Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus

Journal of International Medical Research

Volumn 42, Issue 2, 2014, Pages 581-588

  Sefil, Fatih ^a   Ulutas, Kemal Turker ^a   Dokuyucu, Recep ^a   Sumbul, Ahmet Taner ^a   Yengil, Erhan ^a   Yagiz, Abdullah Erman ^a   Yula, Erkan ^a   Ustun, Ihsan ^a   Gokce, Cumali ^a  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

Author keywords

diabetes mellitus; neutrophil lymphocyte ratio

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C;

ADULT; ARTICLE; BASOPHIL; BLOOD GLUCOSE MONITORING; CLINICAL ARTICLE; CONTROLLED STUDY; EOSINOPHIL COUNT; FEMALE; GLUCOSE BLOOD LEVEL; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; HUMAN; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MONOCYTE; NEUTROPHIL COUNT; NEUTROPHIL LYMPHOCYTE RATIO; NON INSULIN DEPENDENT DIABETES MELLITUS; RETROSPECTIVE STUDY;

DIABETES MELLITUS; GLYCOSYLATED HAEMOGLOBIN (HBA1C); NEUTROPHIL LYMPHOCYTE RATIO;

BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; LEUKOCYTOSIS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MIDDLE AGED; NEUTROPHILS; RETROSPECTIVE STUDIES;

EID: 84898687129     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060513516944     Document Type: Article

References (31)

1. Lewis MR,Tracy RP.The role of the immune system in the insulin resistance syndrome.Curr Diab Rep. 2002;2:96-99.
2. Gündogan K,Bayram F,Capak M, et al.Prevalence of metabolic syndrome in the Mediterranean region of Turkey: evaluation of hypertension, diabetes mellitus, obesity, and dyslipidemia.Metab Syndr Relat Disord. 2009;7:427-434.
3. Ohshita K,Yamane K,Hanafusa M, et al.Elevated white blood cell count in subjects with impaired glucose tolerance.Diabetes Care. 2004;27:491-496.
4. Tsai JC,Sheu SH,Chiu HC, et al.Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitus.Diabetes Metab Res Rev. 2007;23:111-118.
5. de Rooij SR,Nijpels G,Nilsson PM, et al.Low-grade chronic inflammation in the relationship between insulin sensitivity and cardiovascular disease (RISC) population: associations with insulin resistance and cardiometabolic risk profile.Diabetes Care. 2009;32:1295-1301.
6. Fernández-Real JM,Ricart W.Insulin resistance and chronic cardiovascular inflammatory syndrome.Endocr Rev. 2003;24:278-301.
7. Coller BS.Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene?.Arterioscler Thromb Vasc Biol. 2005;25:658-670.
8. Hansson GK.Inflammation, atherosclerosis, and coronary artery disease.N Engl J Med. 2005;352:1685-1695.
9. Tong PC,Lee KF,So WY, et al.White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes.Diabetes Care. 2004;27:216-222.
10. Imtiaz F,Shafique K,Mirza SS, et al.Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population.Int Arch Med. 2012;5:2-2.
11. Buyukkaya E,Karakas MF,Karakas E, et al.Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome.Clin Appl Thromb Hemost. 2014;20:159-163.
12. Alberti KG,Zimmet PZ.Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.Diabet Med. 1998;15:539-553.
13. Diagnosis and classification of diabetes mellitus.Diabetes Care. 2013;36:S67-S74.
14. Vozarova B,Weyer C,Lindsay RS, et al.High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes.Diabetes. 2002;51:455-461.
15. 1c levels and risk of cardiovascular adverse outcomes and all-cause mortality in overweight and obese cardiovascular high-risk women and men with type 2 diabetes.Diabetologia. 2012;55:2348-2355.
16. Yousefzadeh P,Wang X.The effects of dipeptidyl peptidase-4 inhibitors on cardiovascular disease risks in type 2 diabetes mellitus.J Diabetes Res. 2013;2013:459-821.
17. Stulc T,Ceska R,Marinov I, et al.The effect of simvastatin and fenofibrate on the expression of leukocyte adhesion molecules and lipopolysaccharide receptor CD14 in type 2 diabetes mellitus.Neuro Endocrinol Lett. 2012;33:73-77.
18. Eckel RH,Wassef M,Chait A, et al.Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes.Circulation. 2002;105:e138-e143.
19. Saito Y,Takahashi I,Iwane K, et al.The influence of blood glucose on neutrophil function in individuals without diabetes.Luminescence. 2013;28:569-573.
20. Danaei G,Lawes CM,Vander Hoorn S, et al.Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: comparative risk assessment.Lancet. 2006;368:1651-1659.
21. Duffy BK,Gurm HS,Rajagopal V, et al.Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention.Am J Cardiol. 2006;97:993-996.
22. Sen N,Afsar B,Ozcan F, et al.The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction undergoing primary coronary intervention.Atherosclerosis. 2013;228:203-210.
23. Khodabandehlou T,Zhao H,Vimeux M, et al.Haemorheological consequences of hyperglycaemic spike in healthy volunteers and insulin-dependent diabetics.Clin Hemorheol Microcirc. 1998;19:105-114.
24. Suzuki T,Futami-Suda S,Igari Y, et al.Low-molecular-weight lipoprotein (a) and low relative lymphocyte concentration are significant and independent risk factors for coronary heart disease in patients with type 2 diabetes mellitus: Lp(a) phenotype, lymphocyte, and coronary heart disease.Lipids Health Dis. 2013;12:31-31.
25. Chang FY,Shaio MF.Decreased cell-mediated immunity in patients with non-insulin-dependent diabetes mellitus.Diabetes Res Clin Pract. 1995;28:137-146.
26. Azab B,Zaher M,Weiserbs KF, et al.Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction.Am J Cardiol. 2010;106:470-476.
27. Papa A,Emdin M,Passino C, et al.Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease.Clin Chim Acta. 2008;395:27-31.
28. Xu Y,Zhao Z,Li X, et al.Relationships between C-reactive protein, white blood cell count, and insulin resistance in a Chinese population.Endocrine. 2011;39:175-181.
29. Rodríguez-Morán M,Guerrero-Romero F.Increased levels of C-reactive protein in noncontrolled type II diabetic subjects.J Diabetes Complicat. 1999;13:211-215.
30. Veronelli A,Laneri M,Ranieri R, et al.White blood cells in obesity and diabetes: effects of weight loss and normalization of glucose metabolism.Diabetes Care. 2004;27:2501-2502.
31. Çoban E,Sari{dotless} R.The Levels of Serum High Sensitivity C-reactive Protein in Subjects with Impaired Fasting Glucose.Turkish Journal of Endocrinology and Metabolism. 2003;4:165-168.