The impact of multidrug resistance in healthcare-associated and nosocomial Gram-negative bacteraemia on mortality and length of stay: Cohort study

Clinical Microbiology and Infection

Volumn 18, Issue 5, 2012, Pages 502-508

  Lye, D C ^a   Earnest, A ^a,b   Ling, M L ^c   Lee, T E ^d   Yong, H C ^d   Fisher, D A ^d   Krishnan, P ^a   Hsu, L Y ^d  

^a TAN TOCK SENG HOSPITAL   (Singapore)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

^c SINGAPORE GENERAL HOSPITAL   (Singapore)

^d NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

Author keywords

Antimicrobial drug resistance; Cohort study; Gram negative bacteraemia; Length of stay; Mortality

Indexed keywords

ANTIBIOTIC AGENT;

ADULT; AGED; ANTIBIOTIC THERAPY; APACHE; ARTICLE; COMORBIDITY; CONCURRENT INFECTION; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; GRAM NEGATIVE SEPSIS; HOSPITAL INFECTION; HUMAN; INTENSIVE CARE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIDRUG RESISTANT NOSOCOMIAL GRAM NEGATIVE BACTEREMIA; OBSERVATIONAL STUDY; PNEUMONIA; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SEX DIFFERENCE; SINGAPORE; SURGICAL WARD; SURVIVOR; URINARY TRACT INFECTION;

NEGIBACTERIA;

EID: 84859911288     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2011.03606.x     Document Type: Article

References (27)

1. Boucher HW, Talbot GH, Bradley JS et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009; 48: 1-12.
2. Hsu LY, Tan TY, Tam VH et al. Surveillance and correlation of antibiotic prescription and resistance of Gram-negative bacteria in Singaporean hospitals. Antimicrob Agents Chemother 2010; 54: 1173-1178.
3. Blot S, Vandewoude K, De Bacquer D et al. Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization. Clin Infect Dis 2002; 34: 1600-1606.
4. Giske CG, Monnet DL, Cars O et al. Clinical and economic impact of common multidrug-resistant gram-negative bacilli. Antimicrob Agents Chemother 2008; 52: 813-821.
5. Shorr AF. Review of studies of the impact on Gram-negative bacterial resistance on outcomes in the intensive care unit. Crit Care Med 2009; 37: 1463-1469.
6. Slama TG. Gram-negative antibiotic resistance: there is a price to pay. Crit Care 2008; 12 (suppl 4): S4.
7. Mauldin PD, Salgado CD, Hansen IS et al. Attributable hospital cost and length of stay associated with health care-associated infections caused by antibiotic-resistant gram-negative bacteria. Antimicrob Agents Chemother 2010; 54: 109-115.
8. Paul M, Shani V, Muchtar E et al. Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis. Antimicrob Agents Chemother 2010; 54: 4851-4863.
9. Tam VH, Rogers CA, Chang KT et al. Impact of multidrug-resistant Pseudomonas aeruginosa bacteremia on patient outcomes. Antimicrob Agents Chemother 2010; 54: 3717-3722.
10. Blot S, Depuydt SP, Vandewoude K et al. Measuring the impact of multidrug resistance in nosocomial infection. Curr Opin Infect Dis 2007; 20: 391-396.
11. Lambert ML, Suetens C, Savey A et al. Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study. Lancet Infect Dis 2011; 11: 30-38.
12. Graves N, Harbarth S, Beyersmann J et al. Estimating the cost of health care-associated infections: mind your p's and q's. Clin Infect Dis 2010; 50: 1017-1021.
13. Bone RC, Balk RA, Cerra FB et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-1655.
14. Friedman ND, Kaye KS, Stout JE et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002; 137: 791-797.
15. Kallen AJ, Hidron AI, Patel J et al. Multidrug resistance among Gram-negative pathogens that caused healthcare-associated infections reported to the National Healthcare Safety Network, 2006-2008. Infect Control Hosp Epidemiol 2010; 31: 528-531.
16. Falagas ME, Koletsi PK, Bliziotis IA. The diversity of definitions of multidrug-resistant (MDR) and pandrug-resistant (PDR) Acinetobacter baumannii and Pseudomonas aeruginosa. J Med Microbiol 2006; 55: 1619-1629.
17. Magiorakos AP, Srinivasan A, Carey RB et al. Multidrug resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2011; [In press].
18. Clinical Laboratory Standards Institute. Performance standards for antimicrobial disk susceptibility tests. M02-A10, Vol 29(1). Wayne, Pennsylvania, USA: CLSI, 2009.
19. Knaus WA, Draper EA, Wagner DP et al. APACHE II: a severity disease classification system. Crit Care Med 1985; 13: 818-829.
20. Charlson ME, Pompei P, Ales K et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-383.
21. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008; 36: 309-332.
22. Gilbert DN, Moellering RC, Eliopoulos GM et al. The Sanford Guide to Antimicrobial Therapy 2008, 38th edn. Sperryville, VA, USA: Antimicrobial Therapy, Inc, 2008.
23. Lin MY, Weinstein RA, Hota B. Delay of active antimicrobial therapy and mortality among patients with bacteremia: impact of severe neutropenia. Antimicrob Agents Chemother 2008; 52: 3188-3194.
24. Schwaber MJ, Carmeli Y. Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis. J Antimicrob Chemother 2007; 60: 913-920.
25. Andersson DI, Hughes D. Antibiotic resistance and its cost: is it possible to reverse resistance? Nat Rev Microbiol 2010; 8: 260-271.
26. Adrie C, Azoulay E, Francais A et al. Influence of gender on the outcome of severe sepsis: a reappraisal. Chest 2007; 132: 1786-1793.
27. Wafaisade A, Lefering R, Bouillon B et al. Epidemiology and risk factors of sepsis after multiple trauma: an analysis of 29, 829 patients from the Trauma Registry of the German Trauma Society. Crit Care Med 2011; 39: 621-628.