Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method

Drug Metabolism and Disposition

Volumn 42, Issue 5, 2014, Pages 899-902

  Ballard, T Eric ^a   Orozco, Christine C ^a   Obach, R Scott ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; CAPROMORELIN; CELECOXIB; DRUG METABOLITE; LINEZOLID; ZIPRASIDONE; DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG EXCRETION; DRUG METABOLISM; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CELL; MALE; OXIDATION; PERFORMANCE; PREDICTION; PRIORITY JOURNAL; BIOLOGICAL MODEL; CHEMISTRY; COCULTURE; CYTOLOGY; DRUG DETOXIFICATION; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; TANDEM MASS SPECTROMETRY;

CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCULTURE TECHNIQUES; HEPATOCYTES; HUMANS; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; TANDEM MASS SPECTROMETRY;

EID: 84898812420     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.057026     Document Type: Article

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