Metabolic network analysis-based identification of antimicrobial drug targets in Category A bioterrorism agents

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Ahn, Yong Yeol ^a   Lee, Deok Sun ^b   Burd, Henry ^c   Blank, William ^c   Kapatral, Vinayak ^c  

^a INDIANA UNIVERSITY   (United States)

^b Inha University   (South Korea)

^c Igenbio Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; COENZYME A; FOLIC ACID; NUCLEIC ACID; PHOSPHATIDYLETHANOLAMINE;

ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL STRAIN; BIOLOGICAL WARFARE; CLINICAL PROTOCOL; DRUG TARGETING; FRANCISELLA TULARENSIS; HUMAN; NONHUMAN; SPECIES DIFFERENCE; YERSINIA PESTIS; DRUG EFFECTS; PATHOGENICITY;

ANTI-INFECTIVE AGENTS; BACILLUS ANTHRACIS; BIOTERRORISM; FRANCISELLA TULARENSIS; YERSINIA PESTIS;

EID: 84898669706     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085195     Document Type: Article

References (33)

1. Pohanka M, Skladal P (2009) Bacillus anthracis, Francisella tularensis and Yersinia pestis. The most important bacterial warfare agents 54:263-272.
2. Gilligan PH (2002) Therapeutic challenges posed by bacterial bioterrorism threats. Curr Opin Microbiol 5:489-495.
3. Shen Y, Liu J, Estiu G, Isin B, Ahn YY, et al. (2010) A blueprint for antimicrobial hit discovery targeting metabolic networks. Proc Natl Acad Sci USA 107:1082-1087.
4. Pilo P, Frey J (2011) Bacillus anthracis: Molecular taxonomy, population genetics, phylogeny and patho-evolution. Infect Gen Evol 11:1218-1224.
5. Oyston PC, Sjostedt A, Titball RW (2004) Tularaemia: bioterrorism defence (Pubitemid 39562535)
6. Titball RW, Petrosino JF (2007) Francisella tularensis genomics and proteomics. Ann. N Y Acad Sci 1105:98-121. (Pubitemid 47507096)
7. Pechous RD, McCarthy TR, Zahrt TC (2009) Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development. Microbiol Mol Biol Rev 73:684-711.
8. Johansson A, Goransson I, Larsson P, Sjostedt A (2001) Extensive allelic variation among Francisella tularensis strains in a short-sequence tandem repeat region. J Clin Microbiol 39:3140-3146. (Pubitemid 32830306)
9. Chaudhuri R R, Ren CP, Desmond L, Vincent GA, Silman NJ, et al. (2007) Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4. PLoS One 2:e352.
10. Achtman M, Morelli G, Zhu P, Wirth T, Diehl I, et al. (2004) Microevolution and history of the plague bacillus, Yersinia pestis. Proc Natl Acad Sci 51:17837-42. (Pubitemid 40051973)
11. Champion MD, Zeng Q, Nix E. B, Nano FE, Keim P, et al. (2009) Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies. PLoS Pathog 5(5):e1000459.
12. Gallagher LA, Ramage E, Jacobs MA, Kaul R, Brittnacher M, et al. (2007) A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogate. Proc Natl Acad Sci USA 104:1009-1014. (Pubitemid 46154727)
13. Kraemer PS, Mitchell A, Pelletier MR, Gallagher LA, Wasnick M, et al. (2009) Genome-wide screen in Francisella novicida for genes required for pulmonary and systemic infection in mice. Infect Immun 77:232-244.
14. Charusanti P, Chauhan S, McAteer K, Lerman JA, Hyduke DR, et al. (2011) An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92. BMC Syst Biol 5:163.
15. Edwards JS, Palsson BO (2000) The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities. Proc Natl Acad Sci USA 97:5528-5533. (Pubitemid 30313752)
16. Almaas E, Kovacs B, Vicsek T, Oltvai ZN, Barabasi AL (2004) Global organization of metabolic fluxes in the bacterium Escherichia coli. Nature 427:839-843. (Pubitemid 38297745)
17. Almaas E, Oltvai ZN, Barabasi AL (2005) The activity reaction core and plasticity of metabolic networks. PLoS Comput Biol 1:e68.
18. Joyce AR, Palsson BO (2008) Predicting gene essentiality using genome-scale in silico models. Methods Mol Biol 416:433-457.
19. Lee DS, Burd H, Liu J, Almaas E, Wiest O, et al. (2009) Comparative genomescale metabolic reconstruction and flux balance analysis of multiple Staphylococcus aureus genomes identify novel antimicrobial drug targets. J Bacteriol 191:4015-4024.
20. Boyle DS, Donachie WD (1998) mraY is an essential gene for cell growth in Escherichia coli. J Bacteriol 180:6429-6432. (Pubitemid 28544283)
21. González-Pastor JE, Hobbs EC, Losick R (2003) Cannibalism by sporulating bacteria. Science 301:510-513. (Pubitemid 36900307)
22. Wei Y, Newman EB (2000) Studies on the role of the metK gene product of Escherichia coli K-12. Mol Microbiol 43:1651-1656.
23. Sorci L, Martynowski D, Rodionov DA, Eyobo Y, Zogaj X., et al. (2009) Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. Proc Natl Acad Sci USA 106:3083-3088.
24. Zhang R, Lin Y (2009) DEG 5.0 a database of essential genes in both prokaryotes and eukaryotes. Nuc Acid Res 37:455-458.
25. Chaperon DN (2006) Construction and complementation of in frame deletions of the essential Escherichia coli thymidylate kinase gene. Appl Envir. Microbiol 72:1288-1294.
26. Hare RS, Walker SS, Dorman TE, Greene JR, Guzman, et al. (2001) Genetic footprinting in bacteria. J Bacteriol 183, 1694-1706. (Pubitemid 32172313)
27. Mathieu M, Debousker G, Vincent S, Viviani F, Bamas-Jacques N, et al. (2005) Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy. J Biol Chem 280:18916-22. (Pubitemid 41379594)
28. Kwon YK, Lu W, Melamud E, Khanam N, Bognar A, et al. (2008) A domino effect in antifolate drug action in Escherichia coli. Nat Chem Biol 4:602-8.
29. Wong JD, Barash JR, Sandfort RF, Janda JM (2000) Susceptibilities of Yersinia pestis strains to 12 antimicrobial agents. Antimicrob Agents Chemother 44:1995-6. (Pubitemid 30422964)
30. Barrow EW, Dreier J, Reinelt S, Bourne PC, Barrow WW (2007) In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis. Antimicrob Agents Chemother 51:4447-52. (Pubitemid 350209901)
31. Bourne CR, Barrow EW, Bunce RA, Bourne PC, Berlin KD, et al. (2010) Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. Antimicrob Agents Chemother 54:3825-33.
32. Overbeek R, Larsen N, Walunas T, D'Souza M, Pusch G, et al. (2003) The ERGO genome analysis and discovery system. Nucleic Acids Res 31:164-171. (Pubitemid 36150356)
33. Kobayashi K, Ehrlich SD, Albertini A, Amati G, Andersen KK, et al. (2003) Essential Bacillus subtilis genes. Proc Natl Acad Sci 100:4678-83. (Pubitemid 36457789)