Pentoxifylline reduces chronic post-ischaemia pain by alleviating microvascular dysfunction

European Journal of Pain (United Kingdom)

Volumn 18, Issue 3, 2014, Pages 406-414

  Vaigunda Ragavendran, J ^a,b   Laferriere A ^a   Khorashadi, M ^a   Coderre, T J ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PENTOXIFYLLINE; VASODILATOR AGENT;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; CHRONIC POST ISCHAEMIA PAIN; CONTROLLED STUDY; DRUG EFFECT; HYPEREMIA; ISCHEMIA; LASER DOPPLER FLOWMETRY; MALE; MICROANGIOPATHY; MICROVASCULAR DYSFUNCTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SYSTEMIC THERAPY; TIME TO TREATMENT; TISSUE PERFUSION; VON FREY TEST; ANIMAL; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; LONG EVANS RAT; MICROVASCULATURE; PAIN MEASUREMENT; PATHOPHYSIOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; ISCHEMIA; MALE; MICROVESSELS; PAIN; PAIN MEASUREMENT; PENTOXIFYLLINE; RATS; RATS, LONG-EVANS; REPERFUSION INJURY; VASODILATOR AGENTS;

EID: 84898891362     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1002/j.1532-2149.2013.00381.x     Document Type: Article

References (37)

1. Accetto, B., (1982). Beneficial hemorheologic therapy of chronic peripheral arterial disorders with pentoxifylline: Results of double-blind study versus vasodilator-nylidrin. Am Heart J 103, 864-869.
2. Adams, J.G. Jr, Dhar, A., Shukla, S.D., Silver, D., (1995). Effect of pentoxifylline on tissue injury and platelet-activating factor production during ischemia-reperfusion injury. J Vasc Surg 21, 742-748.
3. Al-Saad, R.Z., Hussain, S.A., Numan, I.T., (2012). Dose-response relationship of the anti-inflammatory activity of pentoxifylline in experimental models of chronic inflammation. Pharmacologia 3, 39-45.
4. Baron, R., Janig, W., (2004). Complex regional pain syndromes-how do we escape the diagnostic trap ? Lancet 364, 1739-1741.
5. Birklein, F., Weber, M., Neundorfer, B., (2000). Increased skin lactate in complex regional pain syndrome: Evidence for tissue hypoxia ? Neurology 55, 1213-1215.
6. Bollinger, A., Hoffmann, U., Franzeck, U.K., (1996). Microvascular changes in arterial occlusive disease: Target for pharmacotherapy. Vasc Med 1, 50-54.
7. Bowton, D.L., Stump, D.A., Prough, D.S., Toole, J.F., Lefkowitz, D.S., Coker, L., (1989). Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease. Stroke 20, 1662-1666.
8. Bradbury, A.W., Murie, J.A., Ruckley, C.V., (1993). Role of the leucocyte in the pathogenesis of vascular disease. Br J Surg 80, 1503-1512.
9. Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M., Yaksh, T.L., (1994). Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53, 55-63.
10. Coderre, T.J., Xanthos, D.N., Francis, L., Bennett, G.J., (2004). Chronic post-ischemia pain (CPIP): A novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hind paw ischemia and reperfusion in the rat. Pain 112, 94-105.
11. Corcoran, H.A., Smith, B.E., Mathers, P., Pisacreta, D., Hershey, J.C., (2009). Laser Doppler imaging of reactive hyperemia exposes blood flow deficits in a rat model of experimental limb ischemia. J Cardiovasc Pharmacol 53, 446-451.
12. Dakak, N., Husain, S., Mulcahy, D., Andrews, N.P., Panza, J.A., Waclawiw, M., Schenke, W., Quyyumi, A.A., (1998). Contribution of nitric oxide to reactive hyperemia: Impact of endothelial dysfunction. Hypertension 32, 9-15.
13. Dinn, R.F., Yang, H.T., Terjung, R.L., (1990). The influence of pentoxifylline and torbafylline on muscle blood flow in animals with peripheral arterial insufficiency. J Clin Pharmacol 30, 704-710.
14. Eckly-Michel, A., Martin, V., Lugnier, C., (1997). Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation. Br J Pharmacol 122, 158-164.
15. Ernst, E., (1994). Pentoxifylline for intermittent claudication. A critical review. Angiology 45, 339-345.
16. Horton, J.W., White, D.J., (1993). Free radical scavengers prevent intestinal ischemia-reperfusion-mediated intestinal dysfunction. J Surg Res 55, 282-289.
17. Jacoby, D., Mohler, E.R. 3rd,. (2004). Drug treatment of intermittent claudication. Drugs 64, 1657-1670.
18. Kamphuis, J., Smits, P., Thien, T., (1994). Vascular effects of pentoxifylline in humans. J Cardiovasc Pharmacol 24, 648-654.
19. Kishi, M., Tanaka, H., Seiyama, A., Takaoka, M., Matsuoka, T., Yoshioka, T., Sugimoto, H., (1998). Pentoxifylline attenuates reperfusion injury in skeletal muscle after partial ischemia. Am J Physiol 274, H1435-H1442.
20. Koban, M., Leis, S., Schultze-Mosgau, S., Birklein, F., (2003). Tissue hypoxia in complex regional pain syndrome. Pain 104, 149-157.
21. Kurvers, H.A., Jacobs, M.J., Beuk, R.J., Van Den Wildenberg, F.A., Kitslaar, P.J., Slaaf, D.W., Reneman, R.S., (1995). Reflex sympathetic dystrophy: Evolution of microcirculatory disturbances in time. Pain 60, 333-340.
22. Laferrière, A., Millecamps, M., Xanthos, D.N., Xiao, W.H., Siau, C., de Mos, M., Sachot, C., Ragavendran, J.V., Huygen, F.J., Bennett, G.J., Coderre, T.J., (2008). Cutaneous tactile allodynia associated with microvascular dysfunction in muscle. Mol Pain 4, 49-59.
23. Liu, J., Feng, X., Yu, M., Xie, W., Zhao, X., Li, W., Guan, R., Xu, J., (2007). Pentoxifylline attenuates the development of hyperalgesia in a rat model of neuropathic pain. Neurosci Lett 412, 268-272.
24. Mika, J., Osikowicz, M., Rojewska, E., Korostynski, M., Wawrzczak-Bargiela, A., Przewlocki, R., Przewlocka, B., (2009). Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain. Eur J Pharmacol 623, 65-72.
25. Perez, R.S., Zuurmond, W.W., Bezemer, P.D., Kuik, D.J., van Loenen, A.C., de Lange, J.J., Zuidhof, A.J., (2003). The treatment of complex regional pain syndrome type I with free radical scavengers: A randomized controlled study. Pain 102, 297-307.
26. Rochetaing, A., Kreher, P., (2003). Reactive hyperemia during early reperfusion as a determinant of improved functional recovery in ischemic preconditioned rat hearts. J Thorac Cardiovasc Surg 125, 1516-1525.
27. Samlaska, C.P., Winfield, E.A., (1994). Pentoxifylline. J Am Acad Dermatol 30, 603-621.
28. Schwartzman, R.J., Alexander, G.M., Grothusen, J., (2006). Pathophysiology of complex regional pain syndrome. Expert Rev Neurother 6, 669-681.
29. Stanton-Hicks, M., (2003). Complex regional pain syndrome. Anesthesiol Clin North Am 21, 733-744.
30. Strieter, R.M., Remick, D.G., Ward, P.A., Spengler, R.N., Lynch, J.P. 3rd, Larrick, J., Kunkel, S.L., (1988). Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun 155, 1230-1236.
31. Vale, M.L., Benevides, V.M., Sachs, D., Brito, G.A., Da Rocha, F.A., Poole, S., Ferreira, S.H., Cunha, F.Q., Ribeiro, R.A., (2004). Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br J Pharmacol 143, 833-844.
32. Wall, P.D., Woolf, C.J., (1984). Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. J Physiol 356, 443-458.
33. Ward, A., Clissold, S.P., (1987). Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 34, 50-97.
34. Wei, T., Sabsovich, I., Guo, T.Z., Shi, X., Zhao, R., Li, W., Geis, C., Sommer, C., Kingery, W.S., Clark, D.J., (2009). Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome. Eur J Pain 13, 253-262.
35. Wordliczek, J., Szczepanik, A.M., Banach, M., Turchan, J., Zembala, M., Siedlar, M., Przewlocki, R., Serednicki, W., Przewlocka, B., (2000). The effect of pentoxifylline on post-injury hyperalgesia in rats and postoperative pain in patients. Life Sci 66, 1155-1164.
36. Wu, P.H., Barraco, R.A., Phillis, J.W., (1984). Further studies on the inhibition of adenosine uptake into rat brain synaptosomes by adenosine derivatives and methylxanthines. Gen Pharmacol 15, 251-254.
37. Zollinger, P.E., Tuinebreijer, W.E., Kreis, R.W., Breederveld, R.S., (1999). Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: A randomized trial. Lancet 354, 2025-2028.