Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells

Angiogenesis

Volumn 17, Issue 2, 2014, Pages 419-427

  Kesler, Cristina T ^a   Kuo, Angera H ^a,b   Wong, Hon Kit ^a   Masuck, David J ^a   Shah, Jennifer L ^a,b   Kozak, Kevin R ^a,c   Held, Kathryn D ^a   Padera, Timothy P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Lymphangiogenesis; Lymphatic endothelium; Lymphedema; Radiotherapy; VEGF C

Indexed keywords

HISTONE H2AX; VASCULOTROPIN C; PROTECTIVE AGENT;

APOPTOSIS; ARTICLE; CELL CYCLE ASSAY; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL LEVEL; CELL SURVIVAL; CELLULAR DISTRIBUTION; CLONOGENIC ASSAY; COLONY FORMATION; CONTROLLED STUDY; DNA DAMAGE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; LYMPHANGIOGENESIS; LYMPHATIC ENDOTHELIAL CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RADIATION DOSE; RADIATION INJURY; RADIOSENSITIVITY; X RAY; ADULT; CELL CYCLE; DRUG EFFECTS; METABOLISM;

ADULT; APOPTOSIS; CELL CYCLE; CELL SURVIVAL; DNA DAMAGE; ENDOTHELIAL CELLS; HUMANS; LYMPHANGIOGENESIS; PROTECTIVE AGENTS; RADIATION TOLERANCE; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84898857209     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-013-9400-7     Document Type: Article

References (26)

1. Warren AG et al (2007) Lymphedema: a comprehensive review. Ann Plast Surg 59(4):464-472
2. Meek AG (1998) Breast radiotherapy and lymphedema. Cancer 83(12 Suppl American):2788-2797
3. Hinrichs CS et al (2004) Lymphedema secondary to postmastectomy radiation: incidence and risk factors. Ann Surg Oncol 11(6):573-580
4. Tammela T et al (2007) Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nat Med 13(12):1458-1466
5. Gershenwald JE, Fidler IJ (2002) Targeting lymphatic metastasis. Science 296(5574):1811-1812
6. Gorski DH et al (1999) Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 59(14):3374-3378
7. Gupta VK et al (2002) Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J 8(1):47-54
8. Karkkainen MJ et al (2004) Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 5(1):74-80
9. Avraham T et al (2010) Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis. Am J Physiol Cell Physiol 299(3):C589-C605
10. Jackowski S et al (2007) Radiogenic lymphangiogenesis in the skin. Am J Pathol 171(1):338-348
11. McMahon AM et al (1994) The effects of radiation on the contractile activity of guinea pig mesenteric lymphatics. Lymphology 27(4):193-200
12. Mortimer PS et al (1991) Time-related changes in lymphatic clearance in pig skin after a single dose of 18 Gy of X rays. Br J Radiol 64(768):1140-1146
13. Sung HK et al (2006) Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis. Biochem Biophys Res Commun 345(2):545-551
14. Ch'ang HJ et al (2005) ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med 11(5):484-490
15. Nagy JA et al (2002) VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations. Cold Spring Harb Symp Quant Biol 67:227-237
16. Joukov V et al (1996) A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 15(7):1751
17. Kukk E et al (1996) VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development 122(12):3829-3837
18. Kubo H et al (2002) Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proc Natl Acad Sci USA 99(13):8868-8873
19. Franken NA et al (2006) Clonogenic assay of cells in vitro. Nat Protoc 1(5):2315-2319
20. Makinen T et al (2001) Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J 20(17):4762-4773
21. Rhee JG, Lee I, Song CW (1986) The clonogenic response of bovine aortic endothelial cells in culture to radiation. Radiat Res 106(2):182-189
22. Cho MM et al (1999) Estrogen modulates paracellular permeability of human endothelial cells by eNOS- and iNOS-related mechanisms. Am J Physiol 276(2 Pt 1):C337-C349
23. Abdollahi A et al (2003) SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res 63(13):3755-3763
24. Paull TT et al (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10(15):886-895
25. Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182(3):311-322
26. Donker M et al (2007) Negligible radiation protection of endothelial cells by vascular endothelial growth factor. Oncol Rep 18(3):709-714