A rapid and sensitive UPLC-MS/MS method for quantification of two caffeoylquinic acids and four main active components in rat plasma after an intravenous administration of Qingkailing injection and its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 28, Issue 5, 2014, Pages 601-609

  Peng, Long ^a   Gao, Xiaoyan ^a   Song, Yuelin ^a   Zhao, Longshan ^b   Guo, Mingxing ^a   Su, Jiankun ^a   Zhang, Li ^a   Liu, Haiyu ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Caffeoylquinic acids; Intravenous; Pharmacokinetics; Qingkailing injection; UPLC MS MS

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; FLAVONOIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINE; RATS;

ACTIVE COMPONENTS; ADVERSE DRUG REACTIONS; ANALYTES; CAFFEOYLQUINIC ACIDS; INTRAVENOUS; INTRAVENOUS ADMINISTRATION; PHARMACOKINETIC STUDIES; QINGKAILING INJECTIONS; RAT PLASMA; UPLC-MS/MS;

PHARMACOKINETICS;

BAICALIN; CHINESE DRUG; CHLOROGENIC ACID; CHOLIC ACID; GENIPOSIDE; HYODEOXYCHOLIC ACID; ISORHAMNETIN; NEOCHLOROGENIC ACID; QINGKAILING; QUINIC ACID; UNCLASSIFIED DRUG; CAFFEOYLQUINIC ACID; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MEGADOSE; ELUTION; EXPERIMENTAL RAT; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NEGATIVE ION ELECTROSPRAY; NONHUMAN; PH; PLASMA CONCENTRATION-TIME CURVE; QUALITY CONTROL; RAT; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; EVALUATION STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; PROCEDURES; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT;

RATTUS;

ADMINISTRATION, INTRAVENOUS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; MALE; QUINIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84898851164     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3077     Document Type: Article

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