Aberrant presentation of HPA-reactive carbohydrates implies selectin-independent metastasis formation in human prostate cancer

Clinical Cancer Research

Volumn 20, Issue 7, 2014, Pages 1791-1802

  Lange, Tobias ^a   Kupfernagel, Mareike ^a   Wicklein, Daniel ^a   Gebauer, Florian ^a   Maar, Hanna ^a   Brügge, Kathrin ^a   Müller, Imke ^a   Simon, Ronald ^a   Schlomm, Thorsten ^a   Sauter, Guido ^a   Schumacher, Udo ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE DERIVATIVE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOSYLTRANSFERASE; HELIX POMATIA AGGLUTININ REACTIVE CARBOHYDRATE; SELECTIN; UNCLASSIFIED DRUG; CARBOHYDRATE; HELIX LECTIN; LECTIN; LIGAND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER PROGNOSIS; CARCINOGENESIS; CELL INTERACTION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GLYCOSYLATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG METASTASIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; SHEAR STRESS; TUMOR CELL; TUMOR XENOGRAFT; ANIMAL; CHEMISTRY; DISEASE COURSE; DRUG SCREENING; GENETICS; LYMPH NODE METASTASIS; METABOLISM; PATHOLOGY; PROSTATE TUMOR;

ANIMALS; BINDING SITES; CARBOHYDRATES; DISEASE PROGRESSION; E-SELECTIN; HUMANS; LECTINS; LIGANDS; LYMPHATIC METASTASIS; MALE; MICE; PROSTATIC NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898714492     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-2308     Document Type: Article

References (47)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
2. Schumacher U, Adam E. Lectin histochemical HPA-binding pattern of human breast and colon cancers is associated with metastases formation in severe combined immunodeficient mice. Histochem J 1997;29:677-84. (Pubitemid 27489870)
3. Reis CA, Osorio H, Silva L, Gomes C, David L. Alterations in glycosylation as biomarkers for cancer detection. J Clin Pathol 2010;63:322-9.
4. Varki A, Kannagi R, Toole BP. Glycosylation Changes in Cancer. In: Varki A, Cummings RD, Esko JD, et al. editors. Essentials of Glycobiology. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2009.
5. Schultz MJ, Swindall AF, Bellis SL. Regulation of the metastatic cell phenotype by sialylated glycans. Cancer Metastasis Rev 2012;31:501-18.
6. Mitchell BS, Schumacher U. The use of the lectin Helix pomatia agglutinin (HPA) as a prognostic indicator and as a tool in cancer research. Histol Histopathol 1999;14:217-26. (Pubitemid 29049369)
7. Brooks SA. The involvement of Helix pomatia lectin (HPA) binding N-acetylgalactosamine glycans in cancer progression. Histol Histopathol 2000;15:143-58. (Pubitemid 30044299)
8. Laack E, Nikbakht H, Peters A, Kugler C, Jasiewicz Y, Edler L, et al. Lectin histochemistry of resected adenocarcinoma of the lung: helix pomatia agglutinin binding is an independent prognostic factor. Am J Pathol 2002;160:1001-8. (Pubitemid 34224588)
9. Kakeji Y, Tsujitani S, Mori M, Maehara Y, Sugimachi K. Helix pomatia agglutinin binding activity is a predictor of survival time for patients with gastric carcinoma. Cancer 1991;68:2438-42.
10. Thies A, Moll I, Berger J, Schumacher U. Lectin binding to cutaneous malignant melanoma: HPA is associated with metastasis formation. Br J Cancer 2001;84:819-23. (Pubitemid 32275657)
11. Rambaruth ND, Greenwell P, Dwek MV. The lectin Helix pomatia agglutinin recognizes O-GlcNAc containing glycoproteins in human breast cancer. Glycobiology 2012;22:839-48.
12. Shimodaira K, Nakayama J, Nakamura N, Hasebe O, Katsuyama T, Fukuda M. Carcinoma-associated expression of core 2 beta-1,6-N- acetylglucosaminyltransferase gene in human colorectal cancer: role of O-glycans in tumor progression. Cancer Res 1997;57:5201-6. (Pubitemid 27516348)
13. Stübke K, Wicklein D, Herich L, Schumacher U, Nehmann N. Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer. Cancer Lett 2012;321:89-99.
14. Köhler S, Ullrich S, Richter U, Schumacher U. E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung. Br J Cancer 2010;102:602-9.
15. Gebauer F, Wicklein D, Stubke K, Nehmann N, Schmidt A, Salamon J, et al. Selectin binding is essential for peritoneal carcinomatosis in a xenograft model of human pancreatic adenocarcinoma in pfp-/rag2-mice. Gut 2013;62:741-50.
16. Wicklein D, Schmidt A, Labitzky V, Ullrich S, Valent P, Schumacher U. E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model. PLoS One 2013;8:e70139.
17. St Hill CA. Interactions between endothelial selectins and cancer cells regulate metastasis. Front Biosci 2011;16:3233-51.
18. Labelle M, Hynes RO. The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov 2012;2:1091-9.
19. Julien S, Ivetic A, Grigoriadis A, QiZe D, Burford B, Sproviero D, et al. Selectin ligand sialyl-Lewis x antigen drives metastasis of hormonedependent breast cancers. Cancer Res 2011;71:7683-93.
20. Martin-Satue M, Marrugat R, Cancelas JA, Blanco J. Enhanced expression of alpha(1,3)-fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells. Cancer Res 1998;58:1544-50. (Pubitemid 28193622)
21. Valentiner U, Hall DM, Brooks SA, Schumacher U. HPA binding and metastasis formation of human breast cancer cell lines transplanted into severe combined immunodeficient (scid) mice. Cancer Lett 2005;219:233-42. (Pubitemid 40269488)
22. Lange T, Ullrich S, Muller I, Nentwich MF, Stubke K, Feldhaus S, et al. Human prostate cancer in a clinically relevant xenograft mouse model: identification of beta(1,6)-branched oligosaccharides as a marker of tumor progression. Clin Cancer Res 2012;18:1364-73.
23. Kalinina T, Gungor C, Thieltges S, Moller-Krull M, Penas EM, Wicklein D, et al. Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung. BMC Cancer 2010;10:295.
24. Korenchuk S, Lehr JE, L MC, Lee YG, Whitney S, Vessella R, et al. VCaP, a cell-based model system of human prostate cancer. In Vivo 2001;15:163-8.
25. Richter U, Schroder C, Wicklein D, Lange T, Geleff S, Dippel V, et al. Adhesion of small cell lung cancer cells to E- and P-selectin under physiological flow conditions: implications for metastasis formation. Histochem Cell Biol 2011;135:499-512.
26. Mierke CT. Cancer cells regulate biomechanical properties of human microvascular endothelial cells. J Biol Chem 2011;286:40025-37.
27. Ahmed MN, Zhang Y, Codipilly C, Zaghloul N, Patel D, Wolin M, et al. Extracellular superoxide dismutase overexpression can reverse the course of hypoxia-induced pulmonary hypertension. Mol Med 2012;18:38-46.
28. Jojovic M, Schumacher U. Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice. Cancer Lett 2000;152:151-6. (Pubitemid 30201496)
29. Nehmann N, Wicklein D, Schumacher U, Muller R. Comparison of two techniques for the screening of human tumor cells in mouse blood: quantitative real-time polymerase chain reaction (qRT-PCR) versus laser scanning cytometry (LSC). Acta Histochem 2010;112:489-96.
30. El Gammal AT, Bruchmann M, Zustin J, Isbarn H, Hellwinkel OJ, Kollermann J, et al. Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer. Clin Cancer Res 2010;16:56-64.
31. Fleischmann A, Schlomm T, Huland H, Kollermann J, Simon P, Mirlacher M, et al. Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients. Clin Cancer Res 2008;14:7838-42.
32. Minner S, Enodien M, Sirma H, Luebke AM, Krohn A, Mayer PS, et al. ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy. Clin Cancer Res 2011;17:5878-88.
33. Bubendorf L, Kononen J, Koivisto P, Schraml P, Moch H, Gasser TC, et al. Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays. Cancer Res 1999;59:803-6. (Pubitemid 29086730)
34. Gao Y, Chachadi VB, Cheng PW, Brockhausen I. Glycosylation potential of human prostate cancer cell lines. Glycoconj J 2012;29:525-37.
35. Li Q, Anver MR, Butcher DO, Gildersleeve JC. Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines. Mol Cancer Ther 2009;8:971-9.
36. Premaratne P, Welen K, Damber JE, Hansson GC, Backstrom M. O-glycosylation of MUC1 mucin in prostate cancer and the effects of its expression on tumor growth in a prostate cancer xenograft model. Tumour Biol 2011;32:203-13.
37. Kirschenbaum A, Itzkowitz SH, Wang JP, Yao S, Eliashvili M, Levine AC. MUC1 expression in prostate carcinoma: correlation with grade and stage. Mol Urol 1999;3:163-8.
38. Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, et al. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion. Cancer Lett 2009;283:29-35.
39. Pontes-Junior J, Reis ST, de Oliveira LC, Sant'anna AC, Dall'oglio MF, Antunes AA, et al. Association between integrin expression and prognosis in localized prostate cancer. Prostate 2010;70:1189-95.
40. Yoshioka T, Otero J, Chen Y, Kim YM, Koutcher JA, Satagopan J, et al. beta4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest 2013;123:682-99.
41. Barthel SR, Hays DL, Yazawa EM, Opperman M, Walley KC, Nimrichter L, et al. Definition of molecular determinants of prostate cancer cell bone extravasation. Cancer Res 2013;73:942-52.
42. Barthel SR, Wiese GK, Cho J, Opperman MJ, Hays DL, Siddiqui J, et al. Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc Natl Acad Sci U S A 2009;106:19491-6.
43. Batson OV. The function of the vertebral veins and their role in the spread of metastases. Ann Surg 1940;112:138-49.
44. Bubendorf L, Schopfer A, Wagner U, Sauter G, Moch H, Willi N, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol 2000;31:578-83. (Pubitemid 30323983)
45. Geldof AA. Models for cancer skeletal metastasis: a reappraisal of Batson's plexus. Anticancer Res 1997;17:1535-9. (Pubitemid 27257642)
46. Springer GF. Tn epitope (N-acetyl-D-galactosamine alpha-O-serine/ threonine) density in primary breast carcinoma: a functional predictor of aggressiveness. Mol Immunol 1989;26:1-5. (Pubitemid 19024635)
47. Sheikh S, Rainger GE, Gale Z, Rahman M, Nash GB. Exposure to fluid shear stressmodulates theability ofendothelialcells to recruitneutrophils in response to tumor necrosis factor-alpha: a basis for local variations in vascular sensitivity to inflammation. Blood 2003;102:2828-34. (Pubitemid 37248853)