Etiology, clinical outcome, and laboratory features in children with neutropenia: Analysis of 104 cases

Pediatric Allergy and Immunology

Volumn 25, Issue 3, 2014, Pages 283-289

  Angelino, Giulia ^a   Caruso, Roberta ^a   D'Argenio, Patrizia ^a   Calò Carducci, Francesca Ippolita ^a   Pascone, Roberto ^b   Lanciotti, Marina ^c   Cancrini, Caterina ^a   Palma, Paolo ^a   Aiuti, Alessandro ^a   Rossi, Paolo ^a   Finocchi, Andrea ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c G GASLINI INSTITUTE   (Italy)

Author keywords

Acute neutropenia; Autoimmune neutropenia; Children; Chronic idiopathic neutropenia; Congenital neutropenia; Post infectious neutropenia; Severe congenital neutropenia

Indexed keywords

ACUTE DISEASE; ACUTE NEUTROPENIA; ADOLESCENT; ARTICLE; AUTOIMMUNE NEUTROPENIA; CHILD; CHILDHOOD DISEASE; CHRONIC DISEASE; CHRONIC IDIOPATHIC NEUTROPENIA; CLINICAL EXAMINATION; CLINICAL FEATURE; COHORT ANALYSIS; CONVALESCENCE; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HUMAN; INFECTION COMPLICATION; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; PRIORITY JOURNAL; REMISSION; SEVERE CONGENITAL NEUTROPENIA; INFANT; PRESCHOOL CHILD;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; NEUTROPENIA;

EID: 84898824426     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12177     Document Type: Article

References (24)

1. Segel GB, Halterman JS. Neutropenia in pediatric practice. Pediatr Rev 2008: 29: 12-23.
2. Srdjan D, Saad S. Prevalence, phenotype and inheritance of benign neutropenia in Arabs. BMC Blood Disord 2009: 9: 3.
3. Haddy TB, Rana SR, Castro O. Benign ethnic neutropenia: what is a normal absolute neutrophil count? J Lab Clin Med 1999: 133: 15-22.
4. Alexandropoulou O, Kossiva L, Haliotis F, et al. Transient neutropenia in children with febrile illness and associated infectious agents: 2 years' follow-up. Eur J Pediatr 2013: 172: 811-9.
5. Wan C, Yu HH, Lu MY, et al. Clinical manifestations and outcomes of pediatric chronic neutropenia. J Formos Med Assoc 2012: 111: 220-7.
6. Karavanaki K, Polychronopoulou S, Giannaki M, et al. Transient and chronic neutropenias detected in children with different viral and bacterial infections. Acta Paediatr 2006: 95: 565-72.
7. Chung BHY, Chan GCF, Lee TL, et al. Chronic benign neutropenia among Chinese children. Hong Kong Med J 2004: 10: 231-6.
8. Bernini JC. Diagnosis and management of chronic neutropenia during childhood. Pediatr Clin North Am 1996: 43: 773-92.
9. Capsoni F, Sarzi Puttini P, Zanella A. Primary and secondary autoimmune neutropenia. Arthritis Res Ther 2005: 7: 208-14.
10. Perez-Mendez C, Molinos-Norniella C, Moran-Poladura M, Fernandez-Rodríguez E, Suarez-Castanon C, Solís-Sanchez G. Low risk of bacteremia in otherwise healthy children presenting with fever and severe neutropenia. Pediatr Infect Dis J 2010: 29: 671-2.
11. Vlacha V, Feketea G. The clinical significance of non-malignant neutropenia in hospitalized children. Ann Hematol 2007: 86: 865-70.
12. Yilmaz D, Ritchey AK. Severe neutropenia in children: a single institutional experience. J Pediatr Hematol Oncol 2007: 29: 513-8.
13. Alario AJ. Management of the febrile, otherwise healthy child with neutropenia. Pediatr Infect Dis J 1994: 13: 169-70.
14. Bonadio WA, Smith DS, Mathews S, Rock A. Clinical significance of newly documented neutropenia in febrile young infants evaluated for sepsis. Pediatr Infect Dis J 1991: 10: 407-8.
15. Pizzo PA. Management of fever in patients with cancer and treatment-induced neutropenia. N Engl J Med 1993: 328: 1323-32.
16. Fioredda F, Calvillo M, Bonanomi S, et al. Congenital and acquired neutropenia consensus guidelines on diagnosis from the Neutropenia Committee of the Marrow Failure Syndrome Group of the AIEOP (Associazione Italiana Emato-Oncologia Pediatrica). Pediatr Blood Cancer 2011: 57: 10-7.
17. Dale DC, Bolyard AA, Schwinzer BG, et al. The severe chronic neutropenia international registry: 10-Year follow-up report. Support Cancer Ther 2006: 3: 223-34.
18. Husain EH, Mullah-Ali A, Al-Sharidah S, Azab AF, Adekile A. Infectious etiologies of transient neutropenia in previously healthy children. Pediatr Infect Dis J 2012: 31: 575-7.
19. Audrain M, Martin J, Fromont P, Prié N, Thomas C, Muller EJ. Autoimmune neutropenia in children: analysis of 116 cases. Pediatr Allergy Immunol 2011: 22: 494-6.
20. Sella R, Flomenblit L, Goldstein I, Kaplinsky C. Detection of anti-neutrophil antibodies in autoimmune neutropenia of infancy: a multicenter study. Isr Med Assoc J 2010: 12: 91-6.
21. Sheen JM, Kuo HC, Yu HR, Huang EY, Wu CC, Yang KD. Prolonged acquired neutropenia in children. Pediatr Blood Cancer 2009: 53: 1284-8.
22. Taniuchi S, Masuda M, Hasui M, Tsuji S, Takahashi H, Kobayashi Y. Differential diagnosis and clinical course of autoimmune neutropenia in infancy: comparison with congenital neutropenia. Acta Paediatr 2002: 91: 1179-82.
23. Bux J. Human neutrophil antigens. Vox Sang 2008: 94: 277-85.
24. Palmblad J, Papadaki HA. Chronic idiopathic neutropenias and severe congenital neutropenia. Curr Opin Hematol 2008: 15: 8-14.