrhoea
    • Dlawer A, Ala'Aldeen A, Hormaeche CE (ed). John Wiley & Sons, Ltd, Chichester, United Kingdom.
    • Svennerholm AM, Holmgren J. 1995. Oral B-subunit whole-cell vaccines against cholera and enterotoxigenic Escherichia coli diarrhoea, p 205-232. In Dlawer A, Ala'Aldeen A, Hormaeche CE (ed), Molecular and clinical aspects of bacterial vaccine development. John Wiley & Sons, Ltd, Chichester, United Kingdom.
    • (1995) Molecular and clinical aspects of bacterial vaccine development , pp. 205-232
    • Svennerholm, A.M.1    Holmgren, J.2
  • 21
    • 73449147008 scopus 로고    scopus 로고
    • Genetic fusions of heat-labile (LT) and heat-stable (ST) toxoids of porcine enterotoxigenic Escherichia coli elicit neutralizing anti-LT and anti-STa antibodies
    • Zhang W, Zhang C, Francis DH, Fang Y, Knudsen D, Nataro JP, Robertson DC. 2010. Genetic fusions of heat-labile (LT) and heat-stable (ST) toxoids of porcine enterotoxigenic Escherichia coli elicit neutralizing anti-LT and anti-STa antibodies. Infect. Immun. 78:316-325. http://dx.doi.org/10.1128/IAI.00497-09.
    • (2010) Infect. Immun. , vol.78 , pp. 316-325
    • Zhang, W.1    Zhang, C.2    Francis, D.H.3    Fang, Y.4    Knudsen, D.5    Nataro, J.P.6    Robertson, D.C.7
  • 22
    • 80053436233 scopus 로고    scopus 로고
    • Heat-labile-and heat-stable-toxoid fusions (LTR192G-STaP13F) of human enterotoxigenic Escherichia coli elicit neutralizing antitoxin antibodies
    • Liu M, Ruan X, Zhang C, Lawson SR, Knudsen DE, Nataro JP, Robertson DC, Zhang W. 2011. Heat-labile-and heat-stable-toxoid fusions (LTR192G-STaP13F) of human enterotoxigenic Escherichia coli elicit neutralizing antitoxin antibodies. Infect. Immun. 79:4002-4009. http://dx.doi.org/10.1128/IAI.00165-11.
    • (2011) Infect. Immun. , vol.79 , pp. 4002-4009
    • Liu, M.1    Ruan, X.2    Zhang, C.3    Lawson, S.R.4    Knudsen, D.E.5    Nataro, J.P.6    Robertson, D.C.7    Zhang, W.8
  • 23
    • 80053181078 scopus 로고    scopus 로고
    • Modified heat-stable toxins (hSTa) of enterotoxigenic Escherichia coli lose toxicity but display antigenicity after being genetically fused to heat-labile toxoid LT(R192G)
    • Liu M, Zhang C, Mateo K, Nataro JP, Robertson DC, Zhang W. 2011. Modified heat-stable toxins (hSTa) of enterotoxigenic Escherichia coli lose toxicity but display antigenicity after being genetically fused to heat-labile toxoid LT(R192G). Toxins (Basel) 3:1146-1162. http://dx.doi.org/10.3390/toxins3091146.
    • (2011) Toxins (Basel) , vol.3 , pp. 1146-1162
    • Liu, M.1    Zhang, C.2    Mateo, K.3    Nataro, J.P.4    Robertson, D.C.5    Zhang, W.6
  • 24
    • 84885402756 scopus 로고    scopus 로고
    • Toxicity and immunogenicity of enterotoxigenic Escherichia coli heat-labile and heat-stable toxoid fusion 3xSTaA14Q-LTS63K/R192G/L211A in a murine model
    • The STa Toxoid Vaccine Consortium Group.
    • Zhang C, Knudsen DE, Liu M, Robertson DC, Zhang W, and the STa Toxoid Vaccine Consortium Group. 2013. Toxicity and immunogenicity of enterotoxigenic Escherichia coli heat-labile and heat-stable toxoid fusion 3xSTaA14Q-LTS63K/R192G/L211A in a murine model. PLoS One 8:e77386. http://dx.doi.org/10.1371/journal.pone.0077386.
    • (2013) PLoS One , vol.8
    • Zhang, C.1    Knudsen, D.E.2    Liu, M.3    Robertson, D.C.4    Zhang, W.5
  • 25
    • 79954535010 scopus 로고    scopus 로고
    • Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant
    • Norton EB, Lawson LB, Freytag LC, Clements JD. 2011. Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant. Clin. Vaccine Immunol. 18:546-551. http://dx.doi.org/10.1128/CVI.00538-10.
    • (2011) Clin. Vaccine Immunol. , vol.18 , pp. 546-551
    • Norton, E.B.1    Lawson, L.B.2    Freytag, L.C.3    Clements, J.D.4
  • 27
    • 80053453426 scopus 로고    scopus 로고
    • A tripartite fusion, FaeGFedF-LT(192)A2:B, of enterotoxigenic Escherichia coli (ETEC) elicits antibodies that neutralize cholera toxin, inhibit adherence of K88 (F4) and F18 fimbriae, and protect pigs against K88ac/heat-labile toxin infection
    • Ruan X, Liu M, Casey TA, Zhang W. 2011. A tripartite fusion, FaeGFedF-LT(192)A2:B, of enterotoxigenic Escherichia coli (ETEC) elicits antibodies that neutralize cholera toxin, inhibit adherence of K88 (F4) and F18 fimbriae, and protect pigs against K88ac/heat-labile toxin infection. Clin. Vaccine Immunol. 18:1593-1599. http://dx.doi.org/10.1128/CVI.05120-11.
    • (2011) Clin. Vaccine Immunol. , vol.18 , pp. 1593-1599
    • Ruan, X.1    Liu, M.2    Casey, T.A.3    Zhang, W.4
  • 28
    • 0003633755 scopus 로고    scopus 로고
    • National Research Council. National Academy Press, Washington, DC.
    • National Research Council. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, DC.
    • (1996) Guide for the care and use of laboratory animals
  • 29
    • 52649125764 scopus 로고    scopus 로고
    • Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model
    • Zhang W, Robertson DC, Zhang C, Bai W, Zhao M, Francis DH. 2008. Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model. Appl. Environ. Microbiol. 74:5832-5837. http://dx.doi.org/10.1128/AEM.00893-08.
    • (2008) Appl. Environ. Microbiol. , vol.74 , pp. 5832-5837
    • Zhang, W.1    Robertson, D.C.2    Zhang, C.3    Bai, W.4    Zhao, M.5    Francis, D.H.6
  • 30
    • 1942438147 scopus 로고    scopus 로고
    • Structural features of Escherichia coli heatstable enterotoxin that activates membrane-associated guanylyl cyclase
    • Sato T, Shimonishi Y. 2004. Structural features of Escherichia coli heatstable enterotoxin that activates membrane-associated guanylyl cyclase. J. Peptide Res. 63:200-206. http://dx.doi.org/10.1111/j.1399-3011.2004.00125.x.
    • (2004) J. Peptide Res. , vol.63 , pp. 200-206
    • Sato, T.1    Shimonishi, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.