Anticancer effects of deproteinized asparagus polysaccharide on hepatocellular carcinoma in vitro and in vivo

Tumor Biology

Volumn 35, Issue 4, 2014, Pages 3517-3524

  Xiang, Jianfeng ^a   Xiang, Yanjie ^a   Lin, Shengming ^b   Xin, Dongwei ^b   Liu, Xiaoyu ^c   Weng, Lingling ^b   Chen, Tao ^c   Zhang, Minguang ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Shenzhen University School of Medicine   (China)

Author keywords

Apoptosis; Asparagus polysaccharide; Cell cycle arrest; Hepatocellular carcinoma

Indexed keywords

CASPASE 3; MITOMYCIN; POLYSACCHARIDE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASPARAGUS; CANCER CELL; CANCER INHIBITION; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LIVER CANCER; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ASPARAGUS PLANT; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LIVER NEOPLASMS; MITOMYCIN; POLYSACCHARIDES;

EID: 84898780583     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-1464-x     Document Type: Article

References (25)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63:11-30.
2. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet. 2003;362:1907-17.
3. Sangiovanni A, Del Ninno E, Fasani P, De Fazio C, Ronchi G, Romeo R, et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology. 2004;126:1005-14.
4. Llovet JM, Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol. 2008;48 Suppl 1:S20-37.
5. Tanaka T, Kohno H, Mori H. Chemoprevention of colon carcinogenesis by dietary non-nutritive compounds. Asian Pac J Cancer Prev. 2001;2:165-77.
6. Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet RA, Doody LA, et al. New agents for cancer chemoprevention. J Cell Biochem Suppl. 1996;26:1-28.
7. Corpet DE, Tache S. Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency. Nutr Cancer. 2002;43:1-21.
8. Shao Y, Chin CK, Ho CT, Ma W, Garrison SA, Huang MT. Anti-tumor activity of the crude saponins obtained from asparagus. Cancer Lett. 1996;104:31-6.
9. Shao Y, Poobrasert O, Kennelly EJ, Chin CK, Ho CT, Huang MT, et al. Steroidal saponins from Asparagus officinalis and their cytotoxic activity. Planta Med. 1997;63:258-62.
10. Huang X, Kong L. Steroidal saponins from roots of Asparagus officinalis. Steroids. 2006;71:171-6.
11. Makris DP, Rossiter JT. Domestic processing of onion bulbs (Allium cepa) and asparagus spears (Asparagus officinalis): effect on flavonol content and antioxidant status. J Agric Food Chem. 2001;49:3216-22.
12. Wang M, Tadmor Y, Wu QL, Chin CK, Garrison SA, Simon JE. Quantification of protodioscin and rutin in asparagus shoots by LC/MS and HPLC methods. J Agric Food Chem. 2003;51:6132-6.
13. Villanueva-Suarez MJ, Redondo-Cuenca A, Rodriguez-Sevilla MD, Heredia-Moreno A. Postharvest storage of white asparagus (Asparagus officinalis L.): changes in dietary fiber (nonstarch polysaccharides). J Agric Food Chem. 1999;47:3832-6.
14. Yamamori A, Onodera S, Kikuchi M, Shiomi N. Two novel oligosaccharides formed by 1f-fructosyltransferase purified from roots of asparagus (Asparagus officinalis L.). Biosci Biotechnol Biochem. 2002;66:1419-22.
15. Rodriguez R, Jaramillo S, Rodriguez G, Espejo JA, Guillen R, Fernandez-Bolanos J, et al. Antioxidant activity of ethanolic extracts from several asparagus cultivars. J Agric Food Chem. 2005;53:5212-7.
16. Jang DS, Cuendet M, Fong HH, Pezzuto JM, Kinghorn AD. Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2. J Agric Food Chem. 2004;52:2218-22.
17. Zhu X, Zhang W, Zhao J, Wang J, Qu W. Hypolipidaemic and hepatoprotective effects of ethanolic and aqueous extracts from Asparagus officinalis L. by-products in mice fed a high-fat diet. J Sci Food Agric. 2010;90:1129-35.
18. Wang H, Ng TB. Isolation of a novel deoxyribonuclease with antifungal activity from Asparagus officinalis seeds. Biochem Biophys Res Commun. 2001;289:120-4.
19. Liu W, Huang XF, Qi Q, Dai QS, Yang L, Nie FF, et al. Asparanin A induces G(2)/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Biochem Biophys Res Commun. 2009;381:700-5.
20. Bousserouel S, Le Grandois J, Gosse F, Werner D, Barth SW, Marchioni E, et al. Methanolic extract of white asparagus shoots activates trail apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model. Int J Oncol. 2013;43:394-404.
21. Wang J, Liu Y, Zhao J, Zhang W, Pang X. Saponins extracted from by-product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway. J Sci Food Agric. 2013;93(6):1492-8.
22. Wang J, Liu Y, Zhao J, Zhang W, Pang X. Saponins extracted from by-product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway. J Sci Food Agric. 2013;93:1492-8.
23. Kumari R, Sharma A, Ajay AK, Bhat MK. Mitomycin c induces bystander killing in homogeneous and heterogeneous hepatoma cellular models. Mol Cancer. 2009;8:87.
24. Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science. 2004;305:626-9.
25. Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssiere JL, Petit PX, et al. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med. 1995;181:1661-72.