Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer

Gynecological Endocrinology

Volumn 30, Issue 5, 2014, Pages 359-362

  Nishihara, Takuji ^a   Hashimoto, Shu ^a   Ito, Keijiro ^a   Nakaoka, Yoshiharu ^a   Matsumoto, Kazuya ^b   Hosoi, Yoshihiko ^b   Morimoto, Yoshiharu ^a  

^a IVF Namba Clinic   (Japan)

^b KINKI UNIVERSITY   (Japan)

Author keywords

Assisted reproductive technology; Melatonin; Oxidative stress; Reactive oxygen species

Indexed keywords

BUSERELIN; MELATONIN; RECOMBINANT FOLLITROPIN;

ARTICLE; ARTIFICIAL INSEMINATION; BLASTOCYST; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; FOLLOW UP; HUMAN; INNER CELL MASS; INTRACYTOPLASMIC SPERM INJECTION; OOCYTE DEVELOPMENT; OOCYTE RETRIEVAL; OXIDATIVE STRESS; PRIORITY JOURNAL; SUPPLEMENTATION; TREATMENT DURATION; TREATMENT OUTCOME; ADULT; CLINICAL TRIAL; DRUG EFFECTS; INFERTILITY, FEMALE; MALE; OOCYTE; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PREGNANCY; PROCEDURES;

ADMINISTRATION, ORAL; ADULT; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; MALE; MELATONIN; OOCYTES; PREGNANCY;

EID: 84898846282     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2013.879856     Document Type: Article

References (23)

1. Fujii J, Iuchi Y, Okada F. Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system. Reprod Biol Endocrinol 2005;3:43-52
2. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005;3:28
3. Guerin P, El Mouatassim S, Menezo Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum Reprod Update 2001;7:175-89
4. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril 2003;79:829-43
5. Rizzo A, Roscino M, Binetti F, Sciorsci R. Roles of reactive oxygen species in female reproduction. Reprod Domest Anim 2012;47:344-52
6. Zavodnik IB, Domanski AV, Lapshina EA, et al. Melatonin directly scavenges free radicals generated in red blood cells and a cell-free system: chemiluminescence measurements and theoretical calculations. Life Sci 2006;79:391-400
7. Tomas-Zapico C, Coto-Montes A. A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes. J Pineal Res 2005;39:99-104
8. Tamura H, Takasaki A, Miwa I, et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res 2008;44: 280-7
9. Tamura H, Takasaki A, Taketani T, et al. The role of melatonin as an antioxidant in the follicle. J Ovarian Res 2012;5:5
10. Bat?oǧlu AS, Sahin U, Gürlek B, et al. The efficacy of melatonin administration on oocyte quality. Gynecol Endocrinol 2012;28:91-3
11. Nakamura Y, Tamura H, Takayama H, Kato H. Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertil Steril 2003;80: 1012-16
12. LaRosa C, Downs SM. Stress stimulates AMP-activated protein kinase and meiotic resumption in mouse oocytes. Biol Reprod 2006; 74:585-92
13. Kang JT, Koo OJ, Kwon DK, et al. Effects of melatonin on preimplantation development of porcine parthenogenetic embryos. Reprod Fertil Dev 2009;22:327-8
14. Manjunatha BM, Devaraj M, Gupta PSP, et al. Effect of taurine and melatonin in the culture medium on buffalo in vitro embryo development. Reprod Domest Anim 2009;44:12-16
15. Ahn HJ, Bae IH. Effects of melatonin on the meiotic maturation of mouse oocytes in vitro. Korean J Fertil Steril 2004;31: 155-68
16. Na K, Kim J, Lee J, et al. Effect of melatonin on the maturation of mouse GV oocytes and apoptosis of cumulus cells in vitro. Fertil Steril 2005;84:S103Abst.
17. Tamura H, Takasaki A, Miwa I, et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. J Pineal Res 2007;44: 280-7
18. Tian XZ, Wen Q, Shi JM, et al. Effects of melatonin on in vitro development of mouse two-cell embryos cultured in HTF medium. Endocr Res 2010;35:17-23
19. Rodriguez-Osorio N, Kim IJ, Wang H, et al. Melatonin increases cleavage rate of porcine preimplantation embryos in vitro. J Pineal Res 2007;43:283-8
20. Papis K, Poleszczuk O, Wenta-Muchalska E, Modlinski JA. Melatonin effect on bovine embryo development in vitro in relation to oxygen concentration. J Pineal Res 2007;43:321-6
21. Unfer V, Raffone E, Rizzo P, Buffo S. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. Gynecol Endocrinol 2011;27:857-61
22. Eryilmaz OG, Devran A, Sarikaya E, et al. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J Assist Reprod Genet 2011;28:815-20
23. Carr R, Wasdell MB, Hamilton D, et al. Long-term effectiveness outcome of melatonin therapy in children with treatmentresistant circadian rhythm sleep disorders. J Pineal Res 2007;43: 351-9.