The impact of frailty on pharmacokinetics in older people: Using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtration

European Journal of Clinical Pharmacology

Volumn 70, Issue 5, 2014, Pages 549-555

  Johnston, Claire ^a,b   Hilmer, Sarah N ^a,b   McLachlan, Andrew J ^c,d   Matthews, Slade T ^a   Carroll, Peter R ^a,b   Kirkpatrick, Carl M ^e  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c ANZAC Research Institute   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e MONASH UNIVERSITY   (Australia)

Author keywords

Ageing; Frailty; Gentamicin; Glomerular filtration; Pharmacokinetics; Population pharmacokinetics; Renal clearance

Indexed keywords

CREATININE; GENTAMICIN;

AGED; AGING; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; CREATININE CLEARANCE; DRUG CLEARANCE; FEMALE; GLOMERULUS FILTRATION; HUMAN; KIDNEY FUNCTION; LEAN BODY WEIGHT; MALE; PHARMACOKINETICS; PRIORITY JOURNAL; BIOLOGICAL MODEL; BLOOD; FRAIL ELDERLY; GLOMERULUS FILTRATION RATE; KIDNEY; METABOLIC CLEARANCE RATE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; FEMALE; FRAIL ELDERLY; GENTAMICINS; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; MALE; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL;

EID: 84898843931     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-014-1652-7     Document Type: Article

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