The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells

Carcinogenesis

Volumn 35, Issue 4, 2014, Pages 942-950

  Hütz, Katharina ^a,b   Mejías luque, Raquel ^a   Farsakova, Katarina ^b   Ogris, Manfred ^b   Krebs, Stefan ^b   Anton, Martina ^c   Vieth, Michael ^d   Schüller, Ulrich ^b   Schneider, Marlon R ^b   Blum, Helmut ^b   Wagner, Ernst ^b   Jung, Andreas ^b   Gerhard, Markus ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d INSTITUTE OF PATHOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR SOX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN AZ 521; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STOMACH CARCINOGENESIS; STOMACH CARCINOMA;

ANIMALS; BASE SEQUENCE; CARCINOGENESIS; CELL LINE, TUMOR; DNA PRIMERS; FEMALE; HUMANS; MICE; REAL-TIME POLYMERASE CHAIN REACTION; SOXB1 TRANSCRIPTION FACTORS; STOMACH NEOPLASMS;

EID: 84898651790     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt410     Document Type: Article

References (50)

1. Parkin, D.M. et al. (2005) Global cancer statistics, 2002. CA. Cancer J. Clin., 55, 74-108.
2. Tahara, E. (2004) Genetic pathways of two types of gastric cancer. IARC Sci. Publ., 327-349.
3. Arnold, K. et al. (2011) Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell, 9, 317-329.
4. Wegner, M. (1999) From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res., 27, 1409-1420.
5. Boyer, L.A. et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell, 122, 947-956.
6. Takahashi, K. et al. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663-676.
7. Sattler, H.P. et al. (2000) Novel amplification unit at chromosome 3q25-q27 in human prostate cancer. Prostate, 45, 207-215.
8. Sanada, Y. et al. (2006) Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intraductal components. Pancreas, 32, 164-170.
9. Rodriguez-Pinilla, S.M. et al. (2007) Sox2: a possible driver of the basallike phenotype in sporadic breast cancer. Mod. Pathol., 20, 474-481.
10. Gangemi, R.M. et al. (2009) SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells, 27, 40-48.
11. Neumann, J. et al. (2011) SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer. BMC Cancer, 11, 518.
12. Lin, F. et al. (2012) Sox2 targets cyclinE, p27 and survivin to regulate androgen-independent human prostate cancer cell proliferation and apoptosis. Cell Prolif., 45, 207-216.
13. Rybak, A.P. et al. (2013) SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells. Cell. Signal., 25, 2734-2742.
14. Hussenet, T. et al. (2010) SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS One, 5, e8960.
15. Bass, A.J. et al. (2009) SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat. Genet., 41, 1238-1242.
16. Otsubo, T. et al. (2008) SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br. J. Cancer, 98, 824-831.
17. Tian, T. et al. (2012) Sox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancer. J. Biomed. Res., 26, 336-345.
18. Hojo, H. et al. (1977) Case suspected to be atypical diffuse myeloma. Nihon Rinsho., 35, 2659-2662.
19. Akiyama, S. et al. (1988) Characteristics of three human gastric cancer cell lines, NU-GC-2, NU-GC-3 and NU-GC-4. Jpn. J. Surg., 18, 438-446.
20. Vollmers, H.P. et al. (1993) Characterization of four new gastric cancer cell lines. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol., 63, 335-343.
21. van de Wetering, M. et al. (1997) Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell, 88, 789-99.
22. Wettenhall, J.M. et al. (2004) limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics, 20, 3705-3706.
23. Wübbenhorst, D. et al. (2010) Tetracycline-regulated bone morphogenetic protein 2 gene expression in lentivirally transduced primary rabbit chondrocytes for treatment of cartilage defects. Arthritis Rheum., 62, 2037-2046.
24. Li, X.L. et al. (2004) Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int. J. Oncol., 24, 257-263.
25. Smyth, G.K. (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol., 3, Article 3.
26. Macarthur, B.D. et al. (2009) Systems biology of stem cell fate and cellular reprogramming. Nat. Rev. Mol. Cell Biol., 10, 672-681.
27. Nyeng, P. et al. (2007) FGF10 signaling controls stomach morphogenesis. Dev. Biol., 303, 295-310.
28. Kormish, J.D. et al. (2010) Interactions between SOX factors and Wnt/betacatenin signaling in development and disease. Dev. Dyn., 239, 56-68.
29. Park, S.B. et al. (2012) SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC. Cell Death Differ., 19, 534-545.
30. Mansukhani, A. et al. (2005) Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J. Cell Biol., 168, 1065-1076.
31. Otsubo, T. et al. (2011) MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS One, 6, e16617.
32. Zhang, X. et al. (2010) SOX2 in gastric carcinoma, but not Hath1, is related to patients' clinicopathological features and prognosis. J. Gastrointest. Surg., 14, 1220-1226.
33. Matsuoka, J. et al. (2012) Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma. J. Surg. Res., 174, 130-135.
34. Tsuruzoe, S. et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem. Biophys. Res. Commun., 351, 920-926.
35. Jeong, C.H. et al. (2010) Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells. Stem Cells, 28, 2141-2150.
36. Baltus, G.A. et al. (2009) Acetylation of sox2 induces its nuclear export in embryonic stem cells. Stem Cells, 27, 2175-2184.
37. Chen, Y. et al. (2008) The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J. Biol. Chem., 283, 17969-17978.
38. Xiang, R. et al. (2011) Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br. J. Cancer, 104, 1410-1417.
39. Oppel, F. et al. (2011) SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells. Mol. Cancer, 10, 137.
40. Abbas, T. et al. (2009) p21 in cancer: intricate networks and multiple activities. Nat. Rev. Cancer, 9, 400-414.
41. Seo, Y.H. et al. (2003) Prognostic significance of p21 and p53 expression in gastric cancer. Korean J. Intern. Med., 18, 98-103.
42. Kouraklis, G. et al. (2009) Does the expression of cyclin E, pRb, and p21 correlate with prognosis in gastric adenocarcinoma? Dig. Dis. Sci., 54, 1015-1020.
43. Long, K.B. et al. (2009) SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract. Hum. Pathol., 40, 1768-1773.
44. Hussenet, T. et al. (2010) SOX2 in squamous cell carcinoma: amplifying a pleiotropic oncogene along carcinogenesis. Cell Cycle, 9, 1480-1486.
45. Wang, H. et al. (2012) ΔNp63α mediates proliferation and apoptosis in human gastric cancer cells by the regulation of GATA-6. Neoplasma, 59, 416-423.
46. Bazzi, H. et al. (2007) The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis. Dev. Biol., 305, 498-507.
47. Fatima, S. et al. (2012) Dickkopf 4 (DKK4) acts on Wnt/ß-catenin pathway by influencing ß-catenin in hepatocellular carcinoma. Oncogene, 31, 4233-4244.
48. Que, J. et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development, 134, 2521-2531.
49. Dean, C.H. et al. (2005) Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland. Dev. Biol., 286, 270-286.
50. Cox, J.L. et al. (2010) Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes. PLoS One, 5, e15486.