Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis

Journal of General Virology

Volumn 91, Issue 4, 2010, Pages 893-897

  Kerr, Jonathan R ^a   Gough, John ^a   Richards, Selwyn C M ^b   Main, Janice ^c   Enlander, Derek ^d   McCreary, Michelle ^e   Komaroff, Anthony L ^e   Chia, John K ^f  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b POOLE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^c ST MARY S HOSPITAL   (United Kingdom)

^d New York ME/CFS Service   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f ID Med   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MARKER; NONSTRUCTURAL PROTEIN 1 ANTIBODY; PROTEIN VP2; PROTEIN VP2 ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ADULT; ARTHRALGIA; ARTICLE; BLOOD DONOR; BLOOD SAMPLING; CHRONIC FATIGUE SYNDROME; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE DURATION; DIZZINESS; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHEMA INFECTIOSUM; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; IMMUNOFLUORESCENCE; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALAISE; MALE; MEMORY DISORDER; MYALGIA; PARESTHESIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEROPREVALENCE; SHORT FORM 36; SLEEP DISORDER; SORE THROAT; SYNCOPE; VIRUS DETECTION;

ADULT; ANTIBODIES, VIRAL; ARTHRALGIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CHRONIC DISEASE; FATIGUE SYNDROME, CHRONIC; FEMALE; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; HUMANS; MALE; PARVOVIRUS B19, HUMAN; VIRAL NONSTRUCTURAL PROTEINS;

PARVOVIRUS;

EID: 77949511559     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.017590-0     Document Type: Article

References (30)

1. Astell, C. R., Weixing, L., Brunstein, J. & Amand, J. S. (1997). The genome of B19 parvovirus. In Human Parvovirus B19. Monographs in Virology, vol. 20, pp. 16-41. Edited by L. J. Anderson & N. S. Young. New York: Karger.
2. Chalder, T., Berelowitz, G., Pawlikowska, T., Watts, L., Wessely, S., Wright, D. & Wallace, E. P. (1993). Development of a fatigue scale. J Psychosom Res 37, 147-153.
3. Devanur, L. D. & Kerr, J. R. (2006). Chronic fatigue syndrome. J Clin Virol 37, 139-150.
4. Fu, Y., Ishii, K. K., Munakata, Y., Saitoh, T., Kaku, M. & Sasaki, T. (2002). Regulation of tumor necrosis factor alpha promoter by human parvovirus B19 NS1 through activation of AP-1 and AP-2. J Virol 76, 5395-5403.
5. Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G. & Komaroff, A. (1994). The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 121, 953-959.
6. Gareus, R., Gigler, A., Hemauer, A., Leruez-Ville, M., Morinet, F., Wolf, H. & Modrow, S. (1998). Characterization of cis-acting and NS1-responsive elements in the p6 promoter of parvovirus B19. J Virol 72, 609-616.
7. Hemauer, A., Modrow, S., Georgi, J., Helmke, K., Veith, P., Lang, B., Schölmerich, J. & Straub, R. H. (1999). There is no association between polymyalgia rheumatica and acute parvovirus B19 infection. Ann Rheum Dis 58, 657.
8. Hemauer, A., Gigler, A., Searle, K., Beckenlehner, K., Raab, U., Broliden, K., Enders, G. & Modrow, S. (2000). Seroprevalence of parvovirus B19 NS1-specific IgG in B19-infected and uninfected individuals and in infected pregnant women. J Med Virol 60, 48-55.
9. Hicks, K. E., Cubel, R. C., Cohen, B. J. & Clewley, J. P. (1996). Sequence analysis of a parvovirus B19 isolate and baculovirus expression of the non-structural protein. Arch Virol 141, 1319-1327.
10. Kaushik, N., Fear, D., Richards, S. C., McDermott, C. R., Nuwaysir, E. F., Kellam, P., Harrison, T. J., Wilkinson, R. J., Tyrrell, D. A. & other authors (2005). Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome. J Clin Pathol 58, 826-832.
11. Kerr, J. R. & Cunniffe, V. S. (2000). Antibodies to parvovirus B19 nonstructural protein are associated with chronic but not acute arthritis following B19 infection. Rheumatology 39, 903-908.
12. Kerr, J. R. & Modrow, S. (2006). Human parvovirus B19. In The Parvoviruses, pp. 385-416. Edited by J. R. Kerr, S. F. Cotmore, M. E. Bloom, M. Linden & C. R. Parrish. London: Hodder Arnold.
13. Kerr, J. R., Barah, F., Mattey, D. L., Laing, I., Hopkins, S. J., Hutchinson, I. V. & Tyrrell, D. A. (2001). Circulating tumour necrosis factor-α and interferon-γ are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue. J Gen Virol 82, 3011-3019.
14. Kerr, J. R., Bracewell, J., Laing, I., Mattey, D. L., Bernstein, R. M., Bruce, I. N. & Tyrrell, D. A. (2002). Chronic fatigue syndrome and arthralgia following parvovirus B19 infection. J Rheumatol 29, 595-602.
15. Kerr, J. R., Cunniffe, V. S., Kelleher, P., Bernstein, R. M. & Bruce, I. N. (2003). Successful intravenous immunoglobulin (IVIG) therapy in parvovirus B19-associated chronic fatigue syndrome (CFS). Clin Infect Dis 36, e100-e106.
16. Kerr, J. R., Kaushik, N., Fear, D., Baldwin, D. A., Nuwaysir, E. F. & Adcock, I. M. (2005). Single nucleotide polymorphisms (SNPs) associated with symptomatic infection and differential human gene expression in seropositive persons implicate the cytoskeleton, integrin signalling and oncosuppression in the pathogenesis of human parvovirus B19 infection. J Infect Dis 192, 276-286.
17. Kerr, J. R., Petty, R., Burke, B., Gough, J., Fear, D., Sinclair, L. I., Mattey, D. L., Richards, S. C., Montgomery, J. & other authors (2008). Gene expression subtypes of chronic fatigue syndrome/ myalgic encephalomyelitis. J Infect Dis 197, 1171-1184.
18. Komaroff, A. L. & Buchwald, D. (1998). Chronic fatigue syndrome: an update. Annu Rev Med 49, 1-13.
19. Lehmann, H. W., Kühner, L., Beckenlehner, K., Müller-Godeffroy, E., Heide, K. G., Küster, R. M. & Modrow, S. (2002). Chronic human parvovirus B19 infection in rheumatic disease of childhood and adolescence. J Clin Virol 25, 135-143.
20. Moffatt, S., Tanaka, N., Tada, K., Nose, M., Nakamura, M., Muraoka, O., Hirano, T. & Sugamura, K. (1996). A cytotoxic nonstructural protein, NS1, of human parvovirus B19 induces activation of interleukin-6 gene expression. J Virol 70, 8485-8491.
21. Papanicolaou, D. A., Amsterdam, J. D., Levine, S., McCann, S. M., Moore, R. C., Newbrand, C. H., Allen, G., Nisenbaum, R., Pfaff, D. W. & other authors (2004). Neuroendocrine aspects of chronic fatigue syndrome. Neuroimmunomodulation 11, 65-74.
22. Raab, U., Bauer, B., Gigler, A., Beckenlehner, K., Wolf, H. & Modrow, S. (2001). Cellular transcription factors that interact with the p6 promoter elements of parvovirus B19. J Gen Virol 82, 1473-1480.
23. Raab, U., Beckenlehner, K., Lowin, T., Niller, H. H., Doyle, S. & Modrow, S. (2002). NS1-protein of parvovirus B19 interacts directly with DNA sequences of the p6-promoter and with cellular transcription factors Sp1/Sp3. Virology 293, 86-93.
24. Reeves, W. C., Lloyd, A., Vernon, S. D., Klimas, N., Jason, L. A., Bleijenberg, G., Evengard, B., White, P. D., Nisenbaum, R. & Unger, E. R. (2003). Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res 3, 25.
25. Report of the CFS/ME Working Group (2002). Department of Health, January 2002 (http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/ PublicationsPolicyAndGuidance/DH-4064840).
26. Searle, K., Schalasta, G. & Enders, G. (1998). Development of antibodies to the nonstructural protein NS1 of parvovirus B19 during acute symptomatic and subclinical infection in pregnancy: implications for pathogenesis doubtful. J Med Virol 56, 192-198.
27. Vassias, I., Hazan, U., Michel, Y., Sawa, C., Handa, H., Gouya, L. & Morinet, F. (1998). Regulation of human B19 parvovirus promoter expression by hGABP (E4TF1) transcription factor. J Biol Chem 273, 8287-8293.
28. von Poblotzki, A., Hemauer, A., Gigler, A., Puchhammer-Stöckl, E., Heinz, F. X., Pont, J., Laczika, K., Wolf, H. & Modrow, S. (1995a). Antibodies to the nonstructural protein of parvovirus B19 in persistently infected patients: implications for pathogenesis. J Infect Dis 172, 1356-1359.
29. von Poblotzki, A., Gigler, A., Lang, B., Wolf, H. & Modrow, S. (1995b). Antibodies to parvovirus B19 NS-1 protein in infected individuals. J Gen Virol 76, 519-527.
30. Zhang, L., Gough, J., Christmas, D., Mattey, D. L., Richards, S. C. M., Enlander, D., Honeybourne, D., Ayres, J. G., Nutt, D. J. & Kerr, J. R. (2010). Microbial infections in eight genomic subtypes of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). J Clin Pathol (in press).