In vivo biofunctional evaluation of hydrogels for disc regeneration

European Spine Journal

Volumn 23, Issue 1, 2014, Pages 19-26

  Reitmaier, Sandra ^a   Kreja, Ludwika ^a   Gruchenberg, Katharina ^a   Kanter, Britta ^a   Silva Correia, Joana ^b   Oliveira, Joaquim Miguel ^b   Reis, Rui Luís ^b   Perugini, Valeria ^c   Santin, Matteo ^c   Ignatius, Anita ^a   Wilke, Hans Joachim ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF MINHO   (Portugal)

^c UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

Degeneration; In vivo; Intervertebral disc; Large animal model; One step; Regeneration; Sheep

Indexed keywords

GELLAN; HYALURONIC ACID; SEALANT; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; BIOMATERIAL; HYDROGEL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE MARROW DERIVED MONONUCLEAR CELL; CONTROLLED STUDY; HISTOLOGY; HYDROGEL; ILIAC CREST; IN VIVO STUDY; INTERVERTEBRAL DISK; MERINO SHEEP; MONONUCLEAR CELL; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; RANGE OF MOTION; TISSUE REGENERATION; ANIMAL; BONE MARROW TRANSPLANTATION; HUMAN; IN VITRO STUDY; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISKECTOMY; PHYSIOLOGY; REGENERATION; SHEEP; THERAPEUTIC USE; TRANSPLANTATION;

ADULT; ANGIOGENESIS INHIBITORS; ANIMALS; BIOCOMPATIBLE MATERIALS; BIOMECHANICAL PHENOMENA; BONE MARROW TRANSPLANTATION; DISKECTOMY, PERCUTANEOUS; HUMANS; HYALURONIC ACID; HYDROGELS; IN VITRO TECHNIQUES; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; LEUKOCYTES, MONONUCLEAR; REGENERATION; SHEEP;

EID: 84898804374     PISSN: 09406719     EISSN: 14320932     Source Type: Journal    
DOI: 10.1007/s00586-013-2998-8     Document Type: Article

References (52)

1. Adams MA, Roughley PJ (2006) What is intervertebral disc degeneration, and what causes it? Spine 31(18):2151-2161
2. Roberts S, Evans H, Trivedi J, Menage J (2006) Histology and pathology of the human intervertebral disc. J Bone Jt Surg Am 88(Suppl 2):10-14
3. Paesold G, Nerlich AG, Boos N (2007) Biological treatment strategies for disc degeneration: potentials and shortcomings. Euro Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc 16(4):447-468 (Pubitemid 46626252)
4. Kandel R, Roberts S, Urban JP (2008) Tissue engineering and the intervertebral disc: the challenges. Euro Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc 17(Suppl 4):480-491
5. Chan SC, Gantenbein-Ritter B (2012) Intervertebral disc regeneration or repair with biomaterials and stem cell therapy - feasible or fiction? Swiss medical weekly 142: w13598
6. Urban JP, Smith S, Fairbank JC (2004) Nutrition of the intervertebral disc. Spine 29(23):2700-2709 (Pubitemid 40353256)
7. Raj PP (2008) Intervertebral disc: anatomy-physiology-patho-physiology- treatment. Pain Pract Off J World Inst Pain 8(1):18-44
8. Johnson WE, Evans H, Menage J, Eisenstein SM, El Haj A, Roberts S (2001) Immunohistochemical detection of Schwann cells in innervated and vascularized human intervertebral discs. Spine 26(23):2550-2557 (Pubitemid 33134302)
9. Kauppila LI (1995) Ingrowth of blood vessels in disc degeneration. Angiographic and histological studies of cadaveric spines. J Bone Jt Surg Am 77(1):26-31
10. Ishihara H, McNally DS, Urban JP, Hall AC (1996) Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk. J Appl Physiol 80(3):839-846 (Pubitemid 26087247)
11. Neidlinger-Wilke C, Wurtz K, Urban JP, Borm W, Arand M, Ignatius A, Wilke HJ, Claes LE (2006) Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure. Euro Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc 15(Suppl 3):S372-S378 (Pubitemid 44371016)
12. Fernando HN, Czamanski J, Yuan TY, Gu W, Salahadin A, Huang CY (2011) Mechanical loading affects the energy metabolism of intervertebral disc cells. J Orthop Res Off Publ Orthop Res Soc 29(11):1634-1641
13. Chan SC, Ferguson SJ, Gantenbein-Ritter B (2011) The effects of dynamic loading on the intervertebral disc. Eur Spine J 20(11):1796-1812
14. Wilke HJ, Heuer F, Neidlinger-Wilke C, Claes L (2006) Is a collagen scaffold for a tissue engineered nucleus replacement capable of restoring disc height and stability in an animal model? Eur Spine J 15(Suppl 3):S433-S438 (Pubitemid 44371022)
15. Heuer F, Ulrich S, Claes L, Wilke HJ (2008) Biomechanical evaluation of conventional anulus fibrosus closure methods required for nucleus replacement. Laboratory investigation. J Neurosurg Spine 9(3):307-313
16. Vadala G, Sowa G, Hubert M, Gilbertson LG, Denaro V, Kang JD (2012) Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation. J Tissue Eng Regen Med 6(5):348-355
17. Revell PA, Damien E, Di Silvio L, Gurav N, Longinotti C, Ambrosio L (2007) Tissue engineered intervertebral disc repair in the pig using injectable polymers. J Mater Sci Mater Med 18(2):303-308 (Pubitemid 46332852)
18. Silva-Correia J, Miranda-Goncalves V, Salgado A, Sousa N, Oliveira JM, Reis RM, Reis RL (2012) Angiogenic potential of gellan gum-based hydrogels for application in nucleus pulposus regeneration: In vivo study. Tissue Eng. Part A
19. Silva-Correia J, Oliveira JM, Caridade SG, Oliveira JT, Sousa RA, Mano JF, Reis RL (2011) Gellan gum-based hydrogels for intervertebral disc tissue-engineering applications. J Tissue Eng Regen Med 5(6):e97-e107
20. Meikle ST, Perugini V, Guildford AL, Santin M (2011) Synthesis, characterisation and in vitro anti-angiogenic potential of dendron VEGF blockers. Macromol Biosci 11(12):1761-1765
21. Reitmaier S, Wolfram U, Ignatius A, Wilke HJ, Gloria A, Martinez JMM, Silva-Correia J, Oliveira JM, Reis RL, Schmidt H (2012) Hydrogels for nucleus replacement-facing the biomechanical challenge. J Mech Behav Biomed Mater
22. McCarty RC, Gronthos S, Zannettino AC, Foster BK, Xian CJ (2009) Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells. J Cell Physiol 219:324-333
23. Reitmaier S, Schmidt H, Ihler R, Kocak T, Graf N, Ignatius A, Wilke H-J (in press) Preliminary Investigations on Intradiscal Pressures During Daily Activities: An In Vivo Study Using The Merino Sheep. PloS one
24. Ahlgren BD, Lui W, Herkowitz HN, Panjabi MM, Guiboux JP (2000) Effect of anular repair on the healing strength of the intervertebral disc: a sheep model. Spine (Phila Pa 1976) 25(17):2165-2170
25. Wilke HJ, Claes L, Schmitt H, Wolf S (1994) A universal spine tester for in vitro experiments with muscle force simulation. Euro Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc 3(2):91-97 (Pubitemid 24099160)
26. Wilke HJ, Wenger K, Claes L (1998) Testing criteria for spinal implants: recommendations for the standardization of in vitro stability testing of spinal implants. Eur Spine J 7(2):148-154 (Pubitemid 28223601)
27. Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Nerlich AG (2002) Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 27(23):2631-2644 (Pubitemid 35425317)
28. 1.45s I (Wayne Rasband, National Institute of Health). Available at http://imagej.nih.gov/ij
29. Team RDC (2011) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. Available at http://www.R-project.org/
30. Wilke HJ, Kavanagh S, Neller S, Haid C, Claes LE (2001) Effect of a prosthetic disc nucleus on the mobility and disc height of the L4-5 intervertebral disc postnucleotomy. J Neurosurg 95(2 Suppl):208-214 (Pubitemid 33730839)
31. Hegewald AA, Knecht S, Baumgartner D, Gerber H, Endres M, Kaps C, Stussi E, Thome C (2009) Biomechanical testing of a polymer-based biomaterial for the restoration of spinal stability after nucleotomy. J Orthop Surg Res 4: 25
32. Melrose J, Roberts S, Smith S, Menage J, Ghosh P (2002) Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration. Spine 27(12):1278-1285 (Pubitemid 34655132)
33. Arthur A, Cannella M, Keane M, Singhatat W, Vresilovic E, Marcolongo M (2010) Fill of the nucleus cavity affects mechanical stability in compression, bending, and torsion of a spine segment, which has undergone nucleus replacement. Spine 35(11):1128-1135
34. Wilke HJ, Ressel L, Heuer F, Graf N, Rath S (2013) Can prevention of a reherniation be investigated? Establishment of a herniation model and experiments with an anular closure device. Spine 38(10):E587-E593
35. Buser Z, Kuelling F, Liu J, Liebenberg E, Thorne KJ, Coughlin D, Lotz JC (2011) Biological and biomechanical effects of fibrin injection into porcine intervertebral discs. Spine 36(18):E1201-E1209
36. Huang B, Zhuang Y, Li CQ, Liu LT, Zhou Y (2011) Regeneration of the intervertebral disc with nucleus pulposus cell-seeded collagen II/hyaluronan/chondroitin-6-sulfate tri-copolymer constructs in a rabbit disc degeneration model. Spine 36(26): 2252-2259
37. Hunter CJ, Matyas JR, Duncan NA (2004) Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison. J Anat 205(5):357-362 (Pubitemid 39642429)
38. Alini M, Eisenstein SM, Ito K, Little C, Kettler AA, Masuda K, Melrose J, Ralphs J, Stokes I, Wilke HJ (2008) Are animal models useful for studying human disc disorders/degeneration? Eur Spine J 17(1):2-19 (Pubitemid 351170127)
39. Reid JE, Meakin JR, Robins SP, Skakle JM, Hukins DW (2002) Sheep lumbar intervertebral discs as models for human discs. Clin Biomech (Bristol, Avon) 17(4): 312-314 (Pubitemid 34556762)
40. Beckstein JC, Sen S, Schaer TP, Vresilovic EJ, Elliott DM (2008) Comparison of animal discs used in disc research to human lumbar disc: axial compression mechanics and glycosaminoglycan content. Spine 33(6):E166-E173 (Pubitemid 351451735)
41. Wilke HJ, Kettler A, Claes LE (1997) Are sheep spines a valid biomechanical model for human spines? Spine 22(20):2365-2374 (Pubitemid 28069105)
42. Wilke HJ, Kettler A, Wenger KH, Claes LE (1997) Anatomy of the sheep spine and its comparison to the human spine. Anat Rec 247(4):542-555 (Pubitemid 27157430)
43. Serigano K, Sakai D, Hiyama A, Tamura F, Tanaka M, Mochida J (2010) Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model. J Orthop Res Off Publ Orthop Res Soc 28(10):1267-1275
44. Leung VY, Chan D, Cheung KM (2006) Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction. Euro Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc 15(Suppl 3):S406-S413 (Pubitemid 44371020)
45. Sheikh H, Zakharian K, De La Torre RP, Facek C, Vasquez A, Chaudhry GR, Svinarich D, Perez-Cruet MJ (2009) In vivo intervertebral disc regeneration using stem cell-derived chondroprogenitors. J Neurosurg Spine 10(3):265-272
46. Drazin D, Rosner J, Avalos P, Acosta F (2012) Stem cell therapy for degenerative disc disease. Adv Orthop 2012: 961052
47. Ren G, Chen X, Dong F, Li W, Ren X, Zhang Y, Shi Y (2012) Concise review: mesenchymal stem cells and translational medicine: emerging issues. Stem Cell Transl Med 1:51-58
48. Wang S, Qu X, Zhao RC (2012) Clinical applications of mesenchymal stem cells. J Hematol Oncol 5: 19. Available at http://www.jhoonline.org/content/15/ 11/19
49. Wen Z, Zheng S, Zhou C, Wang J, Wang T (2011) Repair mechanisms of bone marrow mesenchymal cells in myocardial infraction. J Cell Mol Med 15:1032-1043
50. Bernardo ME, Fibbe WE (2012) Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders. Ann NY Acad Sci 1266:107-117
51. Lepperdinger G, Brunauer R, Jamnig A, Laschober G, Kassem M (2008) Controversial issue: is it safe to employ mesenchymal stem cells in cell-based therapies? Exp Gerontol 43(11):1018-1023
52. So K, Takemoto M, Fujibayashi S, Neo M, Kyomoto M, Hayami T, Hyon SH, Nakamura T (2007) Antidegenerative effects of partial disc replacement in an animal surgery model. Spine 32(15):1586-1591 (Pubitemid 47051840)