Efficacy and safety of leflunomide in psoriatic arthritis

Journal of Pakistan Association of Dermatologists

Volumn 24, Issue 1, 2014, Pages 51-56

  Asaduzzaman, A T M ^a   Sikder, Akramullah ^a   Mahmud, Md Mostaque ^b   Paul, Harashit Kumar ^a   Islam, Md Nazrul ^a  

^a BANGABANDHU SHEIKH MUJIB MEDICAL UNIVERSITY   (Bangladesh)

^b SIR SALIMULLAH MEDICAL COLLEGE   (Bangladesh)

Author keywords

Leflunomide; Methotrexate; Psoriasis; Psoriatic arthritis

Indexed keywords

ALANINE AMINOTRANSFERASE; CREATININE; HEMOGLOBIN; IBUPROFEN; LEFLUNOMIDE; METHOTREXATE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALOPECIA; ARTHRALGIA; ARTICLE; ASTHENIA; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL EFFECTIVENESS; CLINICAL FEATURE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ACTIVITY; DISEASE DURATION; DIZZINESS; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DYSPEPSIA; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FOLLOW UP; GLOBAL ASSESSMENT OF FUNCTIONING; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; JOINT SWELLING; LEUKOCYTE COUNT; MALE; MORNING STIFFNESS; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NAUSEA; OPEN STUDY; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PSORIASIS AREA AND SEVERITY INDEX; PSORIATIC ARTHRITIS; PSORIATIC ARTHRITIS RESPONSE CRITERIA; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT; TREATMENT DURATION; TREATMENT RESPONSE; VISUAL ANALOG SCALE; VOMITING;

EID: 84898802713     PISSN: 15609014     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Shbeeb M, Uramoto KM, Gibson LE et al. The epidemiology of psoriatic arthritis in Olmsted County, Minnesota, USA, 1982-1991. J Rheumatol. 2000; 27:1247-50.
2. National Psoriasis Foundation. New research shows 1 million U.S. adults suffer from psoriatic arthritis: others may be at risk but not know it. Portland (OR): NPF Press Releases; May 15, 2002.URL:http://www.psoriasis.org/release2002.p sasurvey.htm.
3. Tassiulas I, Duncan SR, Centola M, et al. Clonal characteristics of T cell infiltrates in skin and synovium of patients with psoriatic arthritis. Hum Immunol. 1999;60:479-91.
4. Costello PJ, Winchester RJ, Curran SA, et al. Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions that appear antigen driven. J Immunol. 2001;166:28:78-86.
5. Jones G, Crotty M, Brooks P. Interventions for treating psoriatic arthritis (Cochrane Review). In: The Cochrane Library, Issue 3. Oxford: Update Software; 2001.
6. Black RL, O'Brien WM, Van Scott EJ, et al. Methotrexate therapy in psoriatic arthritis. JAMA. 1964;189:743-7.
7. Antoni C, Dechant C, Hanns-Martin Lorenz PD, et al. Open-label study of infliximab treatment for psoriatic arthritis: clinical and magnetic resonance imaging measurements of reduction of inflammation. Arthritis Care Res. 2002;47:506-12.
8. Mease PJ, Goffe BS, Metz J, et al. Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet. 2000;356:385-90.
9. Kraan MC, van Kuijk AW, Dinant HJ, et al. Alefacept treatment in psoriatic arthritis: reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis. Arthritis Rheum. 2002;46:2776-84.
10. Breedveld FC, Dayer JM. Leflunomide: mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis. 2000;59:841-9.
11. Smolen JS, Kalden JR, Scott DL, et al. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a doubleblind, randomized, multicentre trial. Lancet. 1999;353:259-66.
12. Strand V, Cohen S, SchiffM, et al. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch Intern Med. 1999;159:2542-50.
13. Clegg DO, Reda DJ, Mejias E, et al. comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis. Arthritis Rheum. 1996;39:2013-20.
14. Fredriksson T, Petterson U. severe psoriasisoral therapy with new retinoids. Acta Dermatologica. 1978;157:238-44.
15. SchiffMH. Strand V, Oed C, Loew-Friendrich I. Leflunomide: efficacy and safety in clinical trials for the treatment of rheumatoid arthritis. Drugs Today. 2000;36:383-94.
16. Spadaro A, Riccieri VA, Sili-scavalli, et al. Comparison of cyclosporine A and methotrexate in the treatment of psoriatic arthritis: a one year prospective study. Clin Exp Rheumatol. 1995;13:589-93.
17. Zachariae H, Zachariae E. Methotrexate: treatment of psoriatic arthritis. Acta Derm Venereol. 1987;67:270-3.