Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)- 1H,3H-pyrrolo[1,2-c]thiazoles

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 273-281

  Santos, Kathleen ^a   Laranjo, Mafalda ^a,b   Abrantes, Ana Margarida ^a,b   Brito, Ana F ^a,b   Gonçalves, Cristina ^a   Sarmento Ribeiro, Ana Bela ^a   Botelho, M Filomena ^a,b   Soares, Maria I L ^c   Oliveira, Andreia S R ^c   Pinho E Melo, Teresa M V D ^c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

6,7 Bis(hydroxymethyl) 1H,3H pyrrolo 1,2 c thiazole; Antitumor activity; Breast cancer; Triple negative breast cancer

Indexed keywords

2 (4 HYDROXYPHENYL) 1,3 THIAZOLIDINE 4 CARBOXYLIC ACID; 2 (4 METHOXYPHENYL) 1,3 THIAZOLIDINE 4 CARBOXYLIC ACID; 5,5 DIMETHYL 2 PHENYL 1,3 THIAZOLIDINE 4 CARBOXYLIC ACID; 6,7 BIS(HYDROXYMETHYL) 1,1,5 TRIMETHYL 3 PHENYL 1H,3H PYRROLO[1,2 C]THIAZOLE; 6,7 BIS(HYDROXYMETHYL) 1H,3H PYRROLO[1,2 C ]THIAZOLE DERIVATIVE; 6,7 BIS(HYDROXYMETHYL) 3 (4 HYDROXYPHENYL) 5 METHYL 1H,3H PYRROLO[1,2 C]THIAZOLE; 6,7 BIS(HYDROXYMETHYL) 3 (4 METHOXYPHENYL) 5 METHYL 1H,3H PYRROLO[1,2 C]THIAZOLE; ANTINEOPLASTIC AGENT; DIMETHYL 1,1,5 TRIMETHYL 3 PHENYL 1H,3H PYRROLO[1,2 C] THIAZOLE 6,7 DICARBOXYLATE; DIMETHYL 3 (4 ACETHOXYPHENYL) 5 METHYL 1H,3H PYRROLO[1,2 C]THIAZOLE 6,7 DICARBOXYLATE; DIMETHYL 3 (4 METHOXYPHENYL) 5 METHYL 1H,3H PYRROLO[1,2 C]THIAZOLE 6,7 DICARBOXYLATE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; 6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO(1,2-C)THIAZOLE; PYRROLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CHIRALITY; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLOADDITION; DIASTEREOISOMER; DNA DAMAGE; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; LONG TERM SURVIVAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SURVIVAL FACTOR; TARGET CELL; TRIPLE NEGATIVE BREAST CANCER; BREAST NEOPLASMS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FEMALE; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; SYNTHESIS; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 84898876196     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.008     Document Type: Article

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