Neurological aspects of human parvovirus B19 infection: A systematic review

Reviews in Medical Virology

Volumn 24, Issue 3, 2014, Pages 154-168

  Barah, Faraj ^a   Whiteside, Sigrid ^b,d   Batista, Sonia ^c   Morris, Julie ^b,d  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d WYTHENSHAWE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN M; STEROID; VIRUS ANTIBODY; VIRUS DNA;

ANEMIA; ANTIBODY DETECTION; BLOOD ANALYSIS; CEREBROSPINAL FLUID ANALYSIS; CHRONIC FATIGUE SYNDROME; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DNA DETERMINATION; ENCEPHALITIS; ERYTHEMA INFECTIOSUM; HUMAN; IMMUNOCOMPROMISED PATIENT; LANGUAGE DISABILITY; MENINGOENCEPHALITIS; NEUROLOGIC DISEASE; PERIPHERAL NEUROPATHY; PROGNOSIS; RASH; REVIEW; STEROID THERAPY; SYSTEMATIC REVIEW; BLOOD; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; DRUG EFFECTS; FATIGUE SYNDROME, CHRONIC; HUMAN PARVOVIRUS B19; ISOLATION AND PURIFICATION; PARVOVIRIDAE INFECTIONS; PATHOPHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSIOLOGY; VIROLOGY;

ANTIBODIES, VIRAL; CENTRAL NERVOUS SYSTEM; DIAGNOSIS, DIFFERENTIAL; DNA, VIRAL; ENCEPHALITIS; FATIGUE SYNDROME, CHRONIC; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; PARVOVIRIDAE INFECTIONS; PARVOVIRUS B19, HUMAN; PERIPHERAL NERVOUS SYSTEM DISEASES; STEROIDS;

EID: 84898828893     PISSN: 10529276     EISSN: 10991654     Source Type: Journal    
DOI: 10.1002/rmv.1782     Document Type: Review

References (107)

1. Cossart YE, Field AM, Cant B, Widdows D. Parvovirus-like particles in human sera. Lancet 1975; 1: 72-73.
2. Barah F, Vallely PJ, Cleator GM, Kerr JR. Neurological manifestations of human parvovirus B19 infection. Reviews in Medical Virology 2003; 13: 185-199.
3. st, 2013).
4. Carruthers BM, van de Sande MI, De Meirleir KL, et al. Myalgic encephalomyelitis: international consensus criteria. Journal of Internal Medicine (2011); 270: 327-338.
5. Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Journal of Clinical Epidemiology 2009; 62: 1006-1012.
6. Balfour HH, Schiff GM, Bloom JE. Encephalitis associated with erythema infectiosum. Journal of Pediatrics 1970; 77: 133-136.
7. Breese C, Homer FA. Encephalopathy with erythema infectiosum. American Journal of Diseases of Children 1977; 131: 65-67.
8. Zerbini M, Musiani M, Venturoli S, et al. Different syndromes associated with parvovirus viraemia in paediatric patients: report of four cases. European Journal of Pediatrics 1992; 151: 815-817.
9. Watanabe T, Satoh M, Oda Y. Human parvovirus B19 encephalopathy. Archives of Disease in Childhood 1994; 70: 71.
10. Watanabe T. Ulcerative colitis that developed 8years after human parvovirus B19 encephalopathy. European Journal of Pediatrics 2004; 163: 341-342.
11. Yoto Y, Kudoh T, Asanuma H, et al. Transient disturbance of consciousness and hepatic dysfunction associated with human parvovirus B19 infection. Lancet 1994; 344: 624-625.
12. Heegaard ED, Peterslund NA, Homsleth A. Parvovirus B19 infection associated with encephalitis in a patient suffering from malignant lymphoma. Scandinavian Journal of Infectious Diseases 1995; 27: 631-633.
13. Umene K, Nunoue T. A new genome type of human parvovirus B19 present in sera of patients with encephalopathy. Journal of General Virology 1995; 76: 2645-2651.
14. Haseyama K, Kudoh T, Yoto Y, Suzuki N, Chiba S. Detection of human parvovirus B19 DNA in cerebrospinal fluid. Pediatric Infectious Disease Journal 1997; 16: 324-326.
15. Druschky K, Walloch J, Heckmann J, et al. Chronic parvovirus B19 meningoencephalitis with additional detection of Epstein-Bar virus DNA in the cerebrospinal fluid of an immunocompetent patient. Journal of NeuroVirology 2000; 6: 418-422.
16. Barah F, Vallely PJ, Chiswick ML, Cleator GM, Kerr JR. Human parvovirus B19 infection associated with acute meningoencephalitis. Lancet 2001; 358: 729-730.
17. Gennery AJ, Cant A, Forsyth RJ. Development of parainfectious opsoclonus in an infant by a non-humoral immune mechanism. Developmental Medicine and Child Neurology 2001; 43: 213-214.
18. Skaff PT, Labiner DM. Status epilepticus due to human parvovirus B19 encephalitis in an immunocompetent adult. Neurology 2001; 57: 1336-1337.
19. Wierenga KJ, Serjeant BE, Serjeant GR. Cerebrovascular complications and parvovirus infection in homozygous sickle cell disease. Journal of Pediatrics 2001; 139: 438-442.
20. Yazawa S, Kawasaki S, Fujimoto C, Ohi T. Case report of meningoencephalitis during a concomitant mumps and parvovirus B19 infection. Clinical Neurology and Neurosurgery 2002; 104: 380-382.
21. Bakhshi S, Sarnaik SA, Becker C, Shurney WW, Nigro M, et al. Acute encephalopathy with parvovirus B19 infection in sickle cell disease. Archives of Disease in Childhood 2002; 87: 541-542.
22. Nolan RC, Chidlow G, French MA. Parvovirus B19 encephalitis presenting as immune restoration disease after highly active antiretroviral therapy for human immunodeficiency virus infection. Clinical Infectious Diseases 2003; 36: 1191-1194.
23. Bilge I, Sadikoglu B, Emre S, et al. Central nervous system vasculitis secondary to parvovirus B19 infection in a pediatric renal transplant patient. Pediatric Nephrology 2005; 20: 529-533.
24. Erol I, Alehan F, Yalcin K. Refractory status epilepticus owing to human parvovirus B19 encephalitis in a child. Journal of Child Neurology 2006; 21: 820-822.
25. Fong CY, de Sousa C. Childhood chorea-encephalopathy associated with human parvovirus B19 infection. Developmental Medicine and Child Neurology 2006; 48: 526-528.
26. Laurenz M, Winkelmann B, Roigas J, et al. Severe parvovirus B19 encephalitis after renal transplantation. Pediatric Transplantation 2006; 10: 978-981.
27. Steinfort DP, Dixon B. Parvovirus encephalitis and pneumonia in an immunocompetent adult. Internal Medicine Journal 2006; 36: 209-210.
28. Tonnellier M, Bessereau J, Carbonnell N, et al. A possible parvovirus B19 encephalitis in an immunocompetent adult patient. Journal of Clinical Virology 2007; 38: 186-187.
29. Giørtz-Carlsen B, Rittig S, Thelle T. Neurological symptoms and acute hepatitis associated with parvovirus B19. Ugeskrift for Laeger 2007; 169: 4075-4077.
30. Bonvicini F, Marinacci G, Pajno MC, et al. Meningoencephalitis with persistent parvovirus B19 infection in an apparently healthy woman. Clinical Infectious Diseases 2008; 47: 385-387.
31. Oshima K, Kikuchi A, Mochizuki S, et al. Acute encephalopathy with human parvovirus B19 infection in hereditary spherocytosis. Pediatric Infectious Disease Journal 2008; 27: 651-652.
32. Moretti MV, Abbate I, Sciarrone MR, et al. Acute infection with parvovirus B19 manifesting as brain stem encephalitis. Infections in Medicine 2008; 25: 173-179.
33. Coskun O, Erdem H, Gul HC, et al. Meningoencephalitis associated with human parvovirus B19. Clinical Microbiology and Infection 2008; 14: 1188-1190.
34. Greco F, Barbagallo ML, Chiodo DC, Guglielmino R, Sorge G. Severe ataxia as a complication of human parvovirus B19 acute encephalitis in a child. Journal of Child Neurology 2008; 23: 1078-1080.
35. Grillo E, da Silva RJ. Childhood chorea-encephalopathy and unremarkable MRI: an association suggesting parvovirus B19 infection. Developmental Medicine and Child Neurology 2009; 51: 759-761.
36. Melbourne Chambers RH, Gooden MA, Gilbert TD, Jackson ST. Childhood chorea-encephalopathy associated with recent parvovirus B19 infection in two Jamaican children. Annals of Tropical Paediatrics 2010; 30: 339-344.
37. Cugler T, Carvalho LM, Facincani I, et al. Severe glomerulonephritis and encephalopathy associated with parvovirus B19 infection mimicking systemic lupus erythematosus. Scandinavian Journal of Rheumatology 2012; 41: 79-81.
38. Meyer P, Jeziorski E, Bott-Gilton L, et al. Childhood parvovirus B19 encephalitis. Archives of Pediatrics 2011; 18: 1315-1319.
39. Uchida Y, Matsubara K, Morio T, et al. Acute cerebellitis and concurrent encephalitis associated with parvovirus B19 infection. Pediatric Infectious Disease Journal 2012; 31: 427.
40. Lefrere J, Oliver C, Courouce AM, Soulier JP. Erythroblastopenia and febrile meningeal syndrome. Presse Médicale 1985; 14: 228-229.
41. Tsuji A, Uchida N, Asamura S, Matsunaga Y, Yamazaki S. Aseptic meningitis with erythema infectiosum. European Journal of Pediatrics 1990; 149: 449-450.
42. Okumura A, Ichikawa T. Aseptic meningitis caused by human parvovirus B19. Archives of Disease in Childhood 1993; 68: 784-785.
43. Cassinotti P, Schultze D, Schlageter P, Chevili S, Siegl G. Persistent human parvovirus B19 infection following an acute infection with meningitis in an immunocompetent patient. European Journal of Clinical Microbiology and Infectious Diseases 1993; 12: 701-704.
44. Suzuki N, Terada S, Inoue M. Neonatal meningitis with human parvovirus B19 infection. Archives of Disease in Childhood - Fetal and Neonatal Edition 1995; 73: F196-F197.
45. Koduri PR, Naides SJ. Aseptic meningitis caused by parvovirus B19. Clinical Infectious Diseases 1995; 21: 1053.
46. Tabak F, Mert A, Ozturk R, et al. Prolonged fever caused by parvovirus B19-induced meningitis: case report and review. Clinical Infectious Diseases 1999; 29: 446-447.
47. Sinclair JP, Croxson MC, Thomas SM, Teague LR, Mauger DC. Chronic parvovirus B19 meningitis in a child with acute lymphocytic leukemia. Pediatric Infectious Disease Journal 1999; 18: 395-396.
48. Pereira AC, Barros RA, do Nascimento JP, de Oliveira SA. Two family members with a syndrome of headache and rash caused by human parvovirus B19. Brazilian Journal of Infectious Diseases 2001; 5: 37-39.
49. Akin M, Carman KB, Karaturk AH, Ceran O. Mumps-like syndrome owing to parvovirus B19: a brief report. Annals of Tropical Paediatrics 2002; 22: 57-58.
50. Shimizu Y, Ueno T, Komatsu H, Takada H, Nunoue T. Acute cerebelar ataxia with human parvovirus B19 infection. Archives of Disease in Childhood 1999; 80: 72-73.
51. Guidi B, Bergonzini P, Crisi G, Frigieri G, Portolani M. Case of stroke in a 7-year-old male after parvovirus B19 infection. Pediatric Neurology 2003; 28: 69-71.
52. Mandrioli J, Portolani M, Cortelli P, Sola P. Middle cerebral artery thrombosis in course of parvovirus B19 infection in a young adult: a new risk factor for stroke? Journal of Neurovirology 2004; 10: 71-74.
53. Nagahama Y, Shimohama S, Kaji R, Akiguchi I, Kimura J. An adult case of transverse myelitis with erythema infectiosum. Rinshō Shinkeigaku 1992; 32: 1035-1037.
54. Earl SC, Zhang B, Thomas LM, Ledingham JM. A case of reactive arthritis secondary to parvovirus B19 infection complicated by an acute transverse myelitis. Rheumatology 2007; 46: i139.
55. Scheibe F, Hofmann J, Ruprecht K. Parainfectious myelitis associated with parvovirus B19 infection. Journal of Neurology 2010; 257: 1557-1558.
56. Nigro G, D'Eufemia P, Zerbini M, et al. Parvovirus B19 infection in a hypogammaglobulinemic infant with neurologic disorders and anemia: successful immunoglobulin therapy. Pediatric Infectious Disease Journal 1994; 13: 1019-1021.
57. Hsu D, Sandborg C, Hahn JS. Frontal lobe seizures and uveitis associated with acute human parvovirus B19 infection. Journal of Child Neurology 2004; 19: 304-306.
58. Kamlesh Y, Pallav G, Manjula M, Rohan M. Seizure and hepatosplenomegaly-rare manifestation of parvovirus B-19: a case report and review of the literature. Journal of Tropical Medicine 2011; 2011: 287914.
59. Yamazaki S, Ikeno K, Abe T, Tohyama J, Adachi Y. Hemiconvulsion-hemiplegia-epilepsy syndrome associated with CACNA1A S218L mutation. Pediatric Neurology 2011; 45: 193-196.
60. Costa PS, Ribeiro GM, Vale TC, Casali TG, Leite FJ. Adult Reye-like syndrome associated with serologic evidence of acute parvovirus B19 infection. Brazilian Journal of Infectious Diseases 2011; 15: 482-483.
61. Denning D, Amos A, Rudge P, Cohen B. Neuralgic amytrophy due to parvovirus infection. Journal of Neurology, Neurosurgery, and Psychiatry 1986; 50: 641-642.
62. Walsh KJ, Armstrong RD, Turner AM. Brachial plexus neuropathy associated with human parvovirus infection. British Medical Journal 1988; 296: 896.
63. Pellas F, Olivares JP, Zandotti C, Delarque A. Neuralgic amytrophy after parvovirus B19 infection. Lancet 1993; 342: 503-504.
64. Staud R, Davidson RA, Corman LC. Brachial plexitis in a patient with acute parvovirus B19 infection. British Journal of Rheumatology 1995; 34: 480-481.
65. Maas JJ, Beersma MF, Haan J, Jonkers GJ, Kroes AC. Bilateral brachial plexus neuritis following parvovirus B19 and cytomegalovirus infection. Annals of Neurology 1996; 40: 928-932.
66. Puechal X, Hilliquin P, Kahan A, Menkes CJ. Neuralgic amyotrophy and polyarthritis caused by parvovirus B 19 infection. Annals of the Rheumatic Diseases 1998; 57: 262.
67. Kirchhoff-Moradpour A, Huzly D, Korinthenberg R, Bener R. Neuralgic amytrophy associated with parvovirus B19 infection in a child. European Journal of Pediatrics 2001; 160: 200-201.
68. Serrano-Pozo A, Carrillo-García F, Montes-Latorre E, Gómez-Aranda F. Bilateral neuralgic amyotrophy secondary to parvovirus B19 infection. Medicina Clínica (Barcelona) 2006; 127: 398.
69. Faden H, Gary GW, Korman M. Numbness and tingling of fingers associated with parvovirus B19 infection. Journal of Infectious Diseases 1990; 161: 354-355.
70. Faden H, Gary GW Jr, Anderson LJ. Chronic parvovirus infection in a presumably immunologically healthy woman. Clinical Infectious Diseases 1992; 15: 595-597.
71. Rabar D, Peyramond D. Parvovirus B19 infection revealed by prolonged dysesthesia. Médecine et Maladies Infectieuses 2005; 35: 91-94.
72. Corman LC, Dolson DJ. Polyarteritis nodosa and parvovirus B19 infection. Lancet 1992; 339: 491.
73. Viguier M, Guillevin L, Laroche L. Treatment of parvovirus B19-associated polyarteritis nodosa with intravenous immune globulin. New England Journal of Medicine 2001; 344: 1481-1482.
74. Aguilar-Bernier M, Bassas-Vila J, Torné-Gutiérrez JI, et al. (2006) Presence of perineuritis in a case of papular purpuric gloves and socks syndrome associated with mononeuritis multiplex attributable to B19 parvovirus. Journal of the American Academy of Dermatology 54: 896-899.
75. Lenglet T, Haroche J, Schnuriger A, et al. (2011) Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome. Journal of Neurology 258: 1321-1326.
76. Hanai S, Komaki H, Sakuma H, et al. Acute autonomic sensory and motor neuropathy associated with parvovirus B19 infection. Brain Dev 2011; 33: 161-165.
77. Martinón-Torres F, Seara MJ, Del Río Pastoriza I, Mata MB, Castro-Gago M. Parvovirus B19 infection complicated by peripheral facial palsy and parotitis with intraparotid lymphadenitis. Pediatric Infectious Disease Journal 1999; 18: 307-308.
78. Soares-Fernandes JP, Maré R. Isolated velopalatine paralysis associated with parvovirus B19 infection. Arquivos de Neuro-Psiquiatria 2006; 64: 603-605.
79. Wilhelm H, Hartmann C, Boesche-Abele V. Optic neuropathy after erythema infectiosum. Klinische Monatsblätter für Augenheilkunde 1998; 213: 355-357.
80. Le Scanff J, Vighetto A, Mekki Y, et al. Acute ophthalmoparesis associated with human parvovirus B19 infection. European Journal of Ophthalmology 2010; 20: 802-804.
81. Samii K, Cassinotti P, de Freudenreich J, et al. Acute bilateral carpal tunnel syndrome associated with human parvovirus B19 infection. Clinical Infectious Diseases 1996; 22: 162-164.
82. Gendi NS, Gibson K, Wordsworth BP. Effect of HLA type and hypocomplementaemia on the expression of parvovirus arthritis: one year follow up of an outbreak. Annals of the Rheumatic Diseases 1996; 55: 63-65.
83. Kerr JR, Bracewell J, Laing I, et al. Chronic fatigue syndrome and arthralgia following parvovirus B19 infection. Journal of Rheumatology 2002; 29: 595-602.
84. Musiani M, Manaresi E, Gallinella G, Zerbini M. Persistent parvovirus b19 infection resulting in carpal tunnel syndrome. Journal of Clinical Pathology 2007; 60: 1177-1178.
85. de Paula JMP, Mayor-Toranzo E, Franco-Hidalgo S. Bilateral carpal tunnel syndrome and parvovirus B19 infection. Revista Clínica Española 2012; 212: 221-222.
86. Minohara Y, Koitabashi Y, Kato T, et al. A case of Guillain-Barré syndrome associated with human parvovirus B19 infection. Journal of Infection 1998; 36: 327-328.
87. Yamaoka Y, Isozaki E, Kagamihara Y, et al. A case of Guillain-Barré syndrome (GBS) following human parvovirus B19 infection. Rinshō Shinkeigaku 2000; 40: 471-475.
88. Barbi F, Ariatti A, Funakoshi K, et al. Parvovirus B19 infection antedating Guillain-Barré syndrome variant with prominent facial diplegia. Journal of Neurology 2011; 258: 1551-1552.
89. Bucher Praz C, Dessimoz C, Bally F, Reymond S, Troillet N. Guillain-Barré syndrome associated with primary parvovirus B19 infection in an HIV-1-infected patient. Medical Case Reports 2012; 2012: 140780.
90. Kerr JR, Coyle PV, DeLeys RJ, Patterson CC. Follow-up study of clinical and immunological findings in patients presenting with acute parvovirus B19 infection. Journal of Medical Virology 1996; 48: 68-75.
91. Kerr JR, Cunniffe VS. Antibodies to parvovirus B19 non-structural protein are associated with chronic but not acute arthritis following B19 infection. Rheumatology 2000; 39: 903-908.
92. Jacobson SK, Daly JS, Thorne GM, McIntosh K. Chronic parvovirus B19 infection resulting in chronic fatigue syndrome: case history and review. Clinical Infectious Diseases 1997; 24: 1048-1051.
93. Matano S, Kinoshita H, Tanigawa K, Terahata S, Sugimoto T. Acute parvovirus B19 infection mimicking chronic fatigue syndrome. Internal Medicine 2003; 42: 903-905.
94. McGhee SA, Kaska B, Liebhaber M, Stiehm ER. Persistent parvovirus-associated chronic fatigue treated with high dose intravenous immunoglobulin. Pediatric Infectious Disease Journal 2005; 24: 272-274.
95. Jmor F, Emsley HC, Fischer M, Solomon T, Lewthwaite P. The incidence of acute encephalitis syndrome in Western industrialised and tropical countries. Virology Journal 2008; 5: 134.
96. Heegaard ED, Brown KE. Human parvovirus B19. Clinical Microbiology Reviews 2002; 15: 485-505.
97. Kerr JR, Barah F, Chiswick ML, et al. Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae. Journal of Neurology, Neurosurgery, and Psychiatry 2002; 73: 739-746.
98. Isumi H, Nunoue T, Nishida A, Takashima S. Fetal brain infection with human parvovirus B19. Pediatric Neurology 1999; 21: 661-663.
99. Hobbs JA. Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex. Journal of Neurovirology 2006; 12: 190-199.
100. Grant JK, Yin NC, Zaytoun AM, Waseem H, Hobbs JA. Persistent adeno-associated virus 2 and parvovirus B19 sequences in post-mortem human cerebellum. Cerebellum 2009; 8: 490-498.
101. Grillo E, da Silva RJ .Anti-N-methyl-d-aspartate receptor encephalitis and parvovirus B19: a possible link? Journal of Pediatrics 2013; 163: 1233-1234.
102. Dua K, Banerjee A. Guillain-Barré syndrome: a review. British Journal of Hospital Medicine 2010; 71: 495-498.
103. Winer JB, Hughes RA, Anderson MJ, et al. A prospective study of acute idiopathic neuropathy II. Antecedent events. Journal of Neurology, Neurosurgery, and Psychiatry 1988; 51: 613-618.
104. Ilaria RL Jr, Komaroff AL, Fagioli LR, et al. Absence of parvovirus B19 infection in chronic fatigue syndrome. Arthritis and Rheumatism 1995; 38: 638-641.
105. Koelle DM, Barcy S, Huang ML, et al. Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome. Clinical Infectious Diseases 2002; 35: 518-525.
106. Kerr JR, Gough J, Richards SC, et al. Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis. Journal of General Virology 2010; 91: 893-897.
107. Kerr JR, Cunniffe VS, Kelleher P, Bernstein RM, Bruce IN. Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome. Clinical Infectious Diseases 2003; 36: e100-e106.