Global Thrombosis Test (GTT) can detect major determinants of haemostasis including platelet reactivity, endogenous fibrinolytic and thrombin generating potential

Thrombosis Research

Volumn 133, Issue 5, 2014, Pages 919-926

  Yamamoto, J ^a   Inoue, N ^b   Otsui, K ^b   Ishii, H ^c   Gorog, D A ^d,e  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b KOBE ROSAI HOSPITAL   (Japan)

^c Ishii Hospital   (Japan)

^d UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Anticoagulant; Antithrombins; Fibrinolysis; Platelet aggregation; Platelet function; Thrombin

Indexed keywords

THROMBIN;

AGED; ANTAGONISTS AND INHIBITORS; BLOOD; BLOOD CLOTTING; BLOOD CLOTTING PARAMETERS; DRUG EFFECTS; FEMALE; FIBRINOLYSIS; HEMOSTASIS; HOSPITAL INFORMATION SYSTEM; HUMAN; MALE; METABOLISM; PHYSIOLOGY; PROCEDURES; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOSIS;

AGED; BLOOD COAGULATION; BLOOD PLATELETS; FEMALE; FIBRINOLYSIS; HEMOSTASIS; HUMANS; MALE; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; POINT-OF-CARE SYSTEMS; THROMBIN; THROMBOSIS;

EID: 84898770266     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.02.018     Document Type: Article

References (47)

1. A. Undas, K. Szuldrzynski, K.E. Brummel-Ziedins, W. Tracz, K. Zmudka, and K.G. Mann Systemic blood coagulation activation in acute coronary syndromes Blood 113 9 2009 2070 2078
2. M. Skeppholm, A. Kallner, K. Malmqvist, M. Blomback, and H. Wallen Is fibrin formation and thrombin generation increased during and after an acute coronary syndrome? Thromb Res 128 5 2011 483 489
3. M. Smid, AW. Dielis, M. Winkens, H.M. Spronk, R. van Oerle, and K. Hamulyák et al. Thrombin generation in patients with a first acute myocardial infarction J Thromb Haemost 9 2011 450 456
4. S.P. Jackson Arterial thrombosis- insidious, unpredictable and deadly Nat Med 17 2011 1423 1436
5. O. Rubin, J. Delobel, M. Prudent, N. Lion, K. Kohl, and E.I. Tucker et al. Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation Transfusion 53 8 2013 1744 1754
6. N. Amabile, P.E. Rautou, A. Tedgui, and C.M. Boulanger Microparticles: key protagonists in cardiovascular disorders Semin Thromb Hemost 36 8 2010 907 916
7. S. Montoro-García, E. Shantsila, L.D. Tapp, A. López-Cuenca, A.I. Romero, and D. Hernández-Romero et al. Small-size circulating microparticles in acute coronary syndromes: relevance to fibrinolytic status, reparative markers and outcomes Atherosclerosis 227 2 2013 313 322
8. D. Augustine, L.V. Ayers, E. Lima, L. Newton, A.J. Lewandowski, and E.F. Davis et al. Dynamic Release and Clearance of Circulating Microparticles During Cardiac Stress Circ Res 114 1 2013 109 113
9. P.K. Min, J.Y. Kim, K.H. Chung, B.K. Lee, M. Cho, and D.L. Lee et al. Local increase in microparticles from the aspirate of culprit coronary arteries in patients with ST-segment elevation myocardial infarction Atherosclerosis 227 2 2013 323 328
10. A. Undas, E. Stepien, A. Branicka, P. Wolkow, K. Zmudka, and W. Tracz Thrombin formation and platelet activation at the site of vascular injury in patients with coronary artery disease treated with clopidogrel combined with aspirin Kardiol Pol 67 6 2009 591 598
11. J.L. Mega, E. Braunwald, S.D. Wiviott, J.P. Bassand, D.L. Bhatt, and C. Bode et al. Rivaroxaban in Patients with a Recent Acute Coronary Syndrome N Engl J Med 366 2012 9 19
12. I.L. Holster, V.E. Valkhoff, E.J. Kuipers, and E.T. Tjwa New Oral Anticoagulants Increase Risk for Gastrointestinal Bleeding - A Systematic Review and Meta-Analysis Gastroenterology 145 1 2013 105 112 e15
13. R. Al Dieri, B. de Laat, and H.C. Hemker Thrombin generation: What have we learned? Blood Rev 26 5 2012 197 203
14. G. Campo, R. Pavasini, A. Pollina, L. Fileti, J. Marchesini, and M. Tebaldi et al. Thrombin generation assay: a new tool to predict and optimize clinical outcome in cardiovascular patients? Blood Coagul Fibrinolysis 23 8 2012 680 687
15. W. Wegert, J. Graff, D. Kaiser, H.K. Breddin, U. Klinkhardt, and S. Harder Int J Clin Pharmacol Ther 40 4 2002 135 141
16. V. Peyrou, J.C. Lormeau, J.P. Hérault, C. Gaich, A.M. Pfliegger, and J.M. Herbert Contribution of erythrocytes to thrombin generation in whole blood Thromb Haemost 81 3 1999 400 406
17. M. Ninivaggi, R. Apitz-Castro, Y. Dargaud, B. de Laat, H.C. Hemker, and T. Lindhout Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay Clin Chem 58 8 2012 1252 1259
18. N. Tamura, I. Kitajima, Y. Kawamura, E. Toda, Y. Eguchi, and H. Ishida et al. Important regulatory role of activated platelet-derived procoagulant activity in the propagation of thrombi formed under arterial blood flow conditions Circ J 73 3 2009 540 548
19. S. Sharma, K. Farrington, R. Kozarski, C. Christopoulos, M. Niespialowska-Steuden, and D. Moffat et al. Impaired thrombolysis: a novel cardiovascular risk factor in end-stage renal disease Eur Heart J 34 5 2013 354 363
20. D.A. Gorog, and V. Fuster Platelet function tests in clinical cardiology: unfulfilled expectations J Am Coll Cardiol 61 21 2013 2115 2129
21. S.J. Davidson, J.F. Burman, S.M. Philips, S.J. Onis, A.A. Kelleher, and A.C. De Souza et al. Correlation between thrombin potential and bleeding after cardiac surgery in adults Blood Coagul Fibrinolysis 14 2 2003 175 179
22. L. Yang, M. Oakley, C. Evans, J. Hall, and P. Collins Thrombin generation predicts bleeding following cardiopulmonary bypass surgery Eur J Anaesthesiol 27 47 2010 103
23. M. Coakley, J.E. Hall, C. Evans, E. Duff, V. Billing, and L. Yang et al. Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding J Thromb Haemost 9 2 2011 282 292
24. F.I. Aullakhanov, A.V. Pohilko, E.I. Sinauridze, and R.I. Volkova Calcium threshold in human clotting kinetics Thromb Res 75 4 1994 383 394
25. K.G. Mann, M.F. Whelihan, S. Butenas, and T. Orfeo Citrate anticoagulation and the dynamics of thrombin generation J Thromb Haemost 5 10 2007 2055 2061
26. Z.M. Ruggeri, J.N. Orje, R. Habermann, A.B. Federici, and A.J. Reininger Activation-independent platelet adhesion and aggregation under elevated shear stress Blood 108 2006 1903 1910
27. A.J. Reininger, H.F. Heijnen, H. Schumann, H.M. Specht, W. Schramm, and Z.M. Ruggeri Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress Blood 107 9 2006 3537 3545
28. D. Alexopoulos, A. Galati, I. Xanthopoulou, E. Mavronasiou, G. Kassimis, and K.C. Theodoropoulos et al. Ticagrelor versus prasugrel in acute coronary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: a pharmacodynamic study J Am Coll Cardiol 60 3 Jul 17 2012 193 199
29. L. Bonello, M. Pansieri, J. Mancini, R. Bonello, L. Maillard, and P. Barnay et al. High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after percutaneous coronary intervention in acute coronary syndromes J Am Coll Cardiol 58 2011 467 473
30. J. Silvain, J. Abtan, G. Cayla, S.A. O'Connor, O. Barthélé my, and J.B. Vignalou et al. Switching acute coronary syndrome patients from prasugrel to clopidogrel JACC Cardiovasc Interv 6 2 2013 158 165
31. T.W. Stief Thrombin generation by hemolysis Blood Coagul Fibrinolysis 18 1 2007 61 66
32. O. Rubin, J. Delobel, M. Prudent, N. Lion, K. Kohl, and E.I. Tucker et al. Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation Transfusion 5398 2013 1744 1754
33. M.F. Whelihan, and K.G. Mann The role of the red cell membrane in thrombin generation Thromb Res 131 5 2013 377 382
34. R. Loeffen, M.C. Kleinegris, S.T. Loubele, P.H. Pluijmen, D. Fens, and R. van Oerle et al. Preanalytic variables of thrombin generation: towards a standard procedure and validation of the method J Thromb Haemost 10 12 2012 2544 2554
35. G.T. Gerotziafas, F. Depasse, J. Busson, L. Leflem, I. Elalamy, and M.M. Samama Towards a standardization of thrombin generation assessment: the influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay Thromb J 3 2005 16
36. G.T. Gerotziafas, P. Van Dreden, M. Chaari, V. Galea, A. Khaterchi, and F. Lionnet et al. The acceleration of the propagation phase of thrombin generation in patients with steady-state sickle cell disease is associated with circulating erythrocyte-derived microparticles Thromb Haemost 107 6 2012 1044 1052
37. M.F. Whelihan, V. Zachary, T. Orfeo, and K.G. Mann Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation Blood 120 18 2012 3837 3845
38. N. Muyesai, S. Amuti, and G. Li Plasma levels of red blood cell derived microparticles in Xinjiang Uiygur patients with acute coronary syndrome. ASSA13-01-4 Heart 99 Suppl. 1 2013 A1 A2
39. P.E. Van Der Meijden, M. Van Schilfgaarde, R. Van Oerle, T. Renné, H. ten Cate, and H.M. Spronk Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa J Thromb Haemost 10 7 2012 1355 1362
40. W. Jy, M.E. Johansen, C. Bidot Jr., L. Horstman, and Y.S. Ahn Red cell-derived microparticles (RMP) as haemostatic agent Thromb Haemost 110 4 2013 Sep 12 751 760
41. S.S. Choi, Z. Sergie, and R. Mehran Impact of in-hospital major bleeding on outcomes in acute coronary syndromes Curr Opin Cardiol 27 6 2012 669 674
42. K. McConeghy, A. Bress, and C. Wing Reports of bleeding-related fatalities with dabigatran and warfarin: an analysis using the Food and Drug Administration adverse events reporting system J Am Coll Cardiol 61 10 S 2013 [American College of Cardiology (ACC) 2013 Scientific Sessions. Abstract 914-8.]
43. J.P. Bassand Current antithrombotic agents for acute coronary syndromes: Focus on bleeding risk Int J Cardiol 163 1 2013 5 18
44. S. Bloemen, H.C. Hemker, and Dieri R. Al Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation Haematologica 98 4 2013 549 554
45. M. Kawabata, Y. Yokoyama, T. Sasano, H. Hachiya, Y. Tanaka, and A. Yagishita et al. Bleeding events and activated partial thromboplastin time with dabigatran in clinical practice J Cardiol 62 2 2013 121 126
46. G. Ndrepepa, T. Schuster, M. Hadamitzky, R.A. Byrne, J. Mehilli, and F.J. Neumann et al. Validation of the Bleeding Academic Research Consortium definition of bleeding in patients with coronary artery disease undergoing percutaneous coronary intervention Circulation 125 11 2012 1424 1431
47. J. Donzé, N. Rodondi, G. Waeber, P. Monney, J. Cornuz, and D. Aujesky Scores to predict major bleeding risk during oral anticoagulation therapy: a prospective validation study Am J Med 125 11 2012 1095 1102