Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Rao, Raghavendra Pralhada ^a   Scheffer, Luana ^a   Srideshikan, Sargur M ^a   Parthibane, Velayoudame ^a   Kosakowska Cholody, Teresa ^a   Masood, M Athar ^b   Nagashima, Kunio ^b   Gudla, Prabhakar ^b   Lockett, Stephen ^b   Acharya, Usha ^c   Acharya, Jairaj K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CERAMIDE; CERAMIDE HEXOSIDE; CERAMIDE TRANSFER PROTEIN; GLUTATHIONE REDUCTASE; REACTIVE OXYGEN METABOLITE; SPHINGOLIPID; UNCLASSIFIED DRUG; CHOLERA TOXIN; COL4A3BP PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; CELL AGING; CELL FUNCTION; CELL MEMBRANE; CELL ORGANELLE; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FIBROBLAST; GOLGI COMPLEX; INTRACELLULAR TRANSPORT; LIPID METABOLISM; LIPID TRANSPORT; MITOCHONDRIAL DYNAMICS; MITOPHAGY; MOUSE; NONHUMAN; PROTEIN FUNCTION; ANIMAL; ANIMAL EMBRYO; CELL PROLIFERATION; CELL SURVIVAL; DEFICIENCY; FEMALE; GENE EXPRESSION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; PRIMARY CELL CULTURE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CERAMIDES; CHOLERA TOXIN; EMBRYO, MAMMALIAN; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; FIBROBLASTS; GENE EXPRESSION; GOLGI APPARATUS; LIPID METABOLISM; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; PRIMARY CELL CULTURE; PROTEIN-SERINE-THREONINE KINASES;

EID: 84898657224     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092142     Document Type: Article

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