Multidrug-resistant gram-negative bloodstream infections among residents of long-term care facilities

Infection Control and Hospital Epidemiology

Volumn 35, Issue 5, 2014, Pages 519-526

  Venkatachalam, Indumathi ^a   Yang, Hsu Li ^a   Fisher, Dale ^a   Lye, David C ^b   Lin, Ling Moi ^c   Tambyah, Paul ^a   Perl, Trish M ^d  

^a NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^b TAN TOCK SENG HOSPITAL   (Singapore)

^c SINGAPORE GENERAL HOSPITAL   (Singapore)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METALLO BETA LACTAMASE; ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC SENSITIVITY; ARTICLE; BLOODSTREAM INFECTION; CHARLSON COMORBIDITY INDEX; CONTROLLED STUDY; DISEASE ASSOCIATION; DISK DIFFUSION; FEMALE; FOLLOW UP; GEOGRAPHIC DISTRIBUTION; GRAM NEGATIVE INFECTION; HEALTH CARE MANAGEMENT; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANCE; OUTCOME ASSESSMENT; PATIENT IDENTIFICATION; PREVALENCE; RESIDENTIAL CARE; RISK ASSESSMENT; VERY ELDERLY; CROSS INFECTION; EPIDEMIOLOGY; GRAM-NEGATIVE BACTERIAL INFECTIONS; MICROBIOLOGY; MIDDLE AGED; NURSING HOME; RISK FACTOR; SEPSIS; SINGAPORE; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; LONG-TERM CARE; MALE; MIDDLE AGED; NURSING HOMES; PREVALENCE; RISK FACTORS; SEPSIS; SINGAPORE; YOUNG ADULT;

EID: 84898768991     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/675823     Document Type: Article

References (33)

1. Hsu LY, Tan T, Tam V et al. Surveillance and correlation of antibiotic prescription and resistance of gram-negative bacteria in Singaporean hospitals. Antimicrob Agents Chemother 2010; 54(3):1173-1178.
2. van Duijn P, Dautzenberg M, Oostdijk E. Recent trends in antibiotic resistance in European ICUs. Curr Opin Crit Care 2011; 17(6):658-665.
3. Boucher H, Talbot G, Bradley J, et al. Bad bugs, no drugs: no ESKAPE! an update from the Infectious Diseases Society of America. Clin Infect Dis 2009;48(1):1-12.
4. Lo W, Lin W, Chiueh T et al. Changing trends in antimicrobial resistance of major bacterial pathogens, 1985-2005: a study from a medical center in northern Taiwan. J Microbiol Immunol Infect 2011;44(2):131-138.
5. Klevens RM, Edwards JR, Gaynes RP. The impact of antimicrobial-resistant health care-associated infections on mortality in the United States. Clin Infect Dis 2008;47:927-930.
6. Walsh TR, Weeks J, Livermore DM, Toleman MA. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis 2011;11:355-362.
7. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009;9:228-236.
8. Hsu LY, Tan T, Jureen R, et al. Antimicrobial drug resistance in hospitals. Emerg Infect Dis 2007;13(12):2-5.
9. Kiratisin P, Chongthaleong A, Tan TY, et al. Comparative in vitro activity of carbapenems against major gram-negative pathogens: results of Asia-Pacific surveillance from the COMPACT II study. Int J Antimicrob Agents 2012;39(4):311-316.
10. O'Fallon E, Schreiber R, Kandel R, D'Agata EMC. Multidrugresistant gram-negative bacteria at a long-term care facility: assessment of residents, healthcare workers, and inanimate surfaces. Infect Control Hosp Epidemiol 2009;30(12):1172-1179.
11. Won SY, Munoz-Price LS, Lolans K, Hota B, Weinstein R, Hayden M. Emergence and rapid regional spread of Klebsiella pneumoniae carbapenemases-producing Enterobacteriaceae. Clin Infect Dis 2011;53(6):532-540.
12. O'Fallon E, Schreiber R, Kandel R, D'Agata EMC. Multidrugresistant gram-negative bacteria at a long-term care facility: assessment of residents, healthcare workers, and inanimate surfaces. Infect Control Hosp Epidemiol 2009;30(12):1172-1179.
13. Prabaker K, Lin M, McNally M, et al. Transfer from high-acuity long-term care facilities is associated with carriage of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae: a multihospital study. Infect Control Hosp Epidemiol 2012;33(12): 1193-1199.
14. Stuart R, Kotsana D, Webb B, et al. Prevalence of antimicrobialresistant organisms in residential aged care facilities. Med J Aust 2011;195(9):530-533.
15. March A, Aschbacher R, Dhanji H, et al. Colonization of residents and staff of a long-term-care facility and adjacent acutecare hospital geriatric unit by multiresistant bacteria. Clin Microbiol Infect 2010;16(7):934-944.
16. World population ageing 2009. United Nations Department of Economic and Social Affairs Population Division. http://www.un.org/en/development/desa/publications/world-populationageing-2009.html. Accessed on April 2, 2013.
17. Lye D, Earnest A, Ling M, et al. The impact of multidrug resistance in healthcare-associated and nosocomial gram-negative bacteremia on mortality and length of stay: cohort study. Clin Microbiol Infect 2012;18(5):502-508.
18. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference of Chest Physcians/Society of Critical Care Medicine. Chest 1992;101: 1644-1655.
19. Friedman ND, Kaye KS, Stout JE, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002;137:791-797.
20. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309-332.
21. Kallen A, Hildron A, Patel J, Srinivasan A. Multidrug resistance among gram negative pathogens that caused heathcare-associated infections reported to the National Healthcare Safety Network, 2006-2008. Infect Control Hosp Epidemiol 2010;31:528-531.
22. Clinical Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Disk Susceptibility Tests. Wayne, PA: CLSI, 2009. CLSI document M02-A10.
23. Gilbert DN, Moellering RC, Eliopoulos GM, et al. The Sanford Guide to Antimicrobial Therapy 2008. 38th ed. Sperryville, VA: Antimicrobial Therapy, 2008.
24. Charlson M, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-383.
25. Centers for Disease Control and Prevention. Guidance for control of infections with carbapenem-resistant or carbapenemaseproducing Enterobacteriaceae in acute care facilities. MMWR Morb Mortal Wkly Rep 2009;58:256-260.
26. Grundman H, Livermore DM, Giske CG, et al. Carbapenemnonsusceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill 2010;15:pii:19711.
27. Akova M, Daikos GL, Tzouvelekis L, Carmeli Y. Interventional strategies and current clinical experience with carbapenemaseproducing gram-negative bacteria. Clin Microbiol Infect 2012;18: 439-448.
28. Pop-Vicas A, Tacconelli E, Gravenstein S, Lu B, D'Agata EM. Influx of multidrug-resistant, gram-negative bacteria in the hospital setting and the role of elderly patients with bacterial bloodstream infection. Infect Control Hosp Epidemiol 2009;30:325-331.
29. Carmeli Y, Troillet N, Karchmer AW, Samore MH. Health and economic outcomes of antibiotic resistance in Pseudomonas aeruginosa. Arch Intern Med 1999;159:1127-1132.
30. de Kraker MEA, Davey PG, Grundmann H. Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe. PLOS MED 2011;8(10):e1001104.
31. Sunenshine FH, Wright MO, Maragakis LL, et al. Multidrugresistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis 2007;13(1):97-103.
32. Choi JP, Cho EH, Lee SJ, Lee ST, Koo MS, Song YG. Influx of multidrug resistant, gram-negative bacteria (MDRGNB) in a public hospital among elderly from long-term care facilities: a single-center pilot study. Arch Gerontol Geriatr 2012;54(2):e19-e22.
33. Gudiol C, Tubau F, Calatayud L, et al. Bacteremia due to multidrug-resistant bram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes. J Antimicrob Chemother 2011;66:657-663.